Normal Saline Solution or Lactated Ringer’s Solution to Enhance Lactate Clearance in Septic Patients After Initial Resuscitation in the ED: A Retrospective Cohort Trial

Normal Saline Solution or Lactated Ringer’s Solution to Enhance Lactate Clearance in Septic Patients After Initial Resuscitation in the ED: A Retrospective Cohort Trial

Thanya Limapichat, Krittapat Pattanapong Department of Emergency Medicine, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, ThailandCorrespondence: Thanya LimapichatDepartment of Emergency Medicine, Songklanagarind Hospital, Faculty of Medicine, Prince...

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Autores principales: Limapichat T, Pattanapong K
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
lactate clearance
balance crystalloid
sepsis
news
Medical emergencies. Critical care. Intensive care. First aid
RC86-88.9
Acceso en línea:https://doaj.org/article/136b7d00c46140bb87d6910a8ab8ed11
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spelling oai:doaj.org-article:136b7d00c46140bb87d6910a8ab8ed112021-11-30T18:50:37ZNormal Saline Solution or Lactated Ringer’s Solution to Enhance Lactate Clearance in Septic Patients After Initial Resuscitation in the ED: A Retrospective Cohort Trial1179-1500https://doaj.org/article/136b7d00c46140bb87d6910a8ab8ed112021-12-01T00:00:00Zhttps://www.dovepress.com/normal-saline-solution-or-lactated-ringers-solution-to-enhance-lactate-peer-reviewed-fulltext-article-OAEMhttps://doaj.org/toc/1179-1500Thanya Limapichat, Krittapat Pattanapong Department of Emergency Medicine, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, ThailandCorrespondence: Thanya LimapichatDepartment of Emergency Medicine, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, ThailandTel +66 74-451705Fax +66 74-451704Email thanya_nl@yahoo.comObjective: To compare the effect of isotonic crystalloid solutions between lactated Ringer’s solution (LRS) and normal saline solution (NSS) on lactate clearance in septic patients at the emergency department (ED).Materials and Methods: This study is a single-center retrospective chart review. The study enrolled patients older than 18 years with sepsis and initial serum lactate level > 2 mg/dL in the ED. The primary outcome was to determine which isotonic solution was better for serum lactate clearance in septic patients. The secondary outcomes were serum creatinine change within 24 h and the 48-h survival rate after admission.Results: A total of 120 patients were enrolled with a median crystalloid volume administered in the ED of 1000 mL. Within 2 h of resuscitation, there was no difference in lactate clearance between the LRS and NSS groups with median values of 29.2% and 25%, respectively (P=0.839). The 48-h survival rate after admission did not differ between the LRS and NSS groups with median values of 90% and 86%, respectively. Both isotonic solutions increased serum creatinine levels within 24 h of treatment with median values of 0.3 for each group (P=0.647).Conclusion: Among septic patients in the ED treated with NSS or LRS, there was no difference in lactate clearance, serum creatinine change within 24 h, or 48-h survival. However, several factors were associated with increased lactate levels, such as older age and use of vasopressors and immunosuppressive agents.Keywords: lactate clearance, balance crystalloid, sepsis, NEWSLimapichat TPattanapong KDove Medical Pressarticlelactate clearancebalance crystalloidsepsisnewsMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENOpen Access Emergency Medicine, Vol Volume 13, Pp 511-519 (2021)
institution DOAJ
collection DOAJ
language EN
topic lactate clearance
balance crystalloid
sepsis
news
Medical emergencies. Critical care. Intensive care. First aid
RC86-88.9
spellingShingle lactate clearance
balance crystalloid
sepsis
news
Medical emergencies. Critical care. Intensive care. First aid
RC86-88.9
Limapichat T
Pattanapong K
Normal Saline Solution or Lactated Ringer’s Solution to Enhance Lactate Clearance in Septic Patients After Initial Resuscitation in the ED: A Retrospective Cohort Trial
description Thanya Limapichat, Krittapat Pattanapong Department of Emergency Medicine, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, ThailandCorrespondence: Thanya LimapichatDepartment of Emergency Medicine, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, ThailandTel +66 74-451705Fax +66 74-451704Email thanya_nl@yahoo.comObjective: To compare the effect of isotonic crystalloid solutions between lactated Ringer’s solution (LRS) and normal saline solution (NSS) on lactate clearance in septic patients at the emergency department (ED).Materials and Methods: This study is a single-center retrospective chart review. The study enrolled patients older than 18 years with sepsis and initial serum lactate level > 2 mg/dL in the ED. The primary outcome was to determine which isotonic solution was better for serum lactate clearance in septic patients. The secondary outcomes were serum creatinine change within 24 h and the 48-h survival rate after admission.Results: A total of 120 patients were enrolled with a median crystalloid volume administered in the ED of 1000 mL. Within 2 h of resuscitation, there was no difference in lactate clearance between the LRS and NSS groups with median values of 29.2% and 25%, respectively (P=0.839). The 48-h survival rate after admission did not differ between the LRS and NSS groups with median values of 90% and 86%, respectively. Both isotonic solutions increased serum creatinine levels within 24 h of treatment with median values of 0.3 for each group (P=0.647).Conclusion: Among septic patients in the ED treated with NSS or LRS, there was no difference in lactate clearance, serum creatinine change within 24 h, or 48-h survival. However, several factors were associated with increased lactate levels, such as older age and use of vasopressors and immunosuppressive agents.Keywords: lactate clearance, balance crystalloid, sepsis, NEWS
format article
author Limapichat T
Pattanapong K
author_facet Limapichat T
Pattanapong K
author_sort Limapichat T
title Normal Saline Solution or Lactated Ringer’s Solution to Enhance Lactate Clearance in Septic Patients After Initial Resuscitation in the ED: A Retrospective Cohort Trial
title_short Normal Saline Solution or Lactated Ringer’s Solution to Enhance Lactate Clearance in Septic Patients After Initial Resuscitation in the ED: A Retrospective Cohort Trial
title_full Normal Saline Solution or Lactated Ringer’s Solution to Enhance Lactate Clearance in Septic Patients After Initial Resuscitation in the ED: A Retrospective Cohort Trial
title_fullStr Normal Saline Solution or Lactated Ringer’s Solution to Enhance Lactate Clearance in Septic Patients After Initial Resuscitation in the ED: A Retrospective Cohort Trial
title_full_unstemmed Normal Saline Solution or Lactated Ringer’s Solution to Enhance Lactate Clearance in Septic Patients After Initial Resuscitation in the ED: A Retrospective Cohort Trial
title_sort normal saline solution or lactated ringer’s solution to enhance lactate clearance in septic patients after initial resuscitation in the ed: a retrospective cohort trial
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/136b7d00c46140bb87d6910a8ab8ed11
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AT pattanapongk normalsalinesolutionorlactatedringerrsquossolutiontoenhancelactateclearanceinsepticpatientsafterinitialresuscitationintheedaretrospectivecohorttrial
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