Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial

Abstract With the world's population aging, age-related memory decline is an impending cognitive epidemic. Assessing the impact of diet on cognitive aging, we conducted a controlled, randomized, parallel-arm dietary intervention with 211 healthy adults (50–75 years) investigating effects of eit...

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Autores principales:	Richard P. Sloan, Melanie Wall, Lok-Kin Yeung, Tianshu Feng, Xinyang Feng, Frank Provenzano, Hagen Schroeter, Vincenzo Lauriola, Adam M. Brickman, Scott A. Small
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/136ab5a0d12347c7806bb87435516791
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spelling	oai:doaj.org-article:136ab5a0d12347c7806bb874355167912021-12-02T14:21:53ZInsights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial10.1038/s41598-021-83370-22045-2322https://doaj.org/article/136ab5a0d12347c7806bb874355167912021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83370-2https://doaj.org/toc/2045-2322Abstract With the world's population aging, age-related memory decline is an impending cognitive epidemic. Assessing the impact of diet on cognitive aging, we conducted a controlled, randomized, parallel-arm dietary intervention with 211 healthy adults (50–75 years) investigating effects of either a placebo or 260, 510 and 770 mg/day of cocoa flavanols for 12-weeks followed by 8-weeks washout. The primary outcome was a newly-developed object-recognition task localized to the hippocampus’ dentate gyrus. Secondary outcomes included a hippocampal-dependent list-learning task and a prefrontal cortex-dependent list-sorting task. The alternative Healthy Eating Index and a biomarker of flavanol intake (gVLM) were measured. In an MRI substudy, hippocampal cerebral blood volume was mapped. Object-recognition and list-sorting performance did not correlate with baseline diet quality and did not improve after flavanol intake. However, the hippocampal-dependent list-learning performance was directly associated with baseline diet quality and improved after flavanol intake, particularly in participants in the bottom tertile of baseline diet quality. In the imaging substudy, a region-of-interest analysis was negative but a voxel-based-analysis suggested that dietary flavanols target the dentate gyrus. While replication is needed, these findings suggest that diet in general, and dietary flavanols in particular, may be associated with memory function of the aging hippocampus and normal cognitive decline.Richard P. SloanMelanie WallLok-Kin YeungTianshu FengXinyang FengFrank ProvenzanoHagen SchroeterVincenzo LauriolaAdam M. BrickmanScott A. SmallNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Richard P. Sloan Melanie Wall Lok-Kin Yeung Tianshu Feng Xinyang Feng Frank Provenzano Hagen Schroeter Vincenzo Lauriola Adam M. Brickman Scott A. Small Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial
description	Abstract With the world's population aging, age-related memory decline is an impending cognitive epidemic. Assessing the impact of diet on cognitive aging, we conducted a controlled, randomized, parallel-arm dietary intervention with 211 healthy adults (50–75 years) investigating effects of either a placebo or 260, 510 and 770 mg/day of cocoa flavanols for 12-weeks followed by 8-weeks washout. The primary outcome was a newly-developed object-recognition task localized to the hippocampus’ dentate gyrus. Secondary outcomes included a hippocampal-dependent list-learning task and a prefrontal cortex-dependent list-sorting task. The alternative Healthy Eating Index and a biomarker of flavanol intake (gVLM) were measured. In an MRI substudy, hippocampal cerebral blood volume was mapped. Object-recognition and list-sorting performance did not correlate with baseline diet quality and did not improve after flavanol intake. However, the hippocampal-dependent list-learning performance was directly associated with baseline diet quality and improved after flavanol intake, particularly in participants in the bottom tertile of baseline diet quality. In the imaging substudy, a region-of-interest analysis was negative but a voxel-based-analysis suggested that dietary flavanols target the dentate gyrus. While replication is needed, these findings suggest that diet in general, and dietary flavanols in particular, may be associated with memory function of the aging hippocampus and normal cognitive decline.
format	article
author	Richard P. Sloan Melanie Wall Lok-Kin Yeung Tianshu Feng Xinyang Feng Frank Provenzano Hagen Schroeter Vincenzo Lauriola Adam M. Brickman Scott A. Small
author_facet	Richard P. Sloan Melanie Wall Lok-Kin Yeung Tianshu Feng Xinyang Feng Frank Provenzano Hagen Schroeter Vincenzo Lauriola Adam M. Brickman Scott A. Small
author_sort	Richard P. Sloan
title	Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial
title_short	Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial
title_full	Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial
title_fullStr	Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial
title_full_unstemmed	Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial
title_sort	insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/136ab5a0d12347c7806bb87435516791
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Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial

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