Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is redirected from the mitochondria to the nucleus.

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Detalles Bibliográficos
Autores principales: Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis, Thomas Carell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/135f870c99dd4995a292de8aef187119
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Descripción
Sumario:α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is redirected from the mitochondria to the nucleus.

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