EVALUATION OF CHONDROPROTECTIVE EFFECTS OF INTRA ARTICULAR PIROXICAM IN POST-TRAUMATIC OSTEOARTHRITIS MODEL OF RAT

Objective: To evaluate the chondroprotective effect of piroxicam in post-traumatic osteoarthritis model of rat. Study Design: Laboratory based experimental study. Place and Duration of Study: Pharmacology department, Army Medical College, Rawalpindi, from Apr to Jun 2019. Methodology: Proje...

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Autores principales:	Noaman Ishaq, Shabana Ali, Qurra Tul Ain Haider, Muhammad Abdul Basit Qaisrani, Komal Mumtaz Malik, Muhammad Wasiullah Khan
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	chondroprotective effects osteoarthritis piroxicam Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/13347c3c89da435da9855087a1af870c
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spelling	oai:doaj.org-article:13347c3c89da435da9855087a1af870c2021-12-02T18:44:47ZEVALUATION OF CHONDROPROTECTIVE EFFECTS OF INTRA ARTICULAR PIROXICAM IN POST-TRAUMATIC OSTEOARTHRITIS MODEL OF RAT0030-96482411-884210.51253/pafmj.v71i2.4625https://doaj.org/article/13347c3c89da435da9855087a1af870c2021-04-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/4625https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To evaluate the chondroprotective effect of piroxicam in post-traumatic osteoarthritis model of rat. Study Design: Laboratory based experimental study. Place and Duration of Study: Pharmacology department, Army Medical College, Rawalpindi, from Apr to Jun 2019. Methodology: Project included sixteen rats of Sprague Dawley breed. Osteoarthritis was induced in anesthetized rats by surgical removal of medial meniscus and anterior cruciate ligament resection. After that rats were randomly allocated in two groups with eight rats in each group. Rats of group I were positive control that received 0.2 ml saline intra articularly once weekly for four weeks. Meanwhile rats of group II (treatment group) received 50 µl piroxicam intra articularly once weekly for four weeks. One week after the drug intervention, radiograph of the right knee joint of all rats were taken. Animals were then sacrificed with inhaled chloroform and part of proximal tibia was obtained for histopathological analysis. Results: Comparison of radiographs of both groups depicted a significant p-value of <0.01. Meanwhile mean histopathological score of control group and treatment group were 11.50 ± 1.195 and 6.50 ± 1.195 respectively with a p-value of <0.01. Conclusion: Intra articular administration of piroxicam in post-traumatic Osteoarthritis model of rats resulted in improvement in radiographic grades and histopathology scores.Noaman IshaqShabana AliQurra Tul Ain HaiderMuhammad Abdul Basit QaisraniKomal Mumtaz MalikMuhammad Wasiullah KhanArmy Medical College Rawalpindiarticlechondroprotective effectsosteoarthritispiroxicamMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 2, Pp 593-97 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chondroprotective effects osteoarthritis piroxicam Medicine R Medicine (General) R5-920
spellingShingle	chondroprotective effects osteoarthritis piroxicam Medicine R Medicine (General) R5-920 Noaman Ishaq Shabana Ali Qurra Tul Ain Haider Muhammad Abdul Basit Qaisrani Komal Mumtaz Malik Muhammad Wasiullah Khan EVALUATION OF CHONDROPROTECTIVE EFFECTS OF INTRA ARTICULAR PIROXICAM IN POST-TRAUMATIC OSTEOARTHRITIS MODEL OF RAT
description	Objective: To evaluate the chondroprotective effect of piroxicam in post-traumatic osteoarthritis model of rat. Study Design: Laboratory based experimental study. Place and Duration of Study: Pharmacology department, Army Medical College, Rawalpindi, from Apr to Jun 2019. Methodology: Project included sixteen rats of Sprague Dawley breed. Osteoarthritis was induced in anesthetized rats by surgical removal of medial meniscus and anterior cruciate ligament resection. After that rats were randomly allocated in two groups with eight rats in each group. Rats of group I were positive control that received 0.2 ml saline intra articularly once weekly for four weeks. Meanwhile rats of group II (treatment group) received 50 µl piroxicam intra articularly once weekly for four weeks. One week after the drug intervention, radiograph of the right knee joint of all rats were taken. Animals were then sacrificed with inhaled chloroform and part of proximal tibia was obtained for histopathological analysis. Results: Comparison of radiographs of both groups depicted a significant p-value of <0.01. Meanwhile mean histopathological score of control group and treatment group were 11.50 ± 1.195 and 6.50 ± 1.195 respectively with a p-value of <0.01. Conclusion: Intra articular administration of piroxicam in post-traumatic Osteoarthritis model of rats resulted in improvement in radiographic grades and histopathology scores.
format	article
author	Noaman Ishaq Shabana Ali Qurra Tul Ain Haider Muhammad Abdul Basit Qaisrani Komal Mumtaz Malik Muhammad Wasiullah Khan
author_facet	Noaman Ishaq Shabana Ali Qurra Tul Ain Haider Muhammad Abdul Basit Qaisrani Komal Mumtaz Malik Muhammad Wasiullah Khan
author_sort	Noaman Ishaq
title	EVALUATION OF CHONDROPROTECTIVE EFFECTS OF INTRA ARTICULAR PIROXICAM IN POST-TRAUMATIC OSTEOARTHRITIS MODEL OF RAT
title_short	EVALUATION OF CHONDROPROTECTIVE EFFECTS OF INTRA ARTICULAR PIROXICAM IN POST-TRAUMATIC OSTEOARTHRITIS MODEL OF RAT
title_full	EVALUATION OF CHONDROPROTECTIVE EFFECTS OF INTRA ARTICULAR PIROXICAM IN POST-TRAUMATIC OSTEOARTHRITIS MODEL OF RAT
title_fullStr	EVALUATION OF CHONDROPROTECTIVE EFFECTS OF INTRA ARTICULAR PIROXICAM IN POST-TRAUMATIC OSTEOARTHRITIS MODEL OF RAT
title_full_unstemmed	EVALUATION OF CHONDROPROTECTIVE EFFECTS OF INTRA ARTICULAR PIROXICAM IN POST-TRAUMATIC OSTEOARTHRITIS MODEL OF RAT
title_sort	evaluation of chondroprotective effects of intra articular piroxicam in post-traumatic osteoarthritis model of rat
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/13347c3c89da435da9855087a1af870c
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EVALUATION OF CHONDROPROTECTIVE EFFECTS OF INTRA ARTICULAR PIROXICAM IN POST-TRAUMATIC OSTEOARTHRITIS MODEL OF RAT

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