The Value of Serum Adiponectin in Osteoporotic Women: Does Weight Have an Effect?

Osteoporosis (OP) has been observed to have a deleterious effect on postmenopausal women’s life quality by increasing the risk of fragility fractures. The current research was adopted to verify the role of serum adiponectin, a cytokine released by adipose tissue, as a marker for OP across different...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ali B. Roomi, Wassan Nori, Saad H. Al-Badry
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/132e5726d0de4d9180843b1199f959b5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:132e5726d0de4d9180843b1199f959b5
record_format	dspace
spelling	oai:doaj.org-article:132e5726d0de4d9180843b1199f959b52021-11-22T01:11:23ZThe Value of Serum Adiponectin in Osteoporotic Women: Does Weight Have an Effect?2090-071610.1155/2021/5325813https://doaj.org/article/132e5726d0de4d9180843b1199f959b52021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5325813https://doaj.org/toc/2090-0716Osteoporosis (OP) has been observed to have a deleterious effect on postmenopausal women’s life quality by increasing the risk of fragility fractures. The current research was adopted to verify the role of serum adiponectin, a cytokine released by adipose tissue, as a marker for OP across different body mass index groups, for a better understanding of fatty tissue role in OP. A case-control study recruited 210 eligible postmenopausal women and subgrouped into three groups based on their DEXA scan results: osteoporotic group, osteopenia group, and healthy controls; each includes 70 patients. Three datasets were collected: anthropometric, age, menopause duration, weight, height, body mass index (BMI), waist circumference, and fat percentage. Radiological examination estimated the bone mineral density (BMD) for the femoral neck and lumbar spines with their respective T-score. From blood, we measured alkaline phosphatase and calcium by a spectrophotometer and serum adiponectin, phosphate, CTX, and PICP by ELIZA. Total BMD, T-score, serum phosphate, and PICP were significantly higher among healthy controls. Serum adiponectin, CTX, and ALP scored higher levels among OP cases. A strong inverse relationship was proved between serum adiponectin and T-score in osteoporotic and osteopenia groups (−0.427, −0.301). A strong negative relationship was found between serum adiponectin and total BMD in healthy controls (−0.204). All correlations were statistically significant, P value <0.001. Serum adiponectin can be a valuable marker for reduced bone mineral density among the general populace, irrespective of the body mass index. Further research is warranted to explore therapeutic and preventive applications for this adipocytokine.Ali B. RoomiWassan NoriSaad H. Al-BadryHindawi LimitedarticleInternal medicineRC31-1245ENJournal of Obesity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Internal medicine RC31-1245
spellingShingle	Internal medicine RC31-1245 Ali B. Roomi Wassan Nori Saad H. Al-Badry The Value of Serum Adiponectin in Osteoporotic Women: Does Weight Have an Effect?
description	Osteoporosis (OP) has been observed to have a deleterious effect on postmenopausal women’s life quality by increasing the risk of fragility fractures. The current research was adopted to verify the role of serum adiponectin, a cytokine released by adipose tissue, as a marker for OP across different body mass index groups, for a better understanding of fatty tissue role in OP. A case-control study recruited 210 eligible postmenopausal women and subgrouped into three groups based on their DEXA scan results: osteoporotic group, osteopenia group, and healthy controls; each includes 70 patients. Three datasets were collected: anthropometric, age, menopause duration, weight, height, body mass index (BMI), waist circumference, and fat percentage. Radiological examination estimated the bone mineral density (BMD) for the femoral neck and lumbar spines with their respective T-score. From blood, we measured alkaline phosphatase and calcium by a spectrophotometer and serum adiponectin, phosphate, CTX, and PICP by ELIZA. Total BMD, T-score, serum phosphate, and PICP were significantly higher among healthy controls. Serum adiponectin, CTX, and ALP scored higher levels among OP cases. A strong inverse relationship was proved between serum adiponectin and T-score in osteoporotic and osteopenia groups (−0.427, −0.301). A strong negative relationship was found between serum adiponectin and total BMD in healthy controls (−0.204). All correlations were statistically significant, P value <0.001. Serum adiponectin can be a valuable marker for reduced bone mineral density among the general populace, irrespective of the body mass index. Further research is warranted to explore therapeutic and preventive applications for this adipocytokine.
format	article
author	Ali B. Roomi Wassan Nori Saad H. Al-Badry
author_facet	Ali B. Roomi Wassan Nori Saad H. Al-Badry
author_sort	Ali B. Roomi
title	The Value of Serum Adiponectin in Osteoporotic Women: Does Weight Have an Effect?
title_short	The Value of Serum Adiponectin in Osteoporotic Women: Does Weight Have an Effect?
title_full	The Value of Serum Adiponectin in Osteoporotic Women: Does Weight Have an Effect?
title_fullStr	The Value of Serum Adiponectin in Osteoporotic Women: Does Weight Have an Effect?
title_full_unstemmed	The Value of Serum Adiponectin in Osteoporotic Women: Does Weight Have an Effect?
title_sort	value of serum adiponectin in osteoporotic women: does weight have an effect?
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/132e5726d0de4d9180843b1199f959b5
work_keys_str_mv	AT alibroomi thevalueofserumadiponectininosteoporoticwomendoesweighthaveaneffect AT wassannori thevalueofserumadiponectininosteoporoticwomendoesweighthaveaneffect AT saadhalbadry thevalueofserumadiponectininosteoporoticwomendoesweighthaveaneffect AT alibroomi valueofserumadiponectininosteoporoticwomendoesweighthaveaneffect AT wassannori valueofserumadiponectininosteoporoticwomendoesweighthaveaneffect AT saadhalbadry valueofserumadiponectininosteoporoticwomendoesweighthaveaneffect
_version_	1718418264249335808

The Value of Serum Adiponectin in Osteoporotic Women: Does Weight Have an Effect?

Ejemplares similares