Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is redirected from the mitochondria to the nucleus.

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Autores principales:	Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis, Thomas Carell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/135f870c99dd4995a292de8aef187119
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spelling	oai:doaj.org-article:135f870c99dd4995a292de8aef1871192021-12-02T14:34:05ZRedirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons10.1038/s41467-021-24353-92041-1723https://doaj.org/article/135f870c99dd4995a292de8aef1871192021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24353-9https://doaj.org/toc/2041-1723α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is redirected from the mitochondria to the nucleus.Franziska R. TraubeDilara ÖzdemirHanife SahinConstanze ScheelAndrea F. GlückAnna S. GeserichSabine OganesianSarantos KostidisKatharina IwanRené RahimoffGrazia GiorgioMarkus MüllerFabio SpadaMartin BielJürgen CoxMartin GieraStylianos MichalakisThomas CarellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Franziska R. Traube Dilara Özdemir Hanife Sahin Constanze Scheel Andrea F. Glück Anna S. Geserich Sabine Oganesian Sarantos Kostidis Katharina Iwan René Rahimoff Grazia Giorgio Markus Müller Fabio Spada Martin Biel Jürgen Cox Martin Giera Stylianos Michalakis Thomas Carell Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons
description	α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is redirected from the mitochondria to the nucleus.
format	article
author	Franziska R. Traube Dilara Özdemir Hanife Sahin Constanze Scheel Andrea F. Glück Anna S. Geserich Sabine Oganesian Sarantos Kostidis Katharina Iwan René Rahimoff Grazia Giorgio Markus Müller Fabio Spada Martin Biel Jürgen Cox Martin Giera Stylianos Michalakis Thomas Carell
author_facet	Franziska R. Traube Dilara Özdemir Hanife Sahin Constanze Scheel Andrea F. Glück Anna S. Geserich Sabine Oganesian Sarantos Kostidis Katharina Iwan René Rahimoff Grazia Giorgio Markus Müller Fabio Spada Martin Biel Jürgen Cox Martin Giera Stylianos Michalakis Thomas Carell
author_sort	Franziska R. Traube
title	Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons
title_short	Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons
title_full	Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons
title_fullStr	Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons
title_full_unstemmed	Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons
title_sort	redirected nuclear glutamate dehydrogenase supplies tet3 with α-ketoglutarate in neurons
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/135f870c99dd4995a292de8aef187119
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Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

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