Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: From Epidemiology to Diagnostic Approach

Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause of liver morbidity worldwide and, as such, represents the pathogenic background for the increasing incidence of hepatocellular carcinoma (HCC). The annual incidence of NAFLD-related HCC is expected to increase by 45–130% by 2030...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ivica Grgurevic, Tonci Bozin, Mislav Mikus, Michal Kukla, James O’Beirne
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocellular carcinoma non-alcoholic fatty liver disease metabolic syndrome diabetes mellitus screening programs biomarkers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1350f22a4dbf4015b811dec5b0c2b829
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1350f22a4dbf4015b811dec5b0c2b829
record_format	dspace
spelling	oai:doaj.org-article:1350f22a4dbf4015b811dec5b0c2b8292021-11-25T17:04:39ZHepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: From Epidemiology to Diagnostic Approach10.3390/cancers132258442072-6694https://doaj.org/article/1350f22a4dbf4015b811dec5b0c2b8292021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5844https://doaj.org/toc/2072-6694Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause of liver morbidity worldwide and, as such, represents the pathogenic background for the increasing incidence of hepatocellular carcinoma (HCC). The annual incidence of NAFLD-related HCC is expected to increase by 45–130% by 2030. Diabetes mellitus is the most important risk factor for HCC development in NAFLD, with the risk further increased when associated with other metabolic traits, such as obesity, arterial hypertension and dyslipidemia. The highest risk of HCC exists in patients with advanced fibrosis or cirrhosis, although 20–50% of HCC cases arise in NAFLD patients with an absence of cirrhosis. This calls for further investigation of the pathogenic mechanisms that are involved in hepatocarcinogenesis, including genetics, metabolomics, the influence of the gut microbiota and immunological responses. Early identification of patients with or at risk of NAFLD is of utmost importance to improve outcomes. As NAFLD is highly prevalent in the community, the identification of cases should rely upon simple demographic and clinical characteristics. Once identified, these patients should then be evaluated for the presence of advanced fibrosis or cirrhosis and subsequently enter HCC surveillance programs if appropriate. A significant problem is the early recognition of non-cirrhotic NAFLD patients who will develop HCC, where new biomarkers and scores are potential solutions to tackle this issue.Ivica GrgurevicTonci BozinMislav MikusMichal KuklaJames O’BeirneMDPI AGarticlehepatocellular carcinomanon-alcoholic fatty liver diseasemetabolic syndromediabetes mellitusscreening programsbiomarkersNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5844, p 5844 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma non-alcoholic fatty liver disease metabolic syndrome diabetes mellitus screening programs biomarkers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma non-alcoholic fatty liver disease metabolic syndrome diabetes mellitus screening programs biomarkers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ivica Grgurevic Tonci Bozin Mislav Mikus Michal Kukla James O’Beirne Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: From Epidemiology to Diagnostic Approach
description	Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause of liver morbidity worldwide and, as such, represents the pathogenic background for the increasing incidence of hepatocellular carcinoma (HCC). The annual incidence of NAFLD-related HCC is expected to increase by 45–130% by 2030. Diabetes mellitus is the most important risk factor for HCC development in NAFLD, with the risk further increased when associated with other metabolic traits, such as obesity, arterial hypertension and dyslipidemia. The highest risk of HCC exists in patients with advanced fibrosis or cirrhosis, although 20–50% of HCC cases arise in NAFLD patients with an absence of cirrhosis. This calls for further investigation of the pathogenic mechanisms that are involved in hepatocarcinogenesis, including genetics, metabolomics, the influence of the gut microbiota and immunological responses. Early identification of patients with or at risk of NAFLD is of utmost importance to improve outcomes. As NAFLD is highly prevalent in the community, the identification of cases should rely upon simple demographic and clinical characteristics. Once identified, these patients should then be evaluated for the presence of advanced fibrosis or cirrhosis and subsequently enter HCC surveillance programs if appropriate. A significant problem is the early recognition of non-cirrhotic NAFLD patients who will develop HCC, where new biomarkers and scores are potential solutions to tackle this issue.
format	article
author	Ivica Grgurevic Tonci Bozin Mislav Mikus Michal Kukla James O’Beirne
author_facet	Ivica Grgurevic Tonci Bozin Mislav Mikus Michal Kukla James O’Beirne
author_sort	Ivica Grgurevic
title	Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: From Epidemiology to Diagnostic Approach
title_short	Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: From Epidemiology to Diagnostic Approach
title_full	Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: From Epidemiology to Diagnostic Approach
title_fullStr	Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: From Epidemiology to Diagnostic Approach
title_full_unstemmed	Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: From Epidemiology to Diagnostic Approach
title_sort	hepatocellular carcinoma in non-alcoholic fatty liver disease: from epidemiology to diagnostic approach
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1350f22a4dbf4015b811dec5b0c2b829
work_keys_str_mv	AT ivicagrgurevic hepatocellularcarcinomainnonalcoholicfattyliverdiseasefromepidemiologytodiagnosticapproach AT toncibozin hepatocellularcarcinomainnonalcoholicfattyliverdiseasefromepidemiologytodiagnosticapproach AT mislavmikus hepatocellularcarcinomainnonalcoholicfattyliverdiseasefromepidemiologytodiagnosticapproach AT michalkukla hepatocellularcarcinomainnonalcoholicfattyliverdiseasefromepidemiologytodiagnosticapproach AT jamesobeirne hepatocellularcarcinomainnonalcoholicfattyliverdiseasefromepidemiologytodiagnosticapproach
_version_	1718412696189140992

Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: From Epidemiology to Diagnostic Approach

Ejemplares similares