Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis

When grown in the lab, Mycobacterium tuberculosis can form pellicle biofilms. Here, Trivedi et al. show that thiol reductive stress (induced by dithiothreitol) triggers rapid formation of thicker biofilms containing cellulose as well as antibiotic-tolerant, metabolically active bacteria.

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Detalles Bibliográficos
Autores principales: Abhishek Trivedi, Parminder Singh Mavi, Deepak Bhatt, Ashwani Kumar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/1343f01915784f148e9099618582fc79
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Sumario:When grown in the lab, Mycobacterium tuberculosis can form pellicle biofilms. Here, Trivedi et al. show that thiol reductive stress (induced by dithiothreitol) triggers rapid formation of thicker biofilms containing cellulose as well as antibiotic-tolerant, metabolically active bacteria.