Use of skeletal muscle index as a predictor of short-term mortality in patients with acute-on-chronic liver failure

Abstract Sarcopenia is a well-recognized factor affecting the prognosis of chronic liver disease, but its impact on acute decompensation underlying chronic liver disease is unknown. This study evaluated the impact of sarcopenia on short-term mortality in patients with acute-on-chronic liver failure...

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Autores principales:	Tongzeng Li, Manman Xu, Ming Kong, Wenyan Song, Zhongping Duan, Yu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/135e1346dda943a595eb3d450879c131
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spelling	oai:doaj.org-article:135e1346dda943a595eb3d450879c1312021-12-02T17:23:26ZUse of skeletal muscle index as a predictor of short-term mortality in patients with acute-on-chronic liver failure10.1038/s41598-021-92087-12045-2322https://doaj.org/article/135e1346dda943a595eb3d450879c1312021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92087-1https://doaj.org/toc/2045-2322Abstract Sarcopenia is a well-recognized factor affecting the prognosis of chronic liver disease, but its impact on acute decompensation underlying chronic liver disease is unknown. This study evaluated the impact of sarcopenia on short-term mortality in patients with acute-on-chronic liver failure (ACLF). One hundred and seventy-one ACLF patients who underwent abdominal CT between 2015 and 2019 were retrospectively included in this study. Skeletal muscle index at the third lumbar vertebrae (L3-SMI) was used to diagnose sarcopenia.The ACLF patients in this study had a L3-SMI of 41.2 ± 8.3 cm2/m2 and sarcopenia was present in 95/171 (55.6%) patients. Body mass index (BMI), cirrhosis, and higher serum bilirubin were independently associated with sarcopenia. Following multivariate Cox regression analysis, cirrhosis (hazard ratio (HR) 2.758, 95%CI 1.323–5.750), serum bilirubin (HR 1.049, 95%CI 1.026–1.073), and international normalized ratio (INR) (HR 1.725, 95%CI 1.263–2.355) were associated with 3-month mortality (P < 0.05), whereas L3-SMI and sarcopenia were not. A subgroup analysis of the factors related to sarcopenia showed that sarcopenia was still not predictive of short-term outcome in ACLF patients. L3-SMI and sarcopenia are not associated with short-term mortality in patients with ACLF.Tongzeng LiManman XuMing KongWenyan SongZhongping DuanYu ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tongzeng Li Manman Xu Ming Kong Wenyan Song Zhongping Duan Yu Chen Use of skeletal muscle index as a predictor of short-term mortality in patients with acute-on-chronic liver failure
description	Abstract Sarcopenia is a well-recognized factor affecting the prognosis of chronic liver disease, but its impact on acute decompensation underlying chronic liver disease is unknown. This study evaluated the impact of sarcopenia on short-term mortality in patients with acute-on-chronic liver failure (ACLF). One hundred and seventy-one ACLF patients who underwent abdominal CT between 2015 and 2019 were retrospectively included in this study. Skeletal muscle index at the third lumbar vertebrae (L3-SMI) was used to diagnose sarcopenia.The ACLF patients in this study had a L3-SMI of 41.2 ± 8.3 cm2/m2 and sarcopenia was present in 95/171 (55.6%) patients. Body mass index (BMI), cirrhosis, and higher serum bilirubin were independently associated with sarcopenia. Following multivariate Cox regression analysis, cirrhosis (hazard ratio (HR) 2.758, 95%CI 1.323–5.750), serum bilirubin (HR 1.049, 95%CI 1.026–1.073), and international normalized ratio (INR) (HR 1.725, 95%CI 1.263–2.355) were associated with 3-month mortality (P < 0.05), whereas L3-SMI and sarcopenia were not. A subgroup analysis of the factors related to sarcopenia showed that sarcopenia was still not predictive of short-term outcome in ACLF patients. L3-SMI and sarcopenia are not associated with short-term mortality in patients with ACLF.
format	article
author	Tongzeng Li Manman Xu Ming Kong Wenyan Song Zhongping Duan Yu Chen
author_facet	Tongzeng Li Manman Xu Ming Kong Wenyan Song Zhongping Duan Yu Chen
author_sort	Tongzeng Li
title	Use of skeletal muscle index as a predictor of short-term mortality in patients with acute-on-chronic liver failure
title_short	Use of skeletal muscle index as a predictor of short-term mortality in patients with acute-on-chronic liver failure
title_full	Use of skeletal muscle index as a predictor of short-term mortality in patients with acute-on-chronic liver failure
title_fullStr	Use of skeletal muscle index as a predictor of short-term mortality in patients with acute-on-chronic liver failure
title_full_unstemmed	Use of skeletal muscle index as a predictor of short-term mortality in patients with acute-on-chronic liver failure
title_sort	use of skeletal muscle index as a predictor of short-term mortality in patients with acute-on-chronic liver failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/135e1346dda943a595eb3d450879c131
work_keys_str_mv	AT tongzengli useofskeletalmuscleindexasapredictorofshorttermmortalityinpatientswithacuteonchronicliverfailure AT manmanxu useofskeletalmuscleindexasapredictorofshorttermmortalityinpatientswithacuteonchronicliverfailure AT mingkong useofskeletalmuscleindexasapredictorofshorttermmortalityinpatientswithacuteonchronicliverfailure AT wenyansong useofskeletalmuscleindexasapredictorofshorttermmortalityinpatientswithacuteonchronicliverfailure AT zhongpingduan useofskeletalmuscleindexasapredictorofshorttermmortalityinpatientswithacuteonchronicliverfailure AT yuchen useofskeletalmuscleindexasapredictorofshorttermmortalityinpatientswithacuteonchronicliverfailure
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Use of skeletal muscle index as a predictor of short-term mortality in patients with acute-on-chronic liver failure

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