Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection

Abstract Little is known about the incidence of metachronous advanced neoplasia (AN) following resection of submucosal invasive colorectal cancer (SM-CRC). Here, we aimed to assess the occurrence of metachronous AN following SM-CRC resection. We retrospectively reviewed consecutive patients who unde...

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Autores principales:	Tatsunori Minamide, Hiroaki Ikematsu, Tatsuro Murano, Tomohiro Kadota, Kensuke Shinmura, Yusuke Yoda, Keisuke Hori, Masaaki Ito, Tomonori Yano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/133bc41459b04373a57e26a3e0349ca7
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spelling	oai:doaj.org-article:133bc41459b04373a57e26a3e0349ca72021-12-02T13:50:50ZMetachronous advanced neoplasia after submucosal invasive colorectal cancer resection10.1038/s41598-021-81645-22045-2322https://doaj.org/article/133bc41459b04373a57e26a3e0349ca72021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81645-2https://doaj.org/toc/2045-2322Abstract Little is known about the incidence of metachronous advanced neoplasia (AN) following resection of submucosal invasive colorectal cancer (SM-CRC). Here, we aimed to assess the occurrence of metachronous AN following SM-CRC resection. We retrospectively reviewed consecutive patients who underwent SM-CRC resection at an academic medical center between 2005 and 2013. Among 343 patients, 250 (72.9%) underwent surgical resection or endoscopic resection followed by surgical resection and 93 (27.1%) underwent only endoscopic resection. During a median follow-up period of 61.5 months, the overall incidence of metachronous AN was 7.6%, and the cumulative incidence at 5 years was 6.1%. The cumulative incidence was significantly higher in the endoscopic resection group than in surgical resection group, in patients with colonic disease than in those with rectal disease, and in patients with synchronous AN than in those without. Multivariate analysis revealed that synchronous AN was the only significant risk factor for metachronous AN (HR 4.35; 95% CI 1.88–10.1). These findings imply that depending on synchronous AN, a surveillance protocol following SM-CRC resection can be changed for better detection of metachronous AN.Tatsunori MinamideHiroaki IkematsuTatsuro MuranoTomohiro KadotaKensuke ShinmuraYusuke YodaKeisuke HoriMasaaki ItoTomonori YanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tatsunori Minamide Hiroaki Ikematsu Tatsuro Murano Tomohiro Kadota Kensuke Shinmura Yusuke Yoda Keisuke Hori Masaaki Ito Tomonori Yano Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
description	Abstract Little is known about the incidence of metachronous advanced neoplasia (AN) following resection of submucosal invasive colorectal cancer (SM-CRC). Here, we aimed to assess the occurrence of metachronous AN following SM-CRC resection. We retrospectively reviewed consecutive patients who underwent SM-CRC resection at an academic medical center between 2005 and 2013. Among 343 patients, 250 (72.9%) underwent surgical resection or endoscopic resection followed by surgical resection and 93 (27.1%) underwent only endoscopic resection. During a median follow-up period of 61.5 months, the overall incidence of metachronous AN was 7.6%, and the cumulative incidence at 5 years was 6.1%. The cumulative incidence was significantly higher in the endoscopic resection group than in surgical resection group, in patients with colonic disease than in those with rectal disease, and in patients with synchronous AN than in those without. Multivariate analysis revealed that synchronous AN was the only significant risk factor for metachronous AN (HR 4.35; 95% CI 1.88–10.1). These findings imply that depending on synchronous AN, a surveillance protocol following SM-CRC resection can be changed for better detection of metachronous AN.
format	article
author	Tatsunori Minamide Hiroaki Ikematsu Tatsuro Murano Tomohiro Kadota Kensuke Shinmura Yusuke Yoda Keisuke Hori Masaaki Ito Tomonori Yano
author_facet	Tatsunori Minamide Hiroaki Ikematsu Tatsuro Murano Tomohiro Kadota Kensuke Shinmura Yusuke Yoda Keisuke Hori Masaaki Ito Tomonori Yano
author_sort	Tatsunori Minamide
title	Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
title_short	Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
title_full	Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
title_fullStr	Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
title_full_unstemmed	Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
title_sort	metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/133bc41459b04373a57e26a3e0349ca7
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Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection

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