Innate-Immunity Genes in Obesity

The main functions of adipose tissue are thought to be storage and mobilization of the body’s energy reserves, active and passive thermoregulation, participation in the spatial organization of internal organs, protection of the body from lipotoxicity, and ectopic lipid deposition. After the discover...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Svetlana V. Mikhailova, Dinara E. Ivanoshchuk
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	obesity adipose tissue innate immunity gene knockout polymorphism genetic predisposition Medicine R
Acceso en línea:	https://doaj.org/article/13401a1a8730445ca96aad7f45df143f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:13401a1a8730445ca96aad7f45df143f
record_format	dspace
spelling	oai:doaj.org-article:13401a1a8730445ca96aad7f45df143f2021-11-25T18:07:58ZInnate-Immunity Genes in Obesity10.3390/jpm111112012075-4426https://doaj.org/article/13401a1a8730445ca96aad7f45df143f2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1201https://doaj.org/toc/2075-4426The main functions of adipose tissue are thought to be storage and mobilization of the body’s energy reserves, active and passive thermoregulation, participation in the spatial organization of internal organs, protection of the body from lipotoxicity, and ectopic lipid deposition. After the discovery of adipokines, the endocrine function was added to the above list, and after the identification of crosstalk between adipocytes and immune cells, an immune function was suggested. Nonetheless, it turned out that the mechanisms underlying mutual regulatory relations of adipocytes, preadipocytes, immune cells, and their microenvironment are complex and redundant at many levels. One possible way to elucidate the picture of adipose-tissue regulation is to determine genetic variants correlating with obesity. In this review, we examine various aspects of adipose-tissue involvement in innate immune responses as well as variants of immune-response genes associated with obesity.Svetlana V. MikhailovaDinara E. IvanoshchukMDPI AGarticleobesityadipose tissueinnate immunitygene knockoutpolymorphismgenetic predispositionMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1201, p 1201 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity adipose tissue innate immunity gene knockout polymorphism genetic predisposition Medicine R
spellingShingle	obesity adipose tissue innate immunity gene knockout polymorphism genetic predisposition Medicine R Svetlana V. Mikhailova Dinara E. Ivanoshchuk Innate-Immunity Genes in Obesity
description	The main functions of adipose tissue are thought to be storage and mobilization of the body’s energy reserves, active and passive thermoregulation, participation in the spatial organization of internal organs, protection of the body from lipotoxicity, and ectopic lipid deposition. After the discovery of adipokines, the endocrine function was added to the above list, and after the identification of crosstalk between adipocytes and immune cells, an immune function was suggested. Nonetheless, it turned out that the mechanisms underlying mutual regulatory relations of adipocytes, preadipocytes, immune cells, and their microenvironment are complex and redundant at many levels. One possible way to elucidate the picture of adipose-tissue regulation is to determine genetic variants correlating with obesity. In this review, we examine various aspects of adipose-tissue involvement in innate immune responses as well as variants of immune-response genes associated with obesity.
format	article
author	Svetlana V. Mikhailova Dinara E. Ivanoshchuk
author_facet	Svetlana V. Mikhailova Dinara E. Ivanoshchuk
author_sort	Svetlana V. Mikhailova
title	Innate-Immunity Genes in Obesity
title_short	Innate-Immunity Genes in Obesity
title_full	Innate-Immunity Genes in Obesity
title_fullStr	Innate-Immunity Genes in Obesity
title_full_unstemmed	Innate-Immunity Genes in Obesity
title_sort	innate-immunity genes in obesity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/13401a1a8730445ca96aad7f45df143f
work_keys_str_mv	AT svetlanavmikhailova innateimmunitygenesinobesity AT dinaraeivanoshchuk innateimmunitygenesinobesity
_version_	1718411544069406720

Innate-Immunity Genes in Obesity

Ejemplares similares