The landscape of alternative polyadenylation in single cells of the developing mouse embryo

Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are regulated across cell types and developmental time....

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Autores principales:	Vikram Agarwal, Sereno Lopez-Darwin, David R. Kelley, Jay Shendure
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/134bcf57b93d4e3b8d28f9f70ad6e1af
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spelling	oai:doaj.org-article:134bcf57b93d4e3b8d28f9f70ad6e1af2021-12-02T15:09:09ZThe landscape of alternative polyadenylation in single cells of the developing mouse embryo10.1038/s41467-021-25388-82041-1723https://doaj.org/article/134bcf57b93d4e3b8d28f9f70ad6e1af2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25388-8https://doaj.org/toc/2041-1723Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are regulated across cell types and developmental time.Vikram AgarwalSereno Lopez-DarwinDavid R. KelleyJay ShendureNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vikram Agarwal Sereno Lopez-Darwin David R. Kelley Jay Shendure The landscape of alternative polyadenylation in single cells of the developing mouse embryo
description	Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are regulated across cell types and developmental time.
format	article
author	Vikram Agarwal Sereno Lopez-Darwin David R. Kelley Jay Shendure
author_facet	Vikram Agarwal Sereno Lopez-Darwin David R. Kelley Jay Shendure
author_sort	Vikram Agarwal
title	The landscape of alternative polyadenylation in single cells of the developing mouse embryo
title_short	The landscape of alternative polyadenylation in single cells of the developing mouse embryo
title_full	The landscape of alternative polyadenylation in single cells of the developing mouse embryo
title_fullStr	The landscape of alternative polyadenylation in single cells of the developing mouse embryo
title_full_unstemmed	The landscape of alternative polyadenylation in single cells of the developing mouse embryo
title_sort	landscape of alternative polyadenylation in single cells of the developing mouse embryo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/134bcf57b93d4e3b8d28f9f70ad6e1af
work_keys_str_mv	AT vikramagarwal thelandscapeofalternativepolyadenylationinsinglecellsofthedevelopingmouseembryo AT serenolopezdarwin thelandscapeofalternativepolyadenylationinsinglecellsofthedevelopingmouseembryo AT davidrkelley thelandscapeofalternativepolyadenylationinsinglecellsofthedevelopingmouseembryo AT jayshendure thelandscapeofalternativepolyadenylationinsinglecellsofthedevelopingmouseembryo AT vikramagarwal landscapeofalternativepolyadenylationinsinglecellsofthedevelopingmouseembryo AT serenolopezdarwin landscapeofalternativepolyadenylationinsinglecellsofthedevelopingmouseembryo AT davidrkelley landscapeofalternativepolyadenylationinsinglecellsofthedevelopingmouseembryo AT jayshendure landscapeofalternativepolyadenylationinsinglecellsofthedevelopingmouseembryo
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The landscape of alternative polyadenylation in single cells of the developing mouse embryo

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