The landscape of alternative polyadenylation in single cells of the developing mouse embryo

Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are regulated across cell types and developmental time....

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Autores principales: Vikram Agarwal, Sereno Lopez-Darwin, David R. Kelley, Jay Shendure
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/134bcf57b93d4e3b8d28f9f70ad6e1af
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Sumario:Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are regulated across cell types and developmental time.