Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering

Regenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tiss...

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Autores principales:	Astha Khanna, Maedeh Zamani, Ngan F. Huang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tissue engineering regenerative medicine extracellular matrix (ECM) Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/1359a94f9a6746b89afc83a54e83fed8
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spelling	oai:doaj.org-article:1359a94f9a6746b89afc83a54e83fed82021-11-25T18:00:13ZExtracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering10.3390/jcdd81101372308-3425https://doaj.org/article/1359a94f9a6746b89afc83a54e83fed82021-10-01T00:00:00Zhttps://www.mdpi.com/2308-3425/8/11/137https://doaj.org/toc/2308-3425Regenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tissue-engineered replacements. The extracellular matrix (ECM) is a dynamic scaffolding structure characterized by tissue-specific biochemical, biophysical, and mechanical properties that modulates cellular behavior and activates highly regulated signaling pathways. In light of technological advancements, biomaterial-based scaffolds have been developed that better mimic physiological ECM properties, provide signaling cues that modulate cellular behavior, and form functional tissues and organs. In this review, we summarize the in vitro, pre-clinical, and clinical research models that have been employed in the design of ECM-based biomaterials for cardiovascular regenerative medicine. We highlight the research advancements in the incorporation of ECM components into biomaterial-based scaffolds, the engineering of increasingly complex structures using biofabrication and spatial patterning techniques, the regulation of ECMs on vascular differentiation and function, and the translation of ECM-based scaffolds for vascular graft applications. Finally, we discuss the challenges, future perspectives, and directions in the design of next-generation ECM-based biomaterials for cardiovascular tissue engineering and clinical translation.Astha KhannaMaedeh ZamaniNgan F. HuangMDPI AGarticletissue engineeringregenerative medicineextracellular matrix (ECM)Diseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Cardiovascular Development and Disease, Vol 8, Iss 137, p 137 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tissue engineering regenerative medicine extracellular matrix (ECM) Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	tissue engineering regenerative medicine extracellular matrix (ECM) Diseases of the circulatory (Cardiovascular) system RC666-701 Astha Khanna Maedeh Zamani Ngan F. Huang Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering
description	Regenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tissue-engineered replacements. The extracellular matrix (ECM) is a dynamic scaffolding structure characterized by tissue-specific biochemical, biophysical, and mechanical properties that modulates cellular behavior and activates highly regulated signaling pathways. In light of technological advancements, biomaterial-based scaffolds have been developed that better mimic physiological ECM properties, provide signaling cues that modulate cellular behavior, and form functional tissues and organs. In this review, we summarize the in vitro, pre-clinical, and clinical research models that have been employed in the design of ECM-based biomaterials for cardiovascular regenerative medicine. We highlight the research advancements in the incorporation of ECM components into biomaterial-based scaffolds, the engineering of increasingly complex structures using biofabrication and spatial patterning techniques, the regulation of ECMs on vascular differentiation and function, and the translation of ECM-based scaffolds for vascular graft applications. Finally, we discuss the challenges, future perspectives, and directions in the design of next-generation ECM-based biomaterials for cardiovascular tissue engineering and clinical translation.
format	article
author	Astha Khanna Maedeh Zamani Ngan F. Huang
author_facet	Astha Khanna Maedeh Zamani Ngan F. Huang
author_sort	Astha Khanna
title	Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering
title_short	Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering
title_full	Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering
title_fullStr	Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering
title_full_unstemmed	Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering
title_sort	extracellular matrix-based biomaterials for cardiovascular tissue engineering
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1359a94f9a6746b89afc83a54e83fed8
work_keys_str_mv	AT asthakhanna extracellularmatrixbasedbiomaterialsforcardiovasculartissueengineering AT maedehzamani extracellularmatrixbasedbiomaterialsforcardiovasculartissueengineering AT nganfhuang extracellularmatrixbasedbiomaterialsforcardiovasculartissueengineering
_version_	1718411724818743296

Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering

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