Gut microbiota composition in health-care facility-and community-onset diarrheic patients with Clostridioides difficile infection

Abstract The role of gut microbiota in the establishment and development of Clostridioides difficile infection (CDI) has been widely discussed. Studies showed the impact of CDI on bacterial communities and the importance of some genera and species in recovering from and preventing infection. However...

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Autores principales:	Giovanny Herrera, Laura Vega, Manuel Alfonso Patarroyo, Juan David Ramírez, Marina Muñoz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13306252d1f544139e6f74bd0bf48dfd
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spelling	oai:doaj.org-article:13306252d1f544139e6f74bd0bf48dfd2021-12-02T14:49:17ZGut microbiota composition in health-care facility-and community-onset diarrheic patients with Clostridioides difficile infection10.1038/s41598-021-90380-72045-2322https://doaj.org/article/13306252d1f544139e6f74bd0bf48dfd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90380-7https://doaj.org/toc/2045-2322Abstract The role of gut microbiota in the establishment and development of Clostridioides difficile infection (CDI) has been widely discussed. Studies showed the impact of CDI on bacterial communities and the importance of some genera and species in recovering from and preventing infection. However, most studies have overlooked important components of the intestinal ecosystem, such as eukaryotes and archaea. We investigated the bacterial, archaea, and eukaryotic intestinal microbiota of patients with health-care-facility- or community-onset (HCFO and CO, respectively) diarrhea who were positive or negative for CDI. The CDI-positive groups (CO/+, HCFO/+) showed an increase in microorganisms belonging to Bacteroidetes, Firmicutes, Proteobacteria, Ascomycota, and Opalinata compared with the CDI-negative groups (CO/−, HCFO/−). Patients with intrahospital-acquired diarrhea (HCFO/+, HCFO/−) showed a marked decrease in bacteria beneficial to the intestine, and there was evidence of increased Archaea and Candida and Malassezia species compared with the CO groups (CO/+, CO/−). Characteristic microbiota biomarkers were established for each group. Finally, correlations between bacteria and eukaryotes indicated interactions among the different kingdoms making up the intestinal ecosystem. We showed the impact of CDI on microbiota and how it varies with where the infection is acquired, being intrahospital-acquired diarrhea one of the most influential factors in the modulation of bacterial, archaea, and eukaryotic populations. We also highlight interactions between the different kingdoms of the intestinal ecosystem, which need to be evaluated to improve our understanding of CDI pathophysiology.Giovanny HerreraLaura VegaManuel Alfonso PatarroyoJuan David RamírezMarina MuñozNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giovanny Herrera Laura Vega Manuel Alfonso Patarroyo Juan David Ramírez Marina Muñoz Gut microbiota composition in health-care facility-and community-onset diarrheic patients with Clostridioides difficile infection
description	Abstract The role of gut microbiota in the establishment and development of Clostridioides difficile infection (CDI) has been widely discussed. Studies showed the impact of CDI on bacterial communities and the importance of some genera and species in recovering from and preventing infection. However, most studies have overlooked important components of the intestinal ecosystem, such as eukaryotes and archaea. We investigated the bacterial, archaea, and eukaryotic intestinal microbiota of patients with health-care-facility- or community-onset (HCFO and CO, respectively) diarrhea who were positive or negative for CDI. The CDI-positive groups (CO/+, HCFO/+) showed an increase in microorganisms belonging to Bacteroidetes, Firmicutes, Proteobacteria, Ascomycota, and Opalinata compared with the CDI-negative groups (CO/−, HCFO/−). Patients with intrahospital-acquired diarrhea (HCFO/+, HCFO/−) showed a marked decrease in bacteria beneficial to the intestine, and there was evidence of increased Archaea and Candida and Malassezia species compared with the CO groups (CO/+, CO/−). Characteristic microbiota biomarkers were established for each group. Finally, correlations between bacteria and eukaryotes indicated interactions among the different kingdoms making up the intestinal ecosystem. We showed the impact of CDI on microbiota and how it varies with where the infection is acquired, being intrahospital-acquired diarrhea one of the most influential factors in the modulation of bacterial, archaea, and eukaryotic populations. We also highlight interactions between the different kingdoms of the intestinal ecosystem, which need to be evaluated to improve our understanding of CDI pathophysiology.
format	article
author	Giovanny Herrera Laura Vega Manuel Alfonso Patarroyo Juan David Ramírez Marina Muñoz
author_facet	Giovanny Herrera Laura Vega Manuel Alfonso Patarroyo Juan David Ramírez Marina Muñoz
author_sort	Giovanny Herrera
title	Gut microbiota composition in health-care facility-and community-onset diarrheic patients with Clostridioides difficile infection
title_short	Gut microbiota composition in health-care facility-and community-onset diarrheic patients with Clostridioides difficile infection
title_full	Gut microbiota composition in health-care facility-and community-onset diarrheic patients with Clostridioides difficile infection
title_fullStr	Gut microbiota composition in health-care facility-and community-onset diarrheic patients with Clostridioides difficile infection
title_full_unstemmed	Gut microbiota composition in health-care facility-and community-onset diarrheic patients with Clostridioides difficile infection
title_sort	gut microbiota composition in health-care facility-and community-onset diarrheic patients with clostridioides difficile infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/13306252d1f544139e6f74bd0bf48dfd
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Gut microbiota composition in health-care facility-and community-onset diarrheic patients with Clostridioides difficile infection

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