Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis

Herpesviruses code for conserved protein kinases (CHPKs) that exert several regulatory functions by interacting with cellular factors. Here, the authors use affinity purification mass spectrometry (AP–MS) to identify differential interaction partners of CHPKs from seven different human herpesviruses...

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Autores principales:	Boris Bogdanow, Max Schmidt, Henry Weisbach, Iris Gruska, Barbara Vetter, Koshi Imami, Eleonore Ostermann, Wolfram Brune, Matthias Selbach, Christian Hagemeier, Lüder Wiebusch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/133fc29f23204b0791dbb8300482ea71
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spelling	oai:doaj.org-article:133fc29f23204b0791dbb8300482ea712021-12-02T18:13:46ZCross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis10.1038/s41467-020-18542-12041-1723https://doaj.org/article/133fc29f23204b0791dbb8300482ea712020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18542-1https://doaj.org/toc/2041-1723Herpesviruses code for conserved protein kinases (CHPKs) that exert several regulatory functions by interacting with cellular factors. Here, the authors use affinity purification mass spectrometry (AP–MS) to identify differential interaction partners of CHPKs from seven different human herpesviruses, finding Cyclin A and associated factors as a specific signature of β-herpesvirus kinases.Boris BogdanowMax SchmidtHenry WeisbachIris GruskaBarbara VetterKoshi ImamiEleonore OstermannWolfram BruneMatthias SelbachChristian HagemeierLüder WiebuschNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Boris Bogdanow Max Schmidt Henry Weisbach Iris Gruska Barbara Vetter Koshi Imami Eleonore Ostermann Wolfram Brune Matthias Selbach Christian Hagemeier Lüder Wiebusch Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
description	Herpesviruses code for conserved protein kinases (CHPKs) that exert several regulatory functions by interacting with cellular factors. Here, the authors use affinity purification mass spectrometry (AP–MS) to identify differential interaction partners of CHPKs from seven different human herpesviruses, finding Cyclin A and associated factors as a specific signature of β-herpesvirus kinases.
format	article
author	Boris Bogdanow Max Schmidt Henry Weisbach Iris Gruska Barbara Vetter Koshi Imami Eleonore Ostermann Wolfram Brune Matthias Selbach Christian Hagemeier Lüder Wiebusch
author_facet	Boris Bogdanow Max Schmidt Henry Weisbach Iris Gruska Barbara Vetter Koshi Imami Eleonore Ostermann Wolfram Brune Matthias Selbach Christian Hagemeier Lüder Wiebusch
author_sort	Boris Bogdanow
title	Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
title_short	Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
title_full	Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
title_fullStr	Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
title_full_unstemmed	Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
title_sort	cross-regulation of viral kinases with cyclin a secures shutoff of host dna synthesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/133fc29f23204b0791dbb8300482ea71
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Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis

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