Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats

Abstract Hypertensive subjects often exhibit exaggerated cardiovascular reactivity. An overactive orexin system underlies the pathophysiology of hypertension. We examined orexin’s roles in eating-associated cardiovascular reactivity in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) ra...

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Autores principales:	Shang-Cheng Huang, Tzu-Ling Li, Yen-Hsien Lee, Yu-Wen E. Dai, Yu-Chun Chen, Ling-Ling Hwang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/136be00c15c0495080e69d58b7cc4c14
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spelling	oai:doaj.org-article:136be00c15c0495080e69d58b7cc4c142021-12-02T15:08:11ZRole of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats10.1038/s41598-018-30970-02045-2322https://doaj.org/article/136be00c15c0495080e69d58b7cc4c142018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30970-0https://doaj.org/toc/2045-2322Abstract Hypertensive subjects often exhibit exaggerated cardiovascular reactivity. An overactive orexin system underlies the pathophysiology of hypertension. We examined orexin’s roles in eating-associated cardiovascular reactivity in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats. Results showed eating regular chow or palatable food (sucrose agar) was accompanied by elevated arterial pressure and heart rate. In both SHRs and WKY rats, the cardiovascular responses associated with sucrose-agar consumption were greater than that with regular-chow consumption. Additionally, SHRs exhibited greater cardiovascular responses than WKY rats did to regular-chow and palatable food consumption. Central orexin 2 receptor (OX2R) blockade attenuated sucrose-agar consumption-associated cardiovascular response only in SHRs. In both SHRs and WKY rats, OX2R blockade did not affect regular-chow consumption-associated cardiovascular responses. Greater numbers of c-Fos-positive cells in the rostral ventrolateral medulla (RVLM) and of c-Fos-positive orexin neurons in the dorsomedial hypothalamus (DMH) were detected in sucrose agar-treated SHRs, compared to regular chow-treated SHRs and to sucrose agar-treated WKY rats. Central OX2R blockade reduced the number of c-Fos-positive cells in the RVLM only in sucrose agar-treated SHRs. We concluded that in SHRs, orexin neurons in the DMH