A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage.

A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage.

<h4>Background</h4>Exposure of adherent cells to DNA damaging agents, such as the bacterial cytolethal distending toxin (CDT) or ionizing radiations (IR), activates the small GTPase RhoA, which promotes the formation of actin stress fibers and delays cell death. The signalling intermedia...

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Autores principales: Lina Guerra, Heather S Carr, Agneta Richter-Dahlfors, Maria G Masucci, Monica Thelestam, Jeffrey A Frost, Teresa Frisan
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/13685e220b60404b877b4cb86ec0367a
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