The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes

Ying Yao,* Yiteng Zang,* Jing Qu, Meng Tang, Ting Zhang Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, People’s Republic of China*These authors contributed equally to this workCorrespondence: T...

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Autores principales:	Yao Y, Zang Y, Qu J, Tang M, Zhang T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	metallic nanoparticles hepatotoxicity subcellular injury dysfunctions toxicity outcome Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1348389d870e45488b2c55df085f7867
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spelling	oai:doaj.org-article:1348389d870e45488b2c55df085f78672021-12-02T09:04:19ZThe Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes1178-2013https://doaj.org/article/1348389d870e45488b2c55df085f78672019-11-01T00:00:00Zhttps://www.dovepress.com/the-toxicity-of-metallic-nanoparticles-on-liver-the-subcellular-damage-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ying Yao,* Yiteng Zang,* Jing Qu, Meng Tang, Ting Zhang Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ting ZhangKey Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, People’s Republic of ChinaTel +86-25-83272566Fax +86-25-83272566Email zhangting@seu.edu.cnAbstract: Metallic nanoparticles (MNPs) are new engineering materials with broad prospects for biomedical applications; thus, their biosafety has drawn great concern. The liver is the main detoxification organ of vertebrates. However, many issues concerning the interactions between MNPs and biological systems (cells and tissues) are unclear, particularly the toxic effects of MNPs on hepatocytes and other liver cells. Numerous researchers have shown that some MNPs can induce decreased cell survival rate, production of reactive oxygen species (ROS), mitochondrial damage, DNA strand breaks, and even autophagy, pyroptosis, apoptosis, or other forms of cell death. Our review focuses on the recent researches on the liver toxicity of MNPs and its mechanisms at cellular and subcellular levels to provide a scientific basis for the subsequent hepatotoxicity studies of MNPs.Keywords: metallic nanoparticles, hepatotoxicity, subcellular injury, dysfunctions, toxicity outcomeYao YZang YQu JTang MZhang TDove Medical Pressarticlemetallic nanoparticleshepatotoxicitysubcellular injurydysfunctionstoxicity outcomeMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 8787-8804 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	metallic nanoparticles hepatotoxicity subcellular injury dysfunctions toxicity outcome Medicine (General) R5-920
spellingShingle	metallic nanoparticles hepatotoxicity subcellular injury dysfunctions toxicity outcome Medicine (General) R5-920 Yao Y Zang Y Qu J Tang M Zhang T The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes
description	Ying Yao,* Yiteng Zang,* Jing Qu, Meng Tang, Ting Zhang Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ting ZhangKey Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing 210009, People’s Republic of ChinaTel +86-25-83272566Fax +86-25-83272566Email zhangting@seu.edu.cnAbstract: Metallic nanoparticles (MNPs) are new engineering materials with broad prospects for biomedical applications; thus, their biosafety has drawn great concern. The liver is the main detoxification organ of vertebrates. However, many issues concerning the interactions between MNPs and biological systems (cells and tissues) are unclear, particularly the toxic effects of MNPs on hepatocytes and other liver cells. Numerous researchers have shown that some MNPs can induce decreased cell survival rate, production of reactive oxygen species (ROS), mitochondrial damage, DNA strand breaks, and even autophagy, pyroptosis, apoptosis, or other forms of cell death. Our review focuses on the recent researches on the liver toxicity of MNPs and its mechanisms at cellular and subcellular levels to provide a scientific basis for the subsequent hepatotoxicity studies of MNPs.Keywords: metallic nanoparticles, hepatotoxicity, subcellular injury, dysfunctions, toxicity outcome
format	article
author	Yao Y Zang Y Qu J Tang M Zhang T
author_facet	Yao Y Zang Y Qu J Tang M Zhang T
author_sort	Yao Y
title	The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes
title_short	The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes
title_full	The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes
title_fullStr	The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes
title_full_unstemmed	The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes
title_sort	toxicity of metallic nanoparticles on liver: the subcellular damages, mechanisms, and outcomes
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/1348389d870e45488b2c55df085f7867
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The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes

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