Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection

Abstract Little is known about the incidence of metachronous advanced neoplasia (AN) following resection of submucosal invasive colorectal cancer (SM-CRC). Here, we aimed to assess the occurrence of metachronous AN following SM-CRC resection. We retrospectively reviewed consecutive patients who unde...

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Autores principales: Tatsunori Minamide, Hiroaki Ikematsu, Tatsuro Murano, Tomohiro Kadota, Kensuke Shinmura, Yusuke Yoda, Keisuke Hori, Masaaki Ito, Tomonori Yano
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/133bc41459b04373a57e26a3e0349ca7
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spelling oai:doaj.org-article:133bc41459b04373a57e26a3e0349ca72021-12-02T13:50:50ZMetachronous advanced neoplasia after submucosal invasive colorectal cancer resection10.1038/s41598-021-81645-22045-2322https://doaj.org/article/133bc41459b04373a57e26a3e0349ca72021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81645-2https://doaj.org/toc/2045-2322Abstract Little is known about the incidence of metachronous advanced neoplasia (AN) following resection of submucosal invasive colorectal cancer (SM-CRC). Here, we aimed to assess the occurrence of metachronous AN following SM-CRC resection. We retrospectively reviewed consecutive patients who underwent SM-CRC resection at an academic medical center between 2005 and 2013. Among 343 patients, 250 (72.9%) underwent surgical resection or endoscopic resection followed by surgical resection and 93 (27.1%) underwent only endoscopic resection. During a median follow-up period of 61.5 months, the overall incidence of metachronous AN was 7.6%, and the cumulative incidence at 5 years was 6.1%. The cumulative incidence was significantly higher in the endoscopic resection group than in surgical resection group, in patients with colonic disease than in those with rectal disease, and in patients with synchronous AN than in those without. Multivariate analysis revealed that synchronous AN was the only significant risk factor for metachronous AN (HR 4.35; 95% CI 1.88–10.1). These findings imply that depending on synchronous AN, a surveillance protocol following SM-CRC resection can be changed for better detection of metachronous AN.Tatsunori MinamideHiroaki IkematsuTatsuro MuranoTomohiro KadotaKensuke ShinmuraYusuke YodaKeisuke HoriMasaaki ItoTomonori YanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Tatsunori Minamide
Hiroaki Ikematsu
Tatsuro Murano
Tomohiro Kadota
Kensuke Shinmura
Yusuke Yoda
Keisuke Hori
Masaaki Ito
Tomonori Yano
Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
description Abstract Little is known about the incidence of metachronous advanced neoplasia (AN) following resection of submucosal invasive colorectal cancer (SM-CRC). Here, we aimed to assess the occurrence of metachronous AN following SM-CRC resection. We retrospectively reviewed consecutive patients who underwent SM-CRC resection at an academic medical center between 2005 and 2013. Among 343 patients, 250 (72.9%) underwent surgical resection or endoscopic resection followed by surgical resection and 93 (27.1%) underwent only endoscopic resection. During a median follow-up period of 61.5 months, the overall incidence of metachronous AN was 7.6%, and the cumulative incidence at 5 years was 6.1%. The cumulative incidence was significantly higher in the endoscopic resection group than in surgical resection group, in patients with colonic disease than in those with rectal disease, and in patients with synchronous AN than in those without. Multivariate analysis revealed that synchronous AN was the only significant risk factor for metachronous AN (HR 4.35; 95% CI 1.88–10.1). These findings imply that depending on synchronous AN, a surveillance protocol following SM-CRC resection can be changed for better detection of metachronous AN.
format article
author Tatsunori Minamide
Hiroaki Ikematsu
Tatsuro Murano
Tomohiro Kadota
Kensuke Shinmura
Yusuke Yoda
Keisuke Hori
Masaaki Ito
Tomonori Yano
author_facet Tatsunori Minamide
Hiroaki Ikematsu
Tatsuro Murano
Tomohiro Kadota
Kensuke Shinmura
Yusuke Yoda
Keisuke Hori
Masaaki Ito
Tomonori Yano
author_sort Tatsunori Minamide
title Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
title_short Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
title_full Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
title_fullStr Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
title_full_unstemmed Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
title_sort metachronous advanced neoplasia after submucosal invasive colorectal cancer resection
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/133bc41459b04373a57e26a3e0349ca7
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