Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals.

Glutathione (GSH), a tripeptide antioxidant, is essential for cellular homeostasis and plays a vital role in diverse cellular functions. Individuals who are infected with Human immuno deficiency virus (HIV) are known to be susceptible to Mycobacterium tuberculosis (M. tb) infection. We report that b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Carlos Guerra, Devin Morris, Andrea Sipin, Steven Kung, Mesharee Franklin, Dennis Gray, Michelle Tanzil, Frederick Guilford, Fadi T Khasawneh, Vishwanath Venketaraman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1331e16a2b9f4161984b77e4883675f9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1331e16a2b9f4161984b77e4883675f9
record_format	dspace
spelling	oai:doaj.org-article:1331e16a2b9f4161984b77e4883675f92021-11-18T07:33:07ZGlutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals.1932-620310.1371/journal.pone.0028378https://doaj.org/article/1331e16a2b9f4161984b77e4883675f92011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22164280/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Glutathione (GSH), a tripeptide antioxidant, is essential for cellular homeostasis and plays a vital role in diverse cellular functions. Individuals who are infected with Human immuno deficiency virus (HIV) are known to be susceptible to Mycobacterium tuberculosis (M. tb) infection. We report that by enhancing GSH levels, T-cells are able to inhibit the growth of M. tb inside macrophages. In addition, those GSH-replenished T cell cultures produced increased levels of Interleukin-2 (IL-2), Interleukin-12 (IL-12), and Interferon-gamma (IFN-γ), cytokines, which are known to be crucial for the control of intracellular pathogens. Our study reveals that T lymphocytes that are derived from HIV infected individuals are deficient in GSH, and that this deficiency correlates with decreased levels of Th1 cytokines and enhanced growth of M. tb inside human macrophages.Carlos GuerraDevin MorrisAndrea SipinSteven KungMesharee FranklinDennis GrayMichelle TanzilFrederick GuilfordFadi T KhasawnehVishwanath VenketaramanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e28378 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carlos Guerra Devin Morris Andrea Sipin Steven Kung Mesharee Franklin Dennis Gray Michelle Tanzil Frederick Guilford Fadi T Khasawneh Vishwanath Venketaraman Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals.
description	Glutathione (GSH), a tripeptide antioxidant, is essential for cellular homeostasis and plays a vital role in diverse cellular functions. Individuals who are infected with Human immuno deficiency virus (HIV) are known to be susceptible to Mycobacterium tuberculosis (M. tb) infection. We report that by enhancing GSH levels, T-cells are able to inhibit the growth of M. tb inside macrophages. In addition, those GSH-replenished T cell cultures produced increased levels of Interleukin-2 (IL-2), Interleukin-12 (IL-12), and Interferon-gamma (IFN-γ), cytokines, which are known to be crucial for the control of intracellular pathogens. Our study reveals that T lymphocytes that are derived from HIV infected individuals are deficient in GSH, and that this deficiency correlates with decreased levels of Th1 cytokines and enhanced growth of M. tb inside human macrophages.
format	article
author	Carlos Guerra Devin Morris Andrea Sipin Steven Kung Mesharee Franklin Dennis Gray Michelle Tanzil Frederick Guilford Fadi T Khasawneh Vishwanath Venketaraman
author_facet	Carlos Guerra Devin Morris Andrea Sipin Steven Kung Mesharee Franklin Dennis Gray Michelle Tanzil Frederick Guilford Fadi T Khasawneh Vishwanath Venketaraman
author_sort	Carlos Guerra
title	Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals.
title_short	Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals.
title_full	Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals.
title_fullStr	Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals.
title_full_unstemmed	Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals.
title_sort	glutathione and adaptive immune responses against mycobacterium tuberculosis infection in healthy and hiv infected individuals.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/1331e16a2b9f4161984b77e4883675f9
work_keys_str_mv	AT carlosguerra glutathioneandadaptiveimmuneresponsesagainstmycobacteriumtuberculosisinfectioninhealthyandhivinfectedindividuals AT devinmorris glutathioneandadaptiveimmuneresponsesagainstmycobacteriumtuberculosisinfectioninhealthyandhivinfectedindividuals AT andreasipin glutathioneandadaptiveimmuneresponsesagainstmycobacteriumtuberculosisinfectioninhealthyandhivinfectedindividuals AT stevenkung glutathioneandadaptiveimmuneresponsesagainstmycobacteriumtuberculosisinfectioninhealthyandhivinfectedindividuals AT meshareefranklin glutathioneandadaptiveimmuneresponsesagainstmycobacteriumtuberculosisinfectioninhealthyandhivinfectedindividuals AT dennisgray glutathioneandadaptiveimmuneresponsesagainstmycobacteriumtuberculosisinfectioninhealthyandhivinfectedindividuals AT michelletanzil glutathioneandadaptiveimmuneresponsesagainstmycobacteriumtuberculosisinfectioninhealthyandhivinfectedindividuals AT frederickguilford glutathioneandadaptiveimmuneresponsesagainstmycobacteriumtuberculosisinfectioninhealthyandhivinfectedindividuals AT faditkhasawneh glutathioneandadaptiveimmuneresponsesagainstmycobacteriumtuberculosisinfectioninhealthyandhivinfectedindividuals AT vishwanathvenketaraman glutathioneandadaptiveimmuneresponsesagainstmycobacteriumtuberculosisinfectioninhealthyandhivinfectedindividuals
_version_	1718423269901598720

Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals.

Ejemplares similares