Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis

Abstract This longitudinal study was designed to elucidate whether gut microbiota is associated with relapse and treatment response in ulcerative colitis (UC) patients. Fifty-one patients with UC were enrolled between 2012 and 2017, and followed up through 2020. Colon mucosal biopsy were obtained at...

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Autores principales:	Yuichiro Nishihara, Haruei Ogino, Masaru Tanaka, Eikichi Ihara, Keita Fukaura, Kei Nishioka, Takatoshi Chinen, Yoshimasa Tanaka, Jiro Nakayama, Dongchon Kang, Yoshihiro Ogawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1358905895eb46d3bb842e2fa402d545
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spelling	oai:doaj.org-article:1358905895eb46d3bb842e2fa402d5452021-12-02T16:10:37ZMucosa-associated gut microbiota reflects clinical course of ulcerative colitis10.1038/s41598-021-92870-02045-2322https://doaj.org/article/1358905895eb46d3bb842e2fa402d5452021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92870-0https://doaj.org/toc/2045-2322Abstract This longitudinal study was designed to elucidate whether gut microbiota is associated with relapse and treatment response in ulcerative colitis (UC) patients. Fifty-one patients with UC were enrolled between 2012 and 2017, and followed up through 2020. Colon mucosal biopsy were obtained at enrollment, and 16S ribosomal RNA sequencing was performed using extracted RNA. Of the 51 patients, 24 were in remission and 27 had active UC at enrollment. Of the 24 patients in remission, 17 maintained remission and 7 developed relapse during follow-up. The 7 patients with relapse showed lower diversity, with a lower proportion of Clostridiales (p = 0.0043), and a higher proportion of Bacteroides (p = 0.047) at enrollment than those without relapse. The 27 patients with active UC were classified into response (n = 6), refractory (n = 13), and non-response (n = 8) groups according to their treatment response in 6 months. The refractory and non-response groups showed lower diversity with a lower proportion of Prevotella (p = 0.048 and 0.043) at enrollment than the response group. This study is the first demonstration that reduced diversity and particular microbes are associated with the later clinical course of relapse events and treatment response in UC.Yuichiro NishiharaHaruei OginoMasaru TanakaEikichi IharaKeita FukauraKei NishiokaTakatoshi ChinenYoshimasa TanakaJiro NakayamaDongchon KangYoshihiro OgawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuichiro Nishihara Haruei Ogino Masaru Tanaka Eikichi Ihara Keita Fukaura Kei Nishioka Takatoshi Chinen Yoshimasa Tanaka Jiro Nakayama Dongchon Kang Yoshihiro Ogawa Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis
description	Abstract This longitudinal study was designed to elucidate whether gut microbiota is associated with relapse and treatment response in ulcerative colitis (UC) patients. Fifty-one patients with UC were enrolled between 2012 and 2017, and followed up through 2020. Colon mucosal biopsy were obtained at enrollment, and 16S ribosomal RNA sequencing was performed using extracted RNA. Of the 51 patients, 24 were in remission and 27 had active UC at enrollment. Of the 24 patients in remission, 17 maintained remission and 7 developed relapse during follow-up. The 7 patients with relapse showed lower diversity, with a lower proportion of Clostridiales (p = 0.0043), and a higher proportion of Bacteroides (p = 0.047) at enrollment than those without relapse. The 27 patients with active UC were classified into response (n = 6), refractory (n = 13), and non-response (n = 8) groups according to their treatment response in 6 months. The refractory and non-response groups showed lower diversity with a lower proportion of Prevotella (p = 0.048 and 0.043) at enrollment than the response group. This study is the first demonstration that reduced diversity and particular microbes are associated with the later clinical course of relapse events and treatment response in UC.
format	article
author	Yuichiro Nishihara Haruei Ogino Masaru Tanaka Eikichi Ihara Keita Fukaura Kei Nishioka Takatoshi Chinen Yoshimasa Tanaka Jiro Nakayama Dongchon Kang Yoshihiro Ogawa
author_facet	Yuichiro Nishihara Haruei Ogino Masaru Tanaka Eikichi Ihara Keita Fukaura Kei Nishioka Takatoshi Chinen Yoshimasa Tanaka Jiro Nakayama Dongchon Kang Yoshihiro Ogawa
author_sort	Yuichiro Nishihara
title	Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis
title_short	Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis
title_full	Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis
title_fullStr	Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis
title_full_unstemmed	Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis
title_sort	mucosa-associated gut microbiota reflects clinical course of ulcerative colitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1358905895eb46d3bb842e2fa402d545
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Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis

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