Study of Correlation of Cytomorphological Features of Lymphocytic Thyroiditis with Biochemical Parameters and Vitamin D Deficiency

Introduction: Fine Needle Aspiration Cytology (FNAC) of the thyroid is a reliable and common method used for diagnosis of chronic Lymphocytic Thyroiditis (LT) which is an autoimmune disease. Vitamin D (Vit D) deficiency, a prevalent health problem, is known to have correlation with various autoi...

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Autores principales:	Preeti Patni, Shreeshail Belagavi, Priyanka Mishra, Tanu Choudhary
Formato:	article
Lenguaje:	EN
Publicado:	JCDR Research and Publications Private Limited 2021
Materias:	antithyroid peroxidase antibody cytological grades hurthle cell Medicine R
Acceso en línea:	https://doaj.org/article/13365d544e8b46f29c94fd95be453c1a
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spelling	oai:doaj.org-article:13365d544e8b46f29c94fd95be453c1a2021-11-08T02:13:25ZStudy of Correlation of Cytomorphological Features of Lymphocytic Thyroiditis with Biochemical Parameters and Vitamin D Deficiency10.7860/JCDR/2021/48991.153582249-782X0973-709Xhttps://doaj.org/article/13365d544e8b46f29c94fd95be453c1a2021-09-01T00:00:00Zhttps://www.jcdr.net/articles/PDF/15358/48991_CE[Ra1]_F[SK]_PF1(AG_SL)_PFA(KM)_PB(AG_KM_PN(KM).pdfhttps://doaj.org/toc/2249-782Xhttps://doaj.org/toc/0973-709XIntroduction: Fine Needle Aspiration Cytology (FNAC) of the thyroid is a reliable and common method used for diagnosis of chronic Lymphocytic Thyroiditis (LT) which is an autoimmune disease. Vitamin D (Vit D) deficiency, a prevalent health problem, is known to have correlation with various autoimmune diseases especially chronic LT. Aim: To evaluate the relationship between Vit D levels, biochemical parameters with cytomorphological features of LT. Materials and Methods: The present cohort study was conducted on 88 patients with cytological evidence of LT at a thyroid research centre in northern India between June 2017 to September 2018. Thyroid Stimulating Hormone (TSH), Antithyroid Peroxidase (ATPO) Antibody and Vit D levels along with patient’s clinical presentation, and thyroid ultrasound were evaluated for all subjects. The cytological grades and other cytomorphological features were correlated with these parameters. Results: Most of the patients were females (82, 93.2%) who presented with diffuse thyromegaly (69, 78.4%) and had hypothyroidism (58, 65.9%). By cytology grade I thyroiditis (40, 45.5%) was commonest followed by grade II (38, 43.2%). The Vit D deficiency and elevated ATPO were seen in 72 (81.8%) and 78 (88.6%) patients, respectively. Lowest level of Vit D (7.8±4.9 ng/mL) was seen in grade III patients. Significant correlation was observed between ATPO and Vit D levels with cytomorphological grades and some cytomorphological features like Hurthle cell change and plasma cells presence. While TSH levels correlated significantly with cytological grades only in hypothyroid group. Conclusion: This study found that Vit D deficiency and ATPO levels significantly correlates with cytological grades of thyroiditis and affect certain cytomorphological features like plasma cells presence, suggesting lower levels of Vit D and higher ATPO may be related to more active disease.Preeti PatniShreeshail BelagaviPriyanka MishraTanu ChoudharyJCDR Research and Publications Private Limitedarticleantithyroid peroxidase antibodycytological gradeshurthle cellMedicineRENJournal of Clinical and Diagnostic Research, Vol 15, Iss 9, Pp EC05-EC09 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antithyroid peroxidase antibody cytological grades hurthle cell Medicine R
spellingShingle	antithyroid peroxidase antibody cytological grades hurthle cell Medicine R Preeti Patni Shreeshail Belagavi Priyanka Mishra Tanu Choudhary Study of Correlation of Cytomorphological Features of Lymphocytic Thyroiditis with Biochemical Parameters and Vitamin D Deficiency
