Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis
When grown in the lab, Mycobacterium tuberculosis can form pellicle biofilms. Here, Trivedi et al. show that thiol reductive stress (induced by dithiothreitol) triggers rapid formation of thicker biofilms containing cellulose as well as antibiotic-tolerant, metabolically active bacteria.
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Nature Portfolio
2016
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oai:doaj.org-article:1343f01915784f148e9099618582fc792021-12-02T15:34:08ZThiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis10.1038/ncomms113922041-1723https://doaj.org/article/1343f01915784f148e9099618582fc792016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11392https://doaj.org/toc/2041-1723When grown in the lab, Mycobacterium tuberculosis can form pellicle biofilms. Here, Trivedi et al. show that thiol reductive stress (induced by dithiothreitol) triggers rapid formation of thicker biofilms containing cellulose as well as antibiotic-tolerant, metabolically active bacteria.Abhishek TrivediParminder Singh MaviDeepak BhattAshwani KumarNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
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Science Q Abhishek Trivedi Parminder Singh Mavi Deepak Bhatt Ashwani Kumar Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis |
description |
When grown in the lab, Mycobacterium tuberculosis can form pellicle biofilms. Here, Trivedi et al. show that thiol reductive stress (induced by dithiothreitol) triggers rapid formation of thicker biofilms containing cellulose as well as antibiotic-tolerant, metabolically active bacteria. |
format |
article |
author |
Abhishek Trivedi Parminder Singh Mavi Deepak Bhatt Ashwani Kumar |
author_facet |
Abhishek Trivedi Parminder Singh Mavi Deepak Bhatt Ashwani Kumar |
author_sort |
Abhishek Trivedi |
title |
Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis |
title_short |
Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis |
title_full |
Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis |
title_fullStr |
Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis |
title_full_unstemmed |
Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis |
title_sort |
thiol reductive stress induces cellulose-anchored biofilm formation in mycobacterium tuberculosis |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/1343f01915784f148e9099618582fc79 |
work_keys_str_mv |
AT abhishektrivedi thiolreductivestressinducescelluloseanchoredbiofilmformationinmycobacteriumtuberculosis AT parmindersinghmavi thiolreductivestressinducescelluloseanchoredbiofilmformationinmycobacteriumtuberculosis AT deepakbhatt thiolreductivestressinducescelluloseanchoredbiofilmformationinmycobacteriumtuberculosis AT ashwanikumar thiolreductivestressinducescelluloseanchoredbiofilmformationinmycobacteriumtuberculosis |
_version_ |
1718386884734877696 |