New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis

Deborah Lim Chua, Thomas Hahambis, Samuel H SigalDivision of Gastroenterology, Department of Medicine, New York University School of Medicine, New York, NY, USABackground: Chronic hepatitis C is the most common cause of cirrhosis in industrialized countries. Successful treatment of chronic hepatiti...

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Autores principales:	Chua DL, Hahambis T, Sigal SH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/1365723b10d94865a94db6e9bff5cc78
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spelling	oai:doaj.org-article:1365723b10d94865a94db6e9bff5cc782021-12-02T09:16:09ZNew-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis1179-1535https://doaj.org/article/1365723b10d94865a94db6e9bff5cc782014-01-01T00:00:00Zhttp://www.dovepress.com/new-onset-ascites-as-a-manifestation-of-virologic-relapse-in-patients--a15646https://doaj.org/toc/1179-1535 Deborah Lim Chua, Thomas Hahambis, Samuel H SigalDivision of Gastroenterology, Department of Medicine, New York University School of Medicine, New York, NY, USABackground: Chronic hepatitis C is the most common cause of cirrhosis in industrialized countries. Successful treatment of chronic hepatitis C in patients with advanced fibrosis or cirrhosis has significant benefits, including improvements in inflammation, fibrosis, and portal hypertension, with prevention of esophageal varices and clinical decompensation.Case: In this report, we present two patients with well-compensated hepatitis C cirrhosis who achieved an end-of-treatment response on a direct-acting antiviral therapy-based triple regimen for hepatitis C virus, but subsequently presented with new-onset ascites associated with virologic relapse.Conclusion: We propose that the development of ascites in this setting is due to the adverse impact of inflammation of the virologic relapse on portal hypertension. Our observation that ascites formation can be a manifestation of virologic relapse has potentially important clinical implications, as it highlights not only the importance of close monitoring of cirrhotic patients after achieving end-of-treatment response but also the impact of active inflammation on the severity of portal hypertension.Keywords: chronic hepatitis C, cirrhosis, virologic relapse, portal hypertension, ascitesChua DLHahambis TSigal SHDove Medical PressarticleDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2014, Iss default, Pp 11-14 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Chua DL Hahambis T Sigal SH New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis
description	Deborah Lim Chua, Thomas Hahambis, Samuel H SigalDivision of Gastroenterology, Department of Medicine, New York University School of Medicine, New York, NY, USABackground: Chronic hepatitis C is the most common cause of cirrhosis in industrialized countries. Successful treatment of chronic hepatitis C in patients with advanced fibrosis or cirrhosis has significant benefits, including improvements in inflammation, fibrosis, and portal hypertension, with prevention of esophageal varices and clinical decompensation.Case: In this report, we present two patients with well-compensated hepatitis C cirrhosis who achieved an end-of-treatment response on a direct-acting antiviral therapy-based triple regimen for hepatitis C virus, but subsequently presented with new-onset ascites associated with virologic relapse.Conclusion: We propose that the development of ascites in this setting is due to the adverse impact of inflammation of the virologic relapse on portal hypertension. Our observation that ascites formation can be a manifestation of virologic relapse has potentially important clinical implications, as it highlights not only the importance of close monitoring of cirrhotic patients after achieving end-of-treatment response but also the impact of active inflammation on the severity of portal hypertension.Keywords: chronic hepatitis C, cirrhosis, virologic relapse, portal hypertension, ascites
format	article
author	Chua DL Hahambis T Sigal SH
author_facet	Chua DL Hahambis T Sigal SH
author_sort	Chua DL
title	New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis
title_short	New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis
title_full	New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis
title_fullStr	New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis
title_full_unstemmed	New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis
title_sort	new-onset ascites as a manifestation of virologic relapse in patients with hepatitis c cirrhosis
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/1365723b10d94865a94db6e9bff5cc78
work_keys_str_mv	AT chuadl newonsetascitesasamanifestationofvirologicrelapseinpatientswithhepatitisccirrhosis AT hahambist newonsetascitesasamanifestationofvirologicrelapseinpatientswithhepatitisccirrhosis AT sigalsh newonsetascitesasamanifestationofvirologicrelapseinpatientswithhepatitisccirrhosis
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New-onset ascites as a manifestation of virologic relapse in patients with hepatitis C cirrhosis

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