Renal artery denervation in patients with resistant arterial hypertension: clinical and organ-protective effect

Aim. To assess the clinical efficacy of renal artery denervation (RAD) in treatment of patients with resistant arterial hypertension (RAH) compared to patients taking drug therapy (DT) at long-term follow-up and the possibility of RAD impact on target organs (heart, kidneys). Materials and method...

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Autores principales:	Liudmila I. Gapon, Ekaterina V. Mikova, Dmitrij V. Krinochkin, Nina Yu. Savelyeva, Anna Yu. Zherzhova, Ekaterina L. Aleksandrovich
Formato:	article
Lenguaje:	RU
Publicado:	IP Morozov P.V. 2021
Materias:	resistant arterial hypertension renal artery denervation target organs Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/132e657de3ed4dbc8f73e48846a43278
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spelling	oai:doaj.org-article:132e657de3ed4dbc8f73e48846a432782021-11-30T16:09:16ZRenal artery denervation in patients with resistant arterial hypertension: clinical and organ-protective effect2075-082X2542-218910.26442/2075082X.2021.3.201090https://doaj.org/article/132e657de3ed4dbc8f73e48846a432782021-10-01T00:00:00Zhttps://syst-hypertension.ru/2075-082X/article/viewFile/46835/pdfhttps://doaj.org/toc/2075-082Xhttps://doaj.org/toc/2542-2189Aim. To assess the clinical efficacy of renal artery denervation (RAD) in treatment of patients with resistant arterial hypertension (RAH) compared to patients taking drug therapy (DT) at long-term follow-up and the possibility of RAD impact on target organs (heart, kidneys). Materials and methods. 80 RAH patients were examined (mean age 54.3010.19 years). Patients were divided in two groups: the basic group was comprised of 40 RAH patients taking antihypertensive DT, who underwent RAD (gr. 1) and comparison group was composed of 40 RAH patients taking only antihypertensive DT (gr. 2). Gender and age differences between groups were statistically insignificant (p0.05). Mean duration of AH was 18.638.96 years. The follow-up was carried out during one year. Results. In RAD group there was confirmed decrease not only in the office, but also in the average day-time and night-time blood pressure (BP), changes were more significant in systolic BP (SBP) indicators: the overall daytime SBP was 17.369.31 mmHg (p0.001), the average day-time SBP was 17.1810.53 mmHg (p0.001), the average night-time SBP was 19.2210.76 mmHg (p0.001). At the same time, in DT group changes in values of overall, maximum, minimum, average day-time and average night-time SBP and diastolic BP were not statistically significant in 12 months. RAD in RAH was accompanied by decrease in left ventricular hypertrophy with initial hypertrophy (p0.05), decrease in microalbuminuria (p0.05), decrease in velocity in segmental (p0.05) and interlobar renal arteries (p0.01). Conclusion. RAD in patients with RAH had not only antihypertensive effect but also positive effect on target organs of AH (heart, kidneys).Liudmila I. GaponEkaterina V. MikovaDmitrij V. KrinochkinNina Yu. SavelyevaAnna Yu. ZherzhovaEkaterina L. AleksandrovichIP Morozov P.V.articleresistant arterial hypertensionrenal artery denervationtarget organsDiseases of the circulatory (Cardiovascular) systemRC666-701RUСистемные гипертензии, Vol 18, Iss 3, Pp 153-160 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	resistant arterial hypertension renal artery denervation target organs Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	resistant arterial hypertension renal artery denervation target organs Diseases of the circulatory (Cardiovascular) system RC666-701 Liudmila I. Gapon Ekaterina V. Mikova Dmitrij V. Krinochkin Nina Yu. Savelyeva Anna Yu. Zherzhova Ekaterina L. Aleksandrovich Renal artery denervation in patients with resistant arterial hypertension: clinical and organ-protective effect
description	Aim. To assess the clinical efficacy of renal artery denervation (RAD) in treatment of patients with resistant arterial hypertension (RAH) compared to patients taking drug therapy (DT) at long-term follow-up and the possibility of RAD impact on target organs (heart, kidneys). Materials and methods. 80 RAH patients were examined (mean age 54.3010.19 years). Patients were divided in two groups: the basic group was comprised of 40 RAH patients taking antihypertensive DT, who underwent RAD (gr. 1) and comparison group was composed of 40 RAH patients taking only antihypertensive DT (gr. 2). Gender and age differences between groups were statistically insignificant (p0.05). Mean duration of AH was 18.638.96 years. The follow-up was carried out during one year. Results. In RAD group there was confirmed decrease not only in the office, but also in the average day-time and night-time blood pressure (BP), changes were more significant in systolic BP (SBP) indicators: the overall daytime SBP was 17.369.31 mmHg (p0.001), the average day-time SBP was 17.1810.53 mmHg (p0.001), the average night-time SBP was 19.2210.76 mmHg (p0.001). At the same time, in DT group changes in values of overall, maximum, minimum, average day-time and average night-time SBP and diastolic BP were not statistically significant in 12 months. RAD in RAH was accompanied by decrease in left ventricular hypertrophy with initial hypertrophy (p0.05), decrease in microalbuminuria (p0.05), decrease in velocity in segmental (p0.05) and interlobar renal arteries (p0.01). Conclusion. RAD in patients with RAH had not only antihypertensive effect but also positive effect on target organs of AH (heart, kidneys).
format	article
author	Liudmila I. Gapon Ekaterina V. Mikova Dmitrij V. Krinochkin Nina Yu. Savelyeva Anna Yu. Zherzhova Ekaterina L. Aleksandrovich
author_facet	Liudmila I. Gapon Ekaterina V. Mikova Dmitrij V. Krinochkin Nina Yu. Savelyeva Anna Yu. Zherzhova Ekaterina L. Aleksandrovich
author_sort	Liudmila I. Gapon
title	Renal artery denervation in patients with resistant arterial hypertension: clinical and organ-protective effect
title_short	Renal artery denervation in patients with resistant arterial hypertension: clinical and organ-protective effect
title_full	Renal artery denervation in patients with resistant arterial hypertension: clinical and organ-protective effect
title_fullStr	Renal artery denervation in patients with resistant arterial hypertension: clinical and organ-protective effect
title_full_unstemmed	Renal artery denervation in patients with resistant arterial hypertension: clinical and organ-protective effect
title_sort	renal artery denervation in patients with resistant arterial hypertension: clinical and organ-protective effect
publisher	IP Morozov P.V.
publishDate	2021
url	https://doaj.org/article/132e657de3ed4dbc8f73e48846a43278
work_keys_str_mv	AT liudmilaigapon renalarterydenervationinpatientswithresistantarterialhypertensionclinicalandorganprotectiveeffect AT ekaterinavmikova renalarterydenervationinpatientswithresistantarterialhypertensionclinicalandorganprotectiveeffect AT dmitrijvkrinochkin renalarterydenervationinpatientswithresistantarterialhypertensionclinicalandorganprotectiveeffect AT ninayusavelyeva renalarterydenervationinpatientswithresistantarterialhypertensionclinicalandorganprotectiveeffect AT annayuzherzhova renalarterydenervationinpatientswithresistantarterialhypertensionclinicalandorganprotectiveeffect AT ekaterinalaleksandrovich renalarterydenervationinpatientswithresistantarterialhypertensionclinicalandorganprotectiveeffect
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Renal artery denervation in patients with resistant arterial hypertension: clinical and organ-protective effect

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