In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075

The bacterial pathogen Acinetobacter baumannii has evolved resistance to many antibiotics, including carbapenems. Here, Wu et al. show that the carbapenemase Oxa-23 interacts with the outer membrane porin CarO in an A. baumanniiisolate, indicative of porin-localised antibiotic inactivation.

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Autores principales:	Xia Wu, Juan D. Chavez, Devin K. Schweppe, Chunxiang Zheng, Chad R. Weisbrod, Jimmy K. Eng, Ananya Murali, Samuel A. Lee, Elizabeth Ramage, Larry A. Gallagher, Hemantha D. Kulasekara, Mauna E. Edrozo, Cassandra N. Kamischke, Mitchell J. Brittnacher, Samuel I. Miller, Pradeep K. Singh, Colin Manoil, James E. Bruce
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1333b90e086549de845305809266c010
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spelling	oai:doaj.org-article:1333b90e086549de845305809266c0102021-12-02T16:58:00ZIn vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB507510.1038/ncomms134142041-1723https://doaj.org/article/1333b90e086549de845305809266c0102016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13414https://doaj.org/toc/2041-1723The bacterial pathogen Acinetobacter baumannii has evolved resistance to many antibiotics, including carbapenems. Here, Wu et al. show that the carbapenemase Oxa-23 interacts with the outer membrane porin CarO in an A. baumanniiisolate, indicative of porin-localised antibiotic inactivation.Xia WuJuan D. ChavezDevin K. SchweppeChunxiang ZhengChad R. WeisbrodJimmy K. EngAnanya MuraliSamuel A. LeeElizabeth RamageLarry A. GallagherHemantha D. KulasekaraMauna E. EdrozoCassandra N. KamischkeMitchell J. BrittnacherSamuel I. MillerPradeep K. SinghColin ManoilJames E. BruceNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xia Wu Juan D. Chavez Devin K. Schweppe Chunxiang Zheng Chad R. Weisbrod Jimmy K. Eng Ananya Murali Samuel A. Lee Elizabeth Ramage Larry A. Gallagher Hemantha D. Kulasekara Mauna E. Edrozo Cassandra N. Kamischke Mitchell J. Brittnacher Samuel I. Miller Pradeep K. Singh Colin Manoil James E. Bruce In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075
description	The bacterial pathogen Acinetobacter baumannii has evolved resistance to many antibiotics, including carbapenems. Here, Wu et al. show that the carbapenemase Oxa-23 interacts with the outer membrane porin CarO in an A. baumanniiisolate, indicative of porin-localised antibiotic inactivation.
format	article
author	Xia Wu Juan D. Chavez Devin K. Schweppe Chunxiang Zheng Chad R. Weisbrod Jimmy K. Eng Ananya Murali Samuel A. Lee Elizabeth Ramage Larry A. Gallagher Hemantha D. Kulasekara Mauna E. Edrozo Cassandra N. Kamischke Mitchell J. Brittnacher Samuel I. Miller Pradeep K. Singh Colin Manoil James E. Bruce
author_facet	Xia Wu Juan D. Chavez Devin K. Schweppe Chunxiang Zheng Chad R. Weisbrod Jimmy K. Eng Ananya Murali Samuel A. Lee Elizabeth Ramage Larry A. Gallagher Hemantha D. Kulasekara Mauna E. Edrozo Cassandra N. Kamischke Mitchell J. Brittnacher Samuel I. Miller Pradeep K. Singh Colin Manoil James E. Bruce
author_sort	Xia Wu
title	In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075
title_short	In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075
title_full	In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075
title_fullStr	In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075
title_full_unstemmed	In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075
title_sort	in vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in acinetobacter baumannii strain ab5075
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1333b90e086549de845305809266c010
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In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075

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