Radiographic and Histomorphometric Evaluation of Biomaterials Used for Lateral Sinus Augmentation: A Systematic Review on the Effect of Residual Bone Height and Vertical Graft Size on New Bone Formation and Graft Shrinkage

The aim of the present systematic review was to investigate the effect of residual bone height (RBH) and vertical bone gain on new bone formation (NBF) and graft shrinkage after lateral sinus lifts using different biomaterials. Methods: An electronic search was conducted on three databases to identi...

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Autores principales:	Paolo Pesce, Maria Menini, Luigi Canullo, Shahnawaz Khijmatgar, Laura Modenese, Gianmarco Gallifante, Massimo Del Fabbro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sinus lift bone regeneration biomaterials grafts Medicine R
Acceso en línea:	https://doaj.org/article/135159f5c1154a9f89e2559921670665
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spelling	oai:doaj.org-article:135159f5c1154a9f89e25599216706652021-11-11T17:37:40ZRadiographic and Histomorphometric Evaluation of Biomaterials Used for Lateral Sinus Augmentation: A Systematic Review on the Effect of Residual Bone Height and Vertical Graft Size on New Bone Formation and Graft Shrinkage10.3390/jcm102149962077-0383https://doaj.org/article/135159f5c1154a9f89e25599216706652021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4996https://doaj.org/toc/2077-0383The aim of the present systematic review was to investigate the effect of residual bone height (RBH) and vertical bone gain on new bone formation (NBF) and graft shrinkage after lateral sinus lifts using different biomaterials. Methods: An electronic search was conducted on three databases to identify randomized controlled trials (RCTs) published until January 2021 with at least one follow-up at 6 months and at least five patients treated, comparing biomaterials used for maxillary sinus augmentation with a lateral approach. Graft volumetric changes, RBH, vertical bone gain, implant failure, and post-operative complications were evaluated. The risk of bias was assessed using the Cochrane tool. Results: We used 4010 identified studies, of which 21 were RCTs. Overall, 412 patients and 533 sinuses were evaluated. Only three publications had an overall low risk of bias. After 6 months, xenograft (XG) showed the least volume reduction (7.30 ± 15.49%), while autogenous graft (AU) was the most reabsorbed (41.71 ± 12.63%). NBF appeared to not be directly correlated with RBH; on the contrary, the overall linear regression analysis showed that NBF significantly decreased by 1.6% for each mm of postoperative vertical graft gain. This finding suggests that the greater the augmentation, the lower the NBF. A similar tendency, with a regression coefficient even higher than the overall one, was also observed with alloplast (AP) and XG. Conclusions: The present results suggested that NBF was essentially independent of preoperative bone height. On the contrary, the smaller the volume was of the graft placed, the higher the amount of new bone formed, and the smaller the graft shrinkage was. Minimizing the augmentation volume might be beneficial to graft healing and stability especially when using AP and XG.Paolo PesceMaria MeniniLuigi CanulloShahnawaz KhijmatgarLaura ModeneseGianmarco GallifanteMassimo Del FabbroMDPI AGarticlesinus liftbone regenerationbiomaterialsgraftsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4996, p 4996 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sinus lift bone regeneration biomaterials grafts Medicine R
spellingShingle	sinus lift bone regeneration biomaterials grafts Medicine R Paolo Pesce Maria Menini Luigi Canullo Shahnawaz Khijmatgar Laura Modenese Gianmarco Gallifante Massimo Del Fabbro Radiographic and Histomorphometric Evaluation of Biomaterials Used for Lateral Sinus Augmentation: A Systematic Review on the Effect of Residual Bone Height and Vertical Graft Size on New Bone Formation and Graft Shrinkage
description	The aim of the present systematic review was to investigate the effect of residual bone height (RBH) and vertical bone gain on new bone formation (NBF) and graft shrinkage after lateral sinus lifts using different biomaterials. Methods: An electronic search was conducted on three databases to identify randomized controlled trials (RCTs) published until January 2021 with at least one follow-up at 6 months and at least five patients treated, comparing biomaterials used for maxillary sinus augmentation with a lateral approach. Graft volumetric changes, RBH, vertical bone gain, implant failure, and post-operative complications were evaluated. The risk of bias was assessed using the Cochrane tool. Results: We used 4010 identified studies, of which 21 were RCTs. Overall, 412 patients and 533 sinuses were evaluated. Only three publications had an overall low risk of bias. After 6 months, xenograft (XG) showed the least volume reduction (7.30 ± 15.49%), while autogenous graft (AU) was the most reabsorbed (41.71 ± 12.63%). NBF appeared to not be directly correlated with RBH; on the contrary, the overall linear regression analysis showed that NBF significantly decreased by 1.6% for each mm of postoperative vertical graft gain. This finding suggests that the greater the augmentation, the lower the NBF. A similar tendency, with a regression coefficient even higher than the overall one, was also observed with alloplast (AP) and XG. Conclusions: The present results suggested that NBF was essentially independent of preoperative bone height. On the contrary, the smaller the volume was of the graft placed, the higher the amount of new bone formed, and the smaller the graft shrinkage was. Minimizing the augmentation volume might be beneficial to graft healing and stability especially when using AP and XG.
format	article
author	Paolo Pesce Maria Menini Luigi Canullo Shahnawaz Khijmatgar Laura Modenese Gianmarco Gallifante Massimo Del Fabbro
author_facet	Paolo Pesce Maria Menini Luigi Canullo Shahnawaz Khijmatgar Laura Modenese Gianmarco Gallifante Massimo Del Fabbro
author_sort	Paolo Pesce
title	Radiographic and Histomorphometric Evaluation of Biomaterials Used for Lateral Sinus Augmentation: A Systematic Review on the Effect of Residual Bone Height and Vertical Graft Size on New Bone Formation and Graft Shrinkage
title_short	Radiographic and Histomorphometric Evaluation of Biomaterials Used for Lateral Sinus Augmentation: A Systematic Review on the Effect of Residual Bone Height and Vertical Graft Size on New Bone Formation and Graft Shrinkage
title_full	Radiographic and Histomorphometric Evaluation of Biomaterials Used for Lateral Sinus Augmentation: A Systematic Review on the Effect of Residual Bone Height and Vertical Graft Size on New Bone Formation and Graft Shrinkage
title_fullStr	Radiographic and Histomorphometric Evaluation of Biomaterials Used for Lateral Sinus Augmentation: A Systematic Review on the Effect of Residual Bone Height and Vertical Graft Size on New Bone Formation and Graft Shrinkage
title_full_unstemmed	Radiographic and Histomorphometric Evaluation of Biomaterials Used for Lateral Sinus Augmentation: A Systematic Review on the Effect of Residual Bone Height and Vertical Graft Size on New Bone Formation and Graft Shrinkage
title_sort	radiographic and histomorphometric evaluation of biomaterials used for lateral sinus augmentation: a systematic review on the effect of residual bone height and vertical graft size on new bone formation and graft shrinkage
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/135159f5c1154a9f89e2559921670665
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Radiographic and Histomorphometric Evaluation of Biomaterials Used for Lateral Sinus Augmentation: A Systematic Review on the Effect of Residual Bone Height and Vertical Graft Size on New Bone Formation and Graft Shrinkage

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