The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression

ELL2 was recently discovered as a susceptibility gene for multiple myeloma (MM). Here, they show that the MM risk allele lowers ELL2 expression in plasma cells, that it also upregulates gene sets related to ribosome biogenesis, and that one of the linked variants reduces binding of MAFF/G/K family t...

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Autores principales:	Mina Ali, Ram Ajore, Anna-Karin Wihlborg, Abhishek Niroula, Bhairavi Swaminathan, Ellinor Johnsson, Owen W Stephens, Gareth Morgan, Tobias Meissner, Ingemar Turesson, Hartmut Goldschmidt, Ulf-Henrik Mellqvist, Urban Gullberg, Markus Hansson, Kari Hemminki, Hareth Nahi, Anders Waage, Niels Weinhold, Björn Nilsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13489db4fa564fee8966c2324c237725
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spelling	oai:doaj.org-article:13489db4fa564fee8966c2324c2377252021-12-02T14:39:04ZThe multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression10.1038/s41467-018-04082-22041-1723https://doaj.org/article/13489db4fa564fee8966c2324c2377252018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04082-2https://doaj.org/toc/2041-1723ELL2 was recently discovered as a susceptibility gene for multiple myeloma (MM). Here, they show that the MM risk allele lowers ELL2 expression in plasma cells, that it also upregulates gene sets related to ribosome biogenesis, and that one of the linked variants reduces binding of MAFF/G/K family transcription factors.Mina AliRam AjoreAnna-Karin WihlborgAbhishek NiroulaBhairavi SwaminathanEllinor JohnssonOwen W StephensGareth MorganTobias MeissnerIngemar TuressonHartmut GoldschmidtUlf-Henrik MellqvistUrban GullbergMarkus HanssonKari HemminkiHareth NahiAnders WaageNiels WeinholdBjörn NilssonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mina Ali Ram Ajore Anna-Karin Wihlborg Abhishek Niroula Bhairavi Swaminathan Ellinor Johnsson Owen W Stephens Gareth Morgan Tobias Meissner Ingemar Turesson Hartmut Goldschmidt Ulf-Henrik Mellqvist Urban Gullberg Markus Hansson Kari Hemminki Hareth Nahi Anders Waage Niels Weinhold Björn Nilsson The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
description	ELL2 was recently discovered as a susceptibility gene for multiple myeloma (MM). Here, they show that the MM risk allele lowers ELL2 expression in plasma cells, that it also upregulates gene sets related to ribosome biogenesis, and that one of the linked variants reduces binding of MAFF/G/K family transcription factors.
format	article
author	Mina Ali Ram Ajore Anna-Karin Wihlborg Abhishek Niroula Bhairavi Swaminathan Ellinor Johnsson Owen W Stephens Gareth Morgan Tobias Meissner Ingemar Turesson Hartmut Goldschmidt Ulf-Henrik Mellqvist Urban Gullberg Markus Hansson Kari Hemminki Hareth Nahi Anders Waage Niels Weinhold Björn Nilsson
author_facet	Mina Ali Ram Ajore Anna-Karin Wihlborg Abhishek Niroula Bhairavi Swaminathan Ellinor Johnsson Owen W Stephens Gareth Morgan Tobias Meissner Ingemar Turesson Hartmut Goldschmidt Ulf-Henrik Mellqvist Urban Gullberg Markus Hansson Kari Hemminki Hareth Nahi Anders Waage Niels Weinhold Björn Nilsson
author_sort	Mina Ali
title	The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
title_short	The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
title_full	The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
title_fullStr	The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
title_full_unstemmed	The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
title_sort	multiple myeloma risk allele at 5q15 lowers ell2 expression and increases ribosomal gene expression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/13489db4fa564fee8966c2324c237725
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The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression

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