RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

Adenosine deaminase acting on RNA 1 (ADAR1) edits adenosine to inosine. Here the authors, using parallel analysis of RNA secondary structure sequencing, provide evidence that ADAR1 induces sequence-context-dependent RNA secondary structures changes, often leading to stabilization of the RNA duplex.

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Autores principales:	Oz Solomon, Ayelet Di Segni, Karen Cesarkas, Hagit T. Porath, Victoria Marcu-Malina, Orel Mizrahi, Noam Stern-Ginossar, Nitzan Kol, Sarit Farage-Barhom, Efrat Glick-Saar, Yaniv Lerenthal, Erez Y. Levanon, Ninette Amariglio, Ron Unger, Itamar Goldstein, Eran Eyal, Gidi Rechavi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/135bc3a86dbd4e62a8694058deaacfb0
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spelling	oai:doaj.org-article:135bc3a86dbd4e62a8694058deaacfb02021-12-02T15:39:02ZRNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure10.1038/s41467-017-01458-82041-1723https://doaj.org/article/135bc3a86dbd4e62a8694058deaacfb02017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01458-8https://doaj.org/toc/2041-1723Adenosine deaminase acting on RNA 1 (ADAR1) edits adenosine to inosine. Here the authors, using parallel analysis of RNA secondary structure sequencing, provide evidence that ADAR1 induces sequence-context-dependent RNA secondary structures changes, often leading to stabilization of the RNA duplex.Oz SolomonAyelet Di SegniKaren CesarkasHagit T. PorathVictoria Marcu-MalinaOrel MizrahiNoam Stern-GinossarNitzan KolSarit Farage-BarhomEfrat Glick-SaarYaniv LerenthalErez Y. LevanonNinette AmariglioRon UngerItamar GoldsteinEran EyalGidi RechaviNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Oz Solomon Ayelet Di Segni Karen Cesarkas Hagit T. Porath Victoria Marcu-Malina Orel Mizrahi Noam Stern-Ginossar Nitzan Kol Sarit Farage-Barhom Efrat Glick-Saar Yaniv Lerenthal Erez Y. Levanon Ninette Amariglio Ron Unger Itamar Goldstein Eran Eyal Gidi Rechavi RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure
description	Adenosine deaminase acting on RNA 1 (ADAR1) edits adenosine to inosine. Here the authors, using parallel analysis of RNA secondary structure sequencing, provide evidence that ADAR1 induces sequence-context-dependent RNA secondary structures changes, often leading to stabilization of the RNA duplex.
format	article
author	Oz Solomon Ayelet Di Segni Karen Cesarkas Hagit T. Porath Victoria Marcu-Malina Orel Mizrahi Noam Stern-Ginossar Nitzan Kol Sarit Farage-Barhom Efrat Glick-Saar Yaniv Lerenthal Erez Y. Levanon Ninette Amariglio Ron Unger Itamar Goldstein Eran Eyal Gidi Rechavi
author_facet	Oz Solomon Ayelet Di Segni Karen Cesarkas Hagit T. Porath Victoria Marcu-Malina Orel Mizrahi Noam Stern-Ginossar Nitzan Kol Sarit Farage-Barhom Efrat Glick-Saar Yaniv Lerenthal Erez Y. Levanon Ninette Amariglio Ron Unger Itamar Goldstein Eran Eyal Gidi Rechavi
author_sort	Oz Solomon
title	RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure
title_short	RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure
title_full	RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure
title_fullStr	RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure
title_full_unstemmed	RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure
title_sort	rna editing by adar1 leads to context-dependent transcriptome-wide changes in rna secondary structure
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/135bc3a86dbd4e62a8694058deaacfb0
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RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

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