Multicolor imaging in central serous chorioretinopathy – a quantitative and qualitative comparison with fundus autofluorescence

Abstract Central serous chorioretinopathy (CSCR) is characterised by choroidal hyperpermeability which results in neurosensory detachments (NSD) along with numerous retinal pigment epithelium (RPE) alterations such as RPE atrophy. Fundus autofluorescence (FAF) demonstrates the functionality of the R...

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Autores principales:	Vishal Govindahari, Sumit Randhir Singh, Bindu Rajesh, Roberto Gallego-Pinazo, Rosa Dolz Marco, Dhanya V. Nair, Unni Nair, Jay Chhablani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1341c2ce7b144b6793ba223c69e49deb
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spelling	oai:doaj.org-article:1341c2ce7b144b6793ba223c69e49deb2021-12-02T16:08:28ZMulticolor imaging in central serous chorioretinopathy – a quantitative and qualitative comparison with fundus autofluorescence10.1038/s41598-019-48040-42045-2322https://doaj.org/article/1341c2ce7b144b6793ba223c69e49deb2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48040-4https://doaj.org/toc/2045-2322Abstract Central serous chorioretinopathy (CSCR) is characterised by choroidal hyperpermeability which results in neurosensory detachments (NSD) along with numerous retinal pigment epithelium (RPE) alterations such as RPE atrophy. Fundus autofluorescence (FAF) demonstrates the functionality of the RPE while multicolor imaging(MCI), by means of its three incident wavelengths, provides insight into clinical changes at various levels of the retina and choroid in CSCR. This study compares various clinical findings in CSCR (NSD, subretinal deposits, RPE atrophy, pigment epithelial detachments (PED) and pachyvessels) on the above mentioned imaging modalities both qualitatively and quantitatively. MCI showed higher mean cumulative area of RPE atrophic patches (6.3 ± 6.02 vs 5.7 ± 5.7 mm2, p = 0.046), PED (1.3 ± 1.4 vs 1.1 ± 1.2 mm2, p = 0.068) and NSD (17.2 ± 11.4 vs 15.7 ± 10.7 mm2, p = 0.033). MCI demonstrated better defined lesions (NSD, PED, RPE atrophy) and more number of eyes with PED and pachyvessels in comparison to FAF.Both investigations had a 100% sensitivity in detecting NSD and 100% specificity for sub retinal deposits. This study demonstrates the ability of MCI to quantitatively and qualitatively define various clinical features in CSCR and the advantages it holds over FAF. MCI can hence be considered as a useful imaging modality in documenting and monitoring various structural changes in eyes with CSCR.Vishal GovindahariSumit Randhir SinghBindu RajeshRoberto Gallego-PinazoRosa Dolz MarcoDhanya V. NairUnni NairJay ChhablaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vishal Govindahari Sumit Randhir Singh Bindu Rajesh Roberto Gallego-Pinazo Rosa Dolz Marco Dhanya V. Nair Unni Nair Jay Chhablani Multicolor imaging in central serous chorioretinopathy – a quantitative and qualitative comparison with fundus autofluorescence
description	Abstract Central serous chorioretinopathy (CSCR) is characterised by choroidal hyperpermeability which results in neurosensory detachments (NSD) along with numerous retinal pigment epithelium (RPE) alterations such as RPE atrophy. Fundus autofluorescence (FAF) demonstrates the functionality of the RPE while multicolor imaging(MCI), by means of its three incident wavelengths, provides insight into clinical changes at various levels of the retina and choroid in CSCR. This study compares various clinical findings in CSCR (NSD, subretinal deposits, RPE atrophy, pigment epithelial detachments (PED) and pachyvessels) on the above mentioned imaging modalities both qualitatively and quantitatively. MCI showed higher mean cumulative area of RPE atrophic patches (6.3 ± 6.02 vs 5.7 ± 5.7 mm2, p = 0.046), PED (1.3 ± 1.4 vs 1.1 ± 1.2 mm2, p = 0.068) and NSD (17.2 ± 11.4 vs 15.7 ± 10.7 mm2, p = 0.033). MCI demonstrated better defined lesions (NSD, PED, RPE atrophy) and more number of eyes with PED and pachyvessels in comparison to FAF.Both investigations had a 100% sensitivity in detecting NSD and 100% specificity for sub retinal deposits. This study demonstrates the ability of MCI to quantitatively and qualitatively define various clinical features in CSCR and the advantages it holds over FAF. MCI can hence be considered as a useful imaging modality in documenting and monitoring various structural changes in eyes with CSCR.
format	article
author	Vishal Govindahari Sumit Randhir Singh Bindu Rajesh Roberto Gallego-Pinazo Rosa Dolz Marco Dhanya V. Nair Unni Nair Jay Chhablani
author_facet	Vishal Govindahari Sumit Randhir Singh Bindu Rajesh Roberto Gallego-Pinazo Rosa Dolz Marco Dhanya V. Nair Unni Nair Jay Chhablani
author_sort	Vishal Govindahari
title	Multicolor imaging in central serous chorioretinopathy – a quantitative and qualitative comparison with fundus autofluorescence
title_short	Multicolor imaging in central serous chorioretinopathy – a quantitative and qualitative comparison with fundus autofluorescence
title_full	Multicolor imaging in central serous chorioretinopathy – a quantitative and qualitative comparison with fundus autofluorescence
title_fullStr	Multicolor imaging in central serous chorioretinopathy – a quantitative and qualitative comparison with fundus autofluorescence
title_full_unstemmed	Multicolor imaging in central serous chorioretinopathy – a quantitative and qualitative comparison with fundus autofluorescence
title_sort	multicolor imaging in central serous chorioretinopathy – a quantitative and qualitative comparison with fundus autofluorescence
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1341c2ce7b144b6793ba223c69e49deb
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Multicolor imaging in central serous chorioretinopathy – a quantitative and qualitative comparison with fundus autofluorescence

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