Does Exposure to General Anesthesia Increase Risk of ADHD for Children Before Age of Three?

Objective: The objective of the study was to evaluate the relationship between frequency of exposure to general anesthesia before the age of 3 and subsequent risk of diagnosis for attention-deficit hyperactivity disorder (ADHD).Method: We searched PubMed, Embase, Web of Science, and Cochrane Library...

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Autores principales:	Junjie Song, Huifang Li, Ying Wang, Chenguang Niu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	general anesthesia ADHD children meta-analysis single multiple Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/132f87d06ad84c4890472b1a680226d3
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spelling	oai:doaj.org-article:132f87d06ad84c4890472b1a680226d32021-11-30T19:17:38ZDoes Exposure to General Anesthesia Increase Risk of ADHD for Children Before Age of Three?1664-064010.3389/fpsyt.2021.717093https://doaj.org/article/132f87d06ad84c4890472b1a680226d32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.717093/fullhttps://doaj.org/toc/1664-0640Objective: The objective of the study was to evaluate the relationship between frequency of exposure to general anesthesia before the age of 3 and subsequent risk of diagnosis for attention-deficit hyperactivity disorder (ADHD).Method: We searched PubMed, Embase, Web of Science, and Cochrane Library database for eligible inclusion in the meta-analysis. The indicated outcomes were extracted from the included studies, and the combined effects were calculated using the RevMan software 5.3.Results: Compared with no exposure to general anesthesia, single exposure to general anesthesia did not increase the risk of ADHD for children before the age of 3 [hazard ratio (HR): 1.14, 95%; confidence intervals (CI): 0.97–1.35; p = 0.11; I2 = 0%], while multiple exposures to general anesthesia did increase the risk of ADHD (HR: 1.83; 95% CIs: 1.00–3.32; p = 0.05; I2 = 81%).Conclusion: Multiple, but not single, exposures to general anesthesia in children before age of 3 increased the risk of ADHD.Junjie SongHuifang LiYing WangChenguang NiuChenguang NiuFrontiers Media S.A.articlegeneral anesthesiaADHDchildrenmeta-analysissinglemultiplePsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	general anesthesia ADHD children meta-analysis single multiple Psychiatry RC435-571
spellingShingle	general anesthesia ADHD children meta-analysis single multiple Psychiatry RC435-571 Junjie Song Huifang Li Ying Wang Chenguang Niu Chenguang Niu Does Exposure to General Anesthesia Increase Risk of ADHD for Children Before Age of Three?
description	Objective: The objective of the study was to evaluate the relationship between frequency of exposure to general anesthesia before the age of 3 and subsequent risk of diagnosis for attention-deficit hyperactivity disorder (ADHD).Method: We searched PubMed, Embase, Web of Science, and Cochrane Library database for eligible inclusion in the meta-analysis. The indicated outcomes were extracted from the included studies, and the combined effects were calculated using the RevMan software 5.3.Results: Compared with no exposure to general anesthesia, single exposure to general anesthesia did not increase the risk of ADHD for children before the age of 3 [hazard ratio (HR): 1.14, 95%; confidence intervals (CI): 0.97–1.35; p = 0.11; I2 = 0%], while multiple exposures to general anesthesia did increase the risk of ADHD (HR: 1.83; 95% CIs: 1.00–3.32; p = 0.05; I2 = 81%).Conclusion: Multiple, but not single, exposures to general anesthesia in children before age of 3 increased the risk of ADHD.
format	article
author	Junjie Song Huifang Li Ying Wang Chenguang Niu Chenguang Niu
author_facet	Junjie Song Huifang Li Ying Wang Chenguang Niu Chenguang Niu
author_sort	Junjie Song
title	Does Exposure to General Anesthesia Increase Risk of ADHD for Children Before Age of Three?
title_short	Does Exposure to General Anesthesia Increase Risk of ADHD for Children Before Age of Three?
title_full	Does Exposure to General Anesthesia Increase Risk of ADHD for Children Before Age of Three?
title_fullStr	Does Exposure to General Anesthesia Increase Risk of ADHD for Children Before Age of Three?
title_full_unstemmed	Does Exposure to General Anesthesia Increase Risk of ADHD for Children Before Age of Three?
title_sort	does exposure to general anesthesia increase risk of adhd for children before age of three?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/132f87d06ad84c4890472b1a680226d3
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Does Exposure to General Anesthesia Increase Risk of ADHD for Children Before Age of Three?

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