Validating the Dosimetric Parameters of INTRABEAM Intraoperative Radiotherapy Machine

BACKGROUND AND OBJECTIVE: One of the methods for treating breast cancer is radiotherapy using low-kV X-rays in which a dedicated device called INTRABEAM is used along with a few spherical applicators for breast radiation. Due to the single-session nature of this treatment, evaluating the accuracy of...

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Autores principales:	HR Baghani, Zh Ghorbani, ME Akbari
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2019
Materias:	breast cancer intraoperative radiotherapy low-kv x-rays monte carlo simulation dosimetry Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/13453f9c79964b5bb75e096d92bb1764
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spelling	oai:doaj.org-article:13453f9c79964b5bb75e096d92bb17642021-11-10T08:30:36ZValidating the Dosimetric Parameters of INTRABEAM Intraoperative Radiotherapy Machine1561-41072251-7170https://doaj.org/article/13453f9c79964b5bb75e096d92bb17642019-12-01T00:00:00Zhttp://jbums.org/article-1-8324-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: One of the methods for treating breast cancer is radiotherapy using low-kV X-rays in which a dedicated device called INTRABEAM is used along with a few spherical applicators for breast radiation. Due to the single-session nature of this treatment, evaluating the accuracy of the device used for treatment is essential. The aim of this study was to evaluate the dosimetric parameters of the INTRABEAM system with spherical applicators and validate the reported results for clinical use in intraoperative radiotherapy for breast tumors. METHODS: In this study, dosimetric parameters including percentage depth dose curve (PDD), transfer function (TF) and anisotropy were determined by MCNPX Monte Carlo Simulation Tool and practical dosimetry was done by Gafchromic EBT2 film. The results were quantitatively compared with the results reported by manufacturer of the device (Carl Zeiss) to evaluate the accuracy of the reported data for this treatment system. FINDINGS: The mean difference when comparing PDD curves was 1.7% and the mean difference between the compared TF values was about 2%. The anisotropy values obtained by Monte Carlo Simulation and Gafchromic EBT2 film were also within the range recommended by the manufacturer. CONCLUSION: Based on the results, it can be concluded that the dosimetric parameters reported by the manufacturer for spherical applicators of the INTRABEAM system are valid for designing the treatment and radiotherapy for patients.HR BaghaniZh GhorbaniME AkbariBabol University of Medical Sciencesarticlebreast cancerintraoperative radiotherapylow-kv x-raysmonte carlo simulationdosimetryMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 21, Iss 1, Pp 174-180 (2019)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	breast cancer intraoperative radiotherapy low-kv x-rays monte carlo simulation dosimetry Medicine R Medicine (General) R5-920
spellingShingle	breast cancer intraoperative radiotherapy low-kv x-rays monte carlo simulation dosimetry Medicine R Medicine (General) R5-920 HR Baghani Zh Ghorbani ME Akbari Validating the Dosimetric Parameters of INTRABEAM Intraoperative Radiotherapy Machine
description	BACKGROUND AND OBJECTIVE: One of the methods for treating breast cancer is radiotherapy using low-kV X-rays in which a dedicated device called INTRABEAM is used along with a few spherical applicators for breast radiation. Due to the single-session nature of this treatment, evaluating the accuracy of the device used for treatment is essential. The aim of this study was to evaluate the dosimetric parameters of the INTRABEAM system with spherical applicators and validate the reported results for clinical use in intraoperative radiotherapy for breast tumors. METHODS: In this study, dosimetric parameters including percentage depth dose curve (PDD), transfer function (TF) and anisotropy were determined by MCNPX Monte Carlo Simulation Tool and practical dosimetry was done by Gafchromic EBT2 film. The results were quantitatively compared with the results reported by manufacturer of the device (Carl Zeiss) to evaluate the accuracy of the reported data for this treatment system. FINDINGS: The mean difference when comparing PDD curves was 1.7% and the mean difference between the compared TF values was about 2%. The anisotropy values obtained by Monte Carlo Simulation and Gafchromic EBT2 film were also within the range recommended by the manufacturer. CONCLUSION: Based on the results, it can be concluded that the dosimetric parameters reported by the manufacturer for spherical applicators of the INTRABEAM system are valid for designing the treatment and radiotherapy for patients.
format	article
author	HR Baghani Zh Ghorbani ME Akbari
author_facet	HR Baghani Zh Ghorbani ME Akbari
author_sort	HR Baghani
title	Validating the Dosimetric Parameters of INTRABEAM Intraoperative Radiotherapy Machine
title_short	Validating the Dosimetric Parameters of INTRABEAM Intraoperative Radiotherapy Machine
title_full	Validating the Dosimetric Parameters of INTRABEAM Intraoperative Radiotherapy Machine
title_fullStr	Validating the Dosimetric Parameters of INTRABEAM Intraoperative Radiotherapy Machine
title_full_unstemmed	Validating the Dosimetric Parameters of INTRABEAM Intraoperative Radiotherapy Machine
title_sort	validating the dosimetric parameters of intrabeam intraoperative radiotherapy machine
publisher	Babol University of Medical Sciences
publishDate	2019
url	https://doaj.org/article/13453f9c79964b5bb75e096d92bb1764
work_keys_str_mv	AT hrbaghani validatingthedosimetricparametersofintrabeamintraoperativeradiotherapymachine AT zhghorbani validatingthedosimetricparametersofintrabeamintraoperativeradiotherapymachine AT meakbari validatingthedosimetricparametersofintrabeamintraoperativeradiotherapymachine
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Validating the Dosimetric Parameters of INTRABEAM Intraoperative Radiotherapy Machine

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