Alkaline phosphatase assessing in differentiation of exudative from transudative pleural effusion

Background and Objective: Light criteria (Protein and LDH) and cholesterol is commonly used to differentiate exudative from transudative pleural effusion. Application of both parameters is time consuming and relatively expensive. This study was done to determine the role of alkaline phosphatase (ALP...

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Autores principales:	T Esmaeil Nia, KH Bijani, M Haji Ahmadi, B Hosseini
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2002
Materias:	pleural fluid alkaline phosphatase exudate transudate lactate dehydrogenase Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1334fcfda6c744bc896e3a0fc5dbc03a
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spelling	oai:doaj.org-article:1334fcfda6c744bc896e3a0fc5dbc03a2021-11-10T09:19:48ZAlkaline phosphatase assessing in differentiation of exudative from transudative pleural effusion1561-41072251-7170https://doaj.org/article/1334fcfda6c744bc896e3a0fc5dbc03a2002-10-01T00:00:00Zhttp://jbums.org/article-1-2807-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Light criteria (Protein and LDH) and cholesterol is commonly used to differentiate exudative from transudative pleural effusion. Application of both parameters is time consuming and relatively expensive. This study was done to determine the role of alkaline phosphatase (ALP) assessment in differentiation of exudative from transudative pleural effusion and the comparison with light criteria and cholesterol. Methods: This study was performed on all patients with pleural effusion referred to Shahid Beheshti hospital (Babol, Iran) during 1998-2001. Biological (Protein, LDH, cholesterol and alkaline phosphatase), cytologic and bacteriologic tests were performed on all pleural fluid and blood samples of patients. Sixty-four patients were followed up till final diagnosis. The results of light criteria and cholesterol were compared to alkaline phosphatase activity according to accuracy and sensitivity of separation of pleural effusion. Findings: In 43 patients (67%), pleural effusions were exudates and in 21 patients (33%) were transudates. The parameter of alkaline phosphatase in dissociation of exudative from transudative pleural effusion had a sensitivity, specificity and accuracy of 88%, 100% and 90%, respectively while light criteria was with sensitivity of 96% and specificity of 77%. Conclusion: ALP revealed a similar accuracy to light criteria in exudative pleural effusion diagnosis. Because of higher specificity for ALP than light criteria, it will be more accurate in differentiation of transudative from exudative pleural effusion.T Esmaeil NiaKH BijaniM Haji AhmadiB HosseiniBabol University of Medical Sciencesarticlepleural fluidalkaline phosphataseexudatetransudatelactate dehydrogenaseMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 4, Iss 4, Pp 17-21 (2002)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	pleural fluid alkaline phosphatase exudate transudate lactate dehydrogenase Medicine R Medicine (General) R5-920
spellingShingle	pleural fluid alkaline phosphatase exudate transudate lactate dehydrogenase Medicine R Medicine (General) R5-920 T Esmaeil Nia KH Bijani M Haji Ahmadi B Hosseini Alkaline phosphatase assessing in differentiation of exudative from transudative pleural effusion
description	Background and Objective: Light criteria (Protein and LDH) and cholesterol is commonly used to differentiate exudative from transudative pleural effusion. Application of both parameters is time consuming and relatively expensive. This study was done to determine the role of alkaline phosphatase (ALP) assessment in differentiation of exudative from transudative pleural effusion and the comparison with light criteria and cholesterol. Methods: This study was performed on all patients with pleural effusion referred to Shahid Beheshti hospital (Babol, Iran) during 1998-2001. Biological (Protein, LDH, cholesterol and alkaline phosphatase), cytologic and bacteriologic tests were performed on all pleural fluid and blood samples of patients. Sixty-four patients were followed up till final diagnosis. The results of light criteria and cholesterol were compared to alkaline phosphatase activity according to accuracy and sensitivity of separation of pleural effusion. Findings: In 43 patients (67%), pleural effusions were exudates and in 21 patients (33%) were transudates. The parameter of alkaline phosphatase in dissociation of exudative from transudative pleural effusion had a sensitivity, specificity and accuracy of 88%, 100% and 90%, respectively while light criteria was with sensitivity of 96% and specificity of 77%. Conclusion: ALP revealed a similar accuracy to light criteria in exudative pleural effusion diagnosis. Because of higher specificity for ALP than light criteria, it will be more accurate in differentiation of transudative from exudative pleural effusion.
format	article
author	T Esmaeil Nia KH Bijani M Haji Ahmadi B Hosseini
author_facet	T Esmaeil Nia KH Bijani M Haji Ahmadi B Hosseini
author_sort	T Esmaeil Nia
title	Alkaline phosphatase assessing in differentiation of exudative from transudative pleural effusion
title_short	Alkaline phosphatase assessing in differentiation of exudative from transudative pleural effusion
title_full	Alkaline phosphatase assessing in differentiation of exudative from transudative pleural effusion
title_fullStr	Alkaline phosphatase assessing in differentiation of exudative from transudative pleural effusion
title_full_unstemmed	Alkaline phosphatase assessing in differentiation of exudative from transudative pleural effusion
title_sort	alkaline phosphatase assessing in differentiation of exudative from transudative pleural effusion
publisher	Babol University of Medical Sciences
publishDate	2002
url	https://doaj.org/article/1334fcfda6c744bc896e3a0fc5dbc03a
work_keys_str_mv	AT tesmaeilnia alkalinephosphataseassessingindifferentiationofexudativefromtransudativepleuraleffusion AT khbijani alkalinephosphataseassessingindifferentiationofexudativefromtransudativepleuraleffusion AT mhajiahmadi alkalinephosphataseassessingindifferentiationofexudativefromtransudativepleuraleffusion AT bhosseini alkalinephosphataseassessingindifferentiationofexudativefromtransudativepleuraleffusion
_version_	1718440077624868864

Alkaline phosphatase assessing in differentiation of exudative from transudative pleural effusion

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