Material advancement in tissue-engineered nerve conduit

Peripheral nerve injuries resulting from various traumatic events can cause mobility problems and sensory impairment, jeopardizing patients’ life quality and bringing serious economic burdens. Due to the shortcomings of autologous nerve grafts, such as limited tissue sources, unmatched size, and los...

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Autores principales:	Dai Wufei, Yang Yating, Yang Yumin, Liu Wei
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	tissue-engineered nerve conduit conduit materials advancement peripheral nerve regeneration Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
Acceso en línea:	https://doaj.org/article/13594a38aa8f4276a6dd822f2c94aa12
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id	oai:doaj.org-article:13594a38aa8f4276a6dd822f2c94aa12
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spelling	oai:doaj.org-article:13594a38aa8f4276a6dd822f2c94aa122021-12-05T14:10:57ZMaterial advancement in tissue-engineered nerve conduit2191-909710.1515/ntrev-2021-0028https://doaj.org/article/13594a38aa8f4276a6dd822f2c94aa122021-06-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0028https://doaj.org/toc/2191-9097Peripheral nerve injuries resulting from various traumatic events can cause mobility problems and sensory impairment, jeopardizing patients’ life quality and bringing serious economic burdens. Due to the shortcomings of autologous nerve grafts, such as limited tissue sources, unmatched size, and loss of innervation at the donor site, tissue-engineered nerve grafts using both natural and synthetic materials have been employed in the treatment of peripheral nerve defect and to promote nerve regeneration. Apart from traditional advantages such as good biocompatibility and controllable degradation, the development of fabrication technology and the advancement in material science have endowed tissue-engineered nerve conduits with upgraded properties such as biomimetic surface topography, extracellular matrix components, neurotrophic factors, and cell seeding, or a conduit with micropores on the surface for substance exchange and/or with fillers inside for microenvironment simulation. This article reviews recent progress in the biomaterials employed in fabricating tissue-engineered nerve conduits, in vitro characterization, and their applications in nerve repair in animal studies as well as in clinical trials.Dai WufeiYang YatingYang YuminLiu WeiDe Gruyterarticletissue-engineered nerve conduitconduit materials advancementperipheral nerve regenerationTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 488-503 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tissue-engineered nerve conduit conduit materials advancement peripheral nerve regeneration Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
spellingShingle	tissue-engineered nerve conduit conduit materials advancement peripheral nerve regeneration Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 Dai Wufei Yang Yating Yang Yumin Liu Wei Material advancement in tissue-engineered nerve conduit
description	Peripheral nerve injuries resulting from various traumatic events can cause mobility problems and sensory impairment, jeopardizing patients’ life quality and bringing serious economic burdens. Due to the shortcomings of autologous nerve grafts, such as limited tissue sources, unmatched size, and loss of innervation at the donor site, tissue-engineered nerve grafts using both natural and synthetic materials have been employed in the treatment of peripheral nerve defect and to promote nerve regeneration. Apart from traditional advantages such as good biocompatibility and controllable degradation, the development of fabrication technology and the advancement in material science have endowed tissue-engineered nerve conduits with upgraded properties such as biomimetic surface topography, extracellular matrix components, neurotrophic factors, and cell seeding, or a conduit with micropores on the surface for substance exchange and/or with fillers inside for microenvironment simulation. This article reviews recent progress in the biomaterials employed in fabricating tissue-engineered nerve conduits, in vitro characterization, and their applications in nerve repair in animal studies as well as in clinical trials.
format	article
author	Dai Wufei Yang Yating Yang Yumin Liu Wei
author_facet	Dai Wufei Yang Yating Yang Yumin Liu Wei
author_sort	Dai Wufei
title	Material advancement in tissue-engineered nerve conduit
title_short	Material advancement in tissue-engineered nerve conduit
title_full	Material advancement in tissue-engineered nerve conduit
title_fullStr	Material advancement in tissue-engineered nerve conduit
title_full_unstemmed	Material advancement in tissue-engineered nerve conduit
title_sort	material advancement in tissue-engineered nerve conduit
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/13594a38aa8f4276a6dd822f2c94aa12
work_keys_str_mv	AT daiwufei materialadvancementintissueengineerednerveconduit AT yangyating materialadvancementintissueengineerednerveconduit AT yangyumin materialadvancementintissueengineerednerveconduit AT liuwei materialadvancementintissueengineerednerveconduit
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Material advancement in tissue-engineered nerve conduit

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