Study of Correlation of Cytomorphological Features of Lymphocytic Thyroiditis with Biochemical Parameters and Vitamin D Deficiency
Introduction: Fine Needle Aspiration Cytology (FNAC) of the thyroid is a reliable and common method used for diagnosis of chronic Lymphocytic Thyroiditis (LT) which is an autoimmune disease. Vitamin D (Vit D) deficiency, a prevalent health problem, is known to have correlation with various autoi...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
JCDR Research and Publications Private Limited
2021
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| Acceso en línea: | https://doaj.org/article/13365d544e8b46f29c94fd95be453c1a |
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| Sumario: | Introduction: Fine Needle Aspiration Cytology (FNAC) of the
thyroid is a reliable and common method used for diagnosis of
chronic Lymphocytic Thyroiditis (LT) which is an autoimmune
disease. Vitamin D (Vit D) deficiency, a prevalent health problem,
is known to have correlation with various autoimmune diseases
especially chronic LT.
Aim: To evaluate the relationship between Vit D levels, biochemical
parameters with cytomorphological features of LT.
Materials and Methods: The present cohort study was conducted
on 88 patients with cytological evidence of LT at a thyroid research
centre in northern India between June 2017 to September 2018.
Thyroid Stimulating Hormone (TSH), Antithyroid Peroxidase (ATPO)
Antibody and Vit D levels along with patient’s clinical presentation,
and thyroid ultrasound were evaluated for all subjects. The cytological
grades and other cytomorphological features were correlated with
these parameters.
Results: Most of the patients were females (82, 93.2%) who
presented with diffuse thyromegaly (69, 78.4%) and had
hypothyroidism (58, 65.9%). By cytology grade I thyroiditis
(40, 45.5%) was commonest followed by grade II (38, 43.2%).
The Vit D deficiency and elevated ATPO were seen in 72 (81.8%)
and 78 (88.6%) patients, respectively. Lowest level of Vit D
(7.8±4.9 ng/mL) was seen in grade III patients. Significant
correlation was observed between ATPO and Vit D levels
with cytomorphological grades and some cytomorphological
features like Hurthle cell change and plasma cells presence.
While TSH levels correlated significantly with cytological grades
only in hypothyroid group.
Conclusion: This study found that Vit D deficiency and ATPO
levels significantly correlates with cytological grades of thyroiditis
and affect certain cytomorphological features like plasma cells
presence, suggesting lower levels of Vit D and higher ATPO may
be related to more active disease. |
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