Inhibition of MYC by the SMARCB1 tumor suppressor

Inhibition of MYC by the SMARCB1 tumor suppressor

SMARCB1/SNF5 is a tumour suppressor and component of the SWI/SNF chromatin remodeler. Here the authors show that, independent of chromatin remodelling activities, SNF5 acts to inhibit the pro-tumorigenic transcriptional program of MYC via control of RNA polymerase pause release at MYC target genes.

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Autores principales: April M. Weissmiller, Jing Wang, Shelly L. Lorey, Gregory C. Howard, Ernest Martinez, Qi Liu, William P. Tansey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/13320eef54514e9293ebfcb6fc8bf6ca
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