Inhibition of MYC by the SMARCB1 tumor suppressor

SMARCB1/SNF5 is a tumour suppressor and component of the SWI/SNF chromatin remodeler. Here the authors show that, independent of chromatin remodelling activities, SNF5 acts to inhibit the pro-tumorigenic transcriptional program of MYC via control of RNA polymerase pause release at MYC target genes.

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Autores principales:	April M. Weissmiller, Jing Wang, Shelly L. Lorey, Gregory C. Howard, Ernest Martinez, Qi Liu, William P. Tansey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13320eef54514e9293ebfcb6fc8bf6ca
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spelling	oai:doaj.org-article:13320eef54514e9293ebfcb6fc8bf6ca2021-12-02T16:58:25ZInhibition of MYC by the SMARCB1 tumor suppressor10.1038/s41467-019-10022-52041-1723https://doaj.org/article/13320eef54514e9293ebfcb6fc8bf6ca2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10022-5https://doaj.org/toc/2041-1723SMARCB1/SNF5 is a tumour suppressor and component of the SWI/SNF chromatin remodeler. Here the authors show that, independent of chromatin remodelling activities, SNF5 acts to inhibit the pro-tumorigenic transcriptional program of MYC via control of RNA polymerase pause release at MYC target genes.April M. WeissmillerJing WangShelly L. LoreyGregory C. HowardErnest MartinezQi LiuWilliam P. TanseyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q April M. Weissmiller Jing Wang Shelly L. Lorey Gregory C. Howard Ernest Martinez Qi Liu William P. Tansey Inhibition of MYC by the SMARCB1 tumor suppressor
description	SMARCB1/SNF5 is a tumour suppressor and component of the SWI/SNF chromatin remodeler. Here the authors show that, independent of chromatin remodelling activities, SNF5 acts to inhibit the pro-tumorigenic transcriptional program of MYC via control of RNA polymerase pause release at MYC target genes.
format	article
author	April M. Weissmiller Jing Wang Shelly L. Lorey Gregory C. Howard Ernest Martinez Qi Liu William P. Tansey
author_facet	April M. Weissmiller Jing Wang Shelly L. Lorey Gregory C. Howard Ernest Martinez Qi Liu William P. Tansey
author_sort	April M. Weissmiller
title	Inhibition of MYC by the SMARCB1 tumor suppressor
title_short	Inhibition of MYC by the SMARCB1 tumor suppressor
title_full	Inhibition of MYC by the SMARCB1 tumor suppressor
title_fullStr	Inhibition of MYC by the SMARCB1 tumor suppressor
title_full_unstemmed	Inhibition of MYC by the SMARCB1 tumor suppressor
title_sort	inhibition of myc by the smarcb1 tumor suppressor
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/13320eef54514e9293ebfcb6fc8bf6ca
work_keys_str_mv	AT aprilmweissmiller inhibitionofmycbythesmarcb1tumorsuppressor AT jingwang inhibitionofmycbythesmarcb1tumorsuppressor AT shellyllorey inhibitionofmycbythesmarcb1tumorsuppressor AT gregorychoward inhibitionofmycbythesmarcb1tumorsuppressor AT ernestmartinez inhibitionofmycbythesmarcb1tumorsuppressor AT qiliu inhibitionofmycbythesmarcb1tumorsuppressor AT williamptansey inhibitionofmycbythesmarcb1tumorsuppressor
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Inhibition of MYC by the SMARCB1 tumor suppressor

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