Etiology of maculopapular rash in measles and rubella suspected patients from Belarus.

As a result of successful implementation of the measles/rubella elimination program, the etiology of more and more double negative cases remains elusive. The present study determined the role of different viruses as causative agents in measles or rubella suspected cases in Belarus. A total of 856 se...

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Autores principales:	Marina A Yermalovich, Galina V Semeiko, Elena O Samoilovich, Ekaterina Y Svirchevskaya, Claude P Muller, Judith M Hübschen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13489b3b47964f42bc5267bb5792dd0f
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spelling	oai:doaj.org-article:13489b3b47964f42bc5267bb5792dd0f2021-11-25T05:55:03ZEtiology of maculopapular rash in measles and rubella suspected patients from Belarus.1932-620310.1371/journal.pone.0111541https://doaj.org/article/13489b3b47964f42bc5267bb5792dd0f2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0111541https://doaj.org/toc/1932-6203As a result of successful implementation of the measles/rubella elimination program, the etiology of more and more double negative cases remains elusive. The present study determined the role of different viruses as causative agents in measles or rubella suspected cases in Belarus. A total of 856 sera sent to the WHO National Laboratory between 2009 and 2011 were tested for specific IgM antibodies to measles virus (MV), rubella virus (RV) and human parvovirus B19 (B19V). The negatives were further investigated for antibodies to enterovirus (EV) and adenovirus (AdV). Children of up to 3 years were tested for IgM antibodies to human herpesvirus 6 (HHV6). A viral etiology was identified in 451 (52.7%) cases, with 6.1% of the samples being positive for MV; 2.6% for RV; 26.2% for B19V; 9.7% for EV; 4.6% for AdV; and 3.6% for HHV6. Almost all measles and rubella cases occurred during limited outbreaks in 2011 and nearly all patients were at least 15 years old. B19V, EV and AdV infections were prevalent both in children and adults and were found throughout the 3 years. B19V occurred mainly in 3-10 years old children and 20-29 years old adults. EV infection was most common in children up to 6 years of age and AdV was confirmed mainly in 3-6 years old children. HHV6 infection was mostly detected in 6-11 months old infants. Laboratory investigation of measles/rubella suspected cases also for B19V, EV, AdV and HHV6 allows diagnosing more than half of all cases, thus strengthening rash/fever disease surveillance in Belarus.Marina A YermalovichGalina V SemeikoElena O SamoilovichEkaterina Y SvirchevskayaClaude P MullerJudith M HübschenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e111541 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marina A Yermalovich Galina V Semeiko Elena O Samoilovich Ekaterina Y Svirchevskaya Claude P Muller Judith M Hübschen Etiology of maculopapular rash in measles and rubella suspected patients from Belarus.
description	As a result of successful implementation of the measles/rubella elimination program, the etiology of more and more double negative cases remains elusive. The present study determined the role of different viruses as causative agents in measles or rubella suspected cases in Belarus. A total of 856 sera sent to the WHO National Laboratory between 2009 and 2011 were tested for specific IgM antibodies to measles virus (MV), rubella virus (RV) and human parvovirus B19 (B19V). The negatives were further investigated for antibodies to enterovirus (EV) and adenovirus (AdV). Children of up to 3 years were tested for IgM antibodies to human herpesvirus 6 (HHV6). A viral etiology was identified in 451 (52.7%) cases, with 6.1% of the samples being positive for MV; 2.6% for RV; 26.2% for B19V; 9.7% for EV; 4.6% for AdV; and 3.6% for HHV6. Almost all measles and rubella cases occurred during limited outbreaks in 2011 and nearly all patients were at least 15 years old. B19V, EV and AdV infections were prevalent both in children and adults and were found throughout the 3 years. B19V occurred mainly in 3-10 years old children and 20-29 years old adults. EV infection was most common in children up to 6 years of age and AdV was confirmed mainly in 3-6 years old children. HHV6 infection was mostly detected in 6-11 months old infants. Laboratory investigation of measles/rubella suspected cases also for B19V, EV, AdV and HHV6 allows diagnosing more than half of all cases, thus strengthening rash/fever disease surveillance in Belarus.
format	article
author	Marina A Yermalovich Galina V Semeiko Elena O Samoilovich Ekaterina Y Svirchevskaya Claude P Muller Judith M Hübschen
author_facet	Marina A Yermalovich Galina V Semeiko Elena O Samoilovich Ekaterina Y Svirchevskaya Claude P Muller Judith M Hübschen
author_sort	Marina A Yermalovich
title	Etiology of maculopapular rash in measles and rubella suspected patients from Belarus.
title_short	Etiology of maculopapular rash in measles and rubella suspected patients from Belarus.
title_full	Etiology of maculopapular rash in measles and rubella suspected patients from Belarus.
title_fullStr	Etiology of maculopapular rash in measles and rubella suspected patients from Belarus.
title_full_unstemmed	Etiology of maculopapular rash in measles and rubella suspected patients from Belarus.
title_sort	etiology of maculopapular rash in measles and rubella suspected patients from belarus.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/13489b3b47964f42bc5267bb5792dd0f
work_keys_str_mv	AT marinaayermalovich etiologyofmaculopapularrashinmeaslesandrubellasuspectedpatientsfrombelarus AT galinavsemeiko etiologyofmaculopapularrashinmeaslesandrubellasuspectedpatientsfrombelarus AT elenaosamoilovich etiologyofmaculopapularrashinmeaslesandrubellasuspectedpatientsfrombelarus AT ekaterinaysvirchevskaya etiologyofmaculopapularrashinmeaslesandrubellasuspectedpatientsfrombelarus AT claudepmuller etiologyofmaculopapularrashinmeaslesandrubellasuspectedpatientsfrombelarus AT judithmhubschen etiologyofmaculopapularrashinmeaslesandrubellasuspectedpatientsfrombelarus
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Etiology of maculopapular rash in measles and rubella suspected patients from Belarus.

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