A beamformer analysis of MEG data reveals frontal generators of the musically elicited mismatch negativity.

To localize the neural generators of the musically elicited mismatch negativity with high temporal resolution we conducted a beamformer analysis (Synthetic Aperture Magnetometry, SAM) on magnetoencephalography (MEG) data from a previous musical mismatch study. The stimuli consisted of a six-tone mel...

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Autores principales:	Claudia Lappe, Olaf Steinsträter, Christo Pantev
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13598145aae6462eadbecc81f55923d2
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spelling	oai:doaj.org-article:13598145aae6462eadbecc81f55923d22021-11-18T07:50:01ZA beamformer analysis of MEG data reveals frontal generators of the musically elicited mismatch negativity.1932-620310.1371/journal.pone.0061296https://doaj.org/article/13598145aae6462eadbecc81f55923d22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23585888/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203To localize the neural generators of the musically elicited mismatch negativity with high temporal resolution we conducted a beamformer analysis (Synthetic Aperture Magnetometry, SAM) on magnetoencephalography (MEG) data from a previous musical mismatch study. The stimuli consisted of a six-tone melodic sequence comprising broken chords in C- and G-major. The musical sequence was presented within an oddball paradigm in which the last tone was lowered occasionally (20%) by a minor third. The beamforming analysis revealed significant right hemispheric neural activation in the superior temporal (STC), inferior frontal (IFC), superior frontal (SFC) and orbitofrontal (OFC) cortices within a time window of 100-200 ms after the occurrence of a deviant tone. IFC and SFC activation was also observed in the left hemisphere. The pronounced early right inferior frontal activation of the auditory mismatch negativity has not been shown in MEG studies so far. The activation in STC and IFC is consistent with earlier electroencephalography (EEG), optical imaging and functional magnetic resonance imaging (fMRI) studies that reveal the auditory and inferior frontal cortices as main generators of the auditory MMN. The observed right hemispheric IFC is also in line with some previous music studies showing similar activation patterns after harmonic syntactic violations. The results demonstrate that a deviant tone within a musical sequence recruits immediately a distributed neural network in frontal and prefrontal areas suggesting that top-down processes are involved when expectation violation occurs within well-known stimuli.Claudia LappeOlaf SteinsträterChristo PantevPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61296 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claudia Lappe Olaf Steinsträter Christo Pantev A beamformer analysis of MEG data reveals frontal generators of the musically elicited mismatch negativity.
description	To localize the neural generators of the musically elicited mismatch negativity with high temporal resolution we conducted a beamformer analysis (Synthetic Aperture Magnetometry, SAM) on magnetoencephalography (MEG) data from a previous musical mismatch study. The stimuli consisted of a six-tone melodic sequence comprising broken chords in C- and G-major. The musical sequence was presented within an oddball paradigm in which the last tone was lowered occasionally (20%) by a minor third. The beamforming analysis revealed significant right hemispheric neural activation in the superior temporal (STC), inferior frontal (IFC), superior frontal (SFC) and orbitofrontal (OFC) cortices within a time window of 100-200 ms after the occurrence of a deviant tone. IFC and SFC activation was also observed in the left hemisphere. The pronounced early right inferior frontal activation of the auditory mismatch negativity has not been shown in MEG studies so far. The activation in STC and IFC is consistent with earlier electroencephalography (EEG), optical imaging and functional magnetic resonance imaging (fMRI) studies that reveal the auditory and inferior frontal cortices as main generators of the auditory MMN. The observed right hemispheric IFC is also in line with some previous music studies showing similar activation patterns after harmonic syntactic violations. The results demonstrate that a deviant tone within a musical sequence recruits immediately a distributed neural network in frontal and prefrontal areas suggesting that top-down processes are involved when expectation violation occurs within well-known stimuli.
format	article
author	Claudia Lappe Olaf Steinsträter Christo Pantev
author_facet	Claudia Lappe Olaf Steinsträter Christo Pantev
author_sort	Claudia Lappe
title	A beamformer analysis of MEG data reveals frontal generators of the musically elicited mismatch negativity.
title_short	A beamformer analysis of MEG data reveals frontal generators of the musically elicited mismatch negativity.
title_full	A beamformer analysis of MEG data reveals frontal generators of the musically elicited mismatch negativity.
title_fullStr	A beamformer analysis of MEG data reveals frontal generators of the musically elicited mismatch negativity.
title_full_unstemmed	A beamformer analysis of MEG data reveals frontal generators of the musically elicited mismatch negativity.
title_sort	beamformer analysis of meg data reveals frontal generators of the musically elicited mismatch negativity.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/13598145aae6462eadbecc81f55923d2
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A beamformer analysis of MEG data reveals frontal generators of the musically elicited mismatch negativity.

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