The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes
Ying Yao,* Yiteng Zang,* Jing Qu, Meng Tang, Ting Zhang Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, People’s Republic of China*These authors contributed equally to this workCorrespondence: T...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2019
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| Acceso en línea: | https://doaj.org/article/1348389d870e45488b2c55df085f7867 |
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| Sumario: | Ying Yao,* Yiteng Zang,* Jing Qu, Meng Tang, Ting Zhang Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ting ZhangKey Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, People’s Republic of ChinaTel +86-25-83272566Fax +86-25-83272566Email zhangting@seu.edu.cnAbstract: Metallic nanoparticles (MNPs) are new engineering materials with broad prospects for biomedical applications; thus, their biosafety has drawn great concern. The liver is the main detoxification organ of vertebrates. However, many issues concerning the interactions between MNPs and biological systems (cells and tissues) are unclear, particularly the toxic effects of MNPs on hepatocytes and other liver cells. Numerous researchers have shown that some MNPs can induce decreased cell survival rate, production of reactive oxygen species (ROS), mitochondrial damage, DNA strand breaks, and even autophagy, pyroptosis, apoptosis, or other forms of cell death. Our review focuses on the recent researches on the liver toxicity of MNPs and its mechanisms at cellular and subcellular levels to provide a scientific basis for the subsequent hepatotoxicity studies of MNPs.Keywords: metallic nanoparticles, hepatotoxicity, subcellular injury, dysfunctions, toxicity outcome |
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