Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures

Understanding of the mycobacterial transcription system is useful to the development of therapeutics against tuberculosis infection. Here the authors present the crystal structure of a completeM. smegmatisRNA polymerase open promoter complex that reveals unique features of the mycobacterial polymera...

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Autores principales: Elizabeth A. Hubin, Mirjana Lilic, Seth A. Darst, Elizabeth A. Campbell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/133287ec42704d49bf169ec537d59a2a
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spelling oai:doaj.org-article:133287ec42704d49bf169ec537d59a2a2021-12-02T14:42:38ZStructural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures10.1038/ncomms160722041-1723https://doaj.org/article/133287ec42704d49bf169ec537d59a2a2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16072https://doaj.org/toc/2041-1723Understanding of the mycobacterial transcription system is useful to the development of therapeutics against tuberculosis infection. Here the authors present the crystal structure of a completeM. smegmatisRNA polymerase open promoter complex that reveals unique features of the mycobacterial polymerase.Elizabeth A. HubinMirjana LilicSeth A. DarstElizabeth A. CampbellNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Elizabeth A. Hubin
Mirjana Lilic
Seth A. Darst
Elizabeth A. Campbell
Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures
description Understanding of the mycobacterial transcription system is useful to the development of therapeutics against tuberculosis infection. Here the authors present the crystal structure of a completeM. smegmatisRNA polymerase open promoter complex that reveals unique features of the mycobacterial polymerase.
format article
author Elizabeth A. Hubin
Mirjana Lilic
Seth A. Darst
Elizabeth A. Campbell
author_facet Elizabeth A. Hubin
Mirjana Lilic
Seth A. Darst
Elizabeth A. Campbell
author_sort Elizabeth A. Hubin
title Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures
title_short Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures
title_full Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures
title_fullStr Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures
title_full_unstemmed Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures
title_sort structural insights into the mycobacteria transcription initiation complex from analysis of x-ray crystal structures
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/133287ec42704d49bf169ec537d59a2a
work_keys_str_mv AT elizabethahubin structuralinsightsintothemycobacteriatranscriptioninitiationcomplexfromanalysisofxraycrystalstructures
AT mirjanalilic structuralinsightsintothemycobacteriatranscriptioninitiationcomplexfromanalysisofxraycrystalstructures
AT sethadarst structuralinsightsintothemycobacteriatranscriptioninitiationcomplexfromanalysisofxraycrystalstructures
AT elizabethacampbell structuralinsightsintothemycobacteriatranscriptioninitiationcomplexfromanalysisofxraycrystalstructures
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