Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis

Systemic sclerosis (SSc) is a disease with manifestation in the skin and immune etiology, but the pathogenic immune cell types remain unidentified. Here the authors use ATAC-seq to profile chromatin landscapes of skin samples from patients with SSc to implicate skin dendritic cells for having the st...

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Autores principales:	Qian Liu, Lisa C. Zaba, Ansuman T. Satpathy, Michelle Longmire, Wen Zhang, Kun Li, Jeffrey Granja, Chuang Guo, Jun Lin, Rui Li, Karen Tolentino, Gabriela Kania, Oliver Distler, David Fiorentino, Lorinda Chung, Kun Qu, Howard Y. Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/136a9ffc01a74f60ae540dd0b3a7288f
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spelling	oai:doaj.org-article:136a9ffc01a74f60ae540dd0b3a7288f2021-12-02T15:39:11ZChromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis10.1038/s41467-020-19702-z2041-1723https://doaj.org/article/136a9ffc01a74f60ae540dd0b3a7288f2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19702-zhttps://doaj.org/toc/2041-1723Systemic sclerosis (SSc) is a disease with manifestation in the skin and immune etiology, but the pathogenic immune cell types remain unidentified. Here the authors use ATAC-seq to profile chromatin landscapes of skin samples from patients with SSc to implicate skin dendritic cells for having the strongest disease-associated epigenetic changes.Qian LiuLisa C. ZabaAnsuman T. SatpathyMichelle LongmireWen ZhangKun LiJeffrey GranjaChuang GuoJun LinRui LiKaren TolentinoGabriela KaniaOliver DistlerDavid FiorentinoLorinda ChungKun QuHoward Y. ChangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian Liu Lisa C. Zaba Ansuman T. Satpathy Michelle Longmire Wen Zhang Kun Li Jeffrey Granja Chuang Guo Jun Lin Rui Li Karen Tolentino Gabriela Kania Oliver Distler David Fiorentino Lorinda Chung Kun Qu Howard Y. Chang Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis
description	Systemic sclerosis (SSc) is a disease with manifestation in the skin and immune etiology, but the pathogenic immune cell types remain unidentified. Here the authors use ATAC-seq to profile chromatin landscapes of skin samples from patients with SSc to implicate skin dendritic cells for having the strongest disease-associated epigenetic changes.
format	article
author	Qian Liu Lisa C. Zaba Ansuman T. Satpathy Michelle Longmire Wen Zhang Kun Li Jeffrey Granja Chuang Guo Jun Lin Rui Li Karen Tolentino Gabriela Kania Oliver Distler David Fiorentino Lorinda Chung Kun Qu Howard Y. Chang
author_facet	Qian Liu Lisa C. Zaba Ansuman T. Satpathy Michelle Longmire Wen Zhang Kun Li Jeffrey Granja Chuang Guo Jun Lin Rui Li Karen Tolentino Gabriela Kania Oliver Distler David Fiorentino Lorinda Chung Kun Qu Howard Y. Chang
author_sort	Qian Liu
title	Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis
title_short	Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis
title_full	Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis
title_fullStr	Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis
title_full_unstemmed	Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis
title_sort	chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/136a9ffc01a74f60ae540dd0b3a7288f
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Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis

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