description	Introduction: Fine Needle Aspiration Cytology (FNAC) of the thyroid is a reliable and common method used for diagnosis of chronic Lymphocytic Thyroiditis (LT) which is an autoimmune disease. Vitamin D (Vit D) deficiency, a prevalent health problem, is known to have correlation with various autoimmune diseases especially chronic LT. Aim: To evaluate the relationship between Vit D levels, biochemical parameters with cytomorphological features of LT. Materials and Methods: The present cohort study was conducted on 88 patients with cytological evidence of LT at a thyroid research centre in northern India between June 2017 to September 2018. Thyroid Stimulating Hormone (TSH), Antithyroid Peroxidase (ATPO) Antibody and Vit D levels along with patient’s clinical presentation, and thyroid ultrasound were evaluated for all subjects. The cytological grades and other cytomorphological features were correlated with these parameters. Results: Most of the patients were females (82, 93.2%) who presented with diffuse thyromegaly (69, 78.4%) and had hypothyroidism (58, 65.9%). By cytology grade I thyroiditis (40, 45.5%) was commonest followed by grade II (38, 43.2%). The Vit D deficiency and elevated ATPO were seen in 72 (81.8%) and 78 (88.6%) patients, respectively. Lowest level of Vit D (7.8±4.9 ng/mL) was seen in grade III patients. Significant correlation was observed between ATPO and Vit D levels with cytomorphological grades and some cytomorphological features like Hurthle cell change and plasma cells presence. While TSH levels correlated significantly with cytological grades only in hypothyroid group. Conclusion: This study found that Vit D deficiency and ATPO levels significantly correlates with cytological grades of thyroiditis and affect certain cytomorphological features like plasma cells presence, suggesting lower levels of Vit D and higher ATPO may be related to more active disease.
format	article
author	Preeti Patni Shreeshail Belagavi Priyanka Mishra Tanu Choudhary
author_facet	Preeti Patni Shreeshail Belagavi Priyanka Mishra Tanu Choudhary
author_sort	Preeti Patni
title	Study of Correlation of Cytomorphological Features of Lymphocytic Thyroiditis with Biochemical Parameters and Vitamin D Deficiency
title_short	Study of Correlation of Cytomorphological Features of Lymphocytic Thyroiditis with Biochemical Parameters and Vitamin D Deficiency
title_full	Study of Correlation of Cytomorphological Features of Lymphocytic Thyroiditis with Biochemical Parameters and Vitamin D Deficiency
title_fullStr	Study of Correlation of Cytomorphological Features of Lymphocytic Thyroiditis with Biochemical Parameters and Vitamin D Deficiency
title_full_unstemmed	Study of Correlation of Cytomorphological Features of Lymphocytic Thyroiditis with Biochemical Parameters and Vitamin D Deficiency
title_sort	study of correlation of cytomorphological features of lymphocytic thyroiditis with biochemical parameters and vitamin d deficiency
publisher	JCDR Research and Publications Private Limited
publishDate	2021
url	https://doaj.org/article/13365d544e8b46f29c94fd95be453c1a
work_keys_str_mv	AT preetipatni studyofcorrelationofcytomorphologicalfeaturesoflymphocyticthyroiditiswithbiochemicalparametersandvitaminddeficiency AT shreeshailbelagavi studyofcorrelationofcytomorphologicalfeaturesoflymphocyticthyroiditiswithbiochemicalparametersandvitaminddeficiency AT priyankamishra studyofcorrelationofcytomorphologicalfeaturesoflymphocyticthyroiditiswithbiochemicalparametersandvitaminddeficiency AT tanuchoudhary studyofcorrelationofcytomorphologicalfeaturesoflymphocyticthyroiditiswithbiochemicalparametersandvitaminddeficiency
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Study of Correlation of Cytomorphological Features of Lymphocytic Thyroiditis with Biochemical Parameters and Vitamin D Deficiency

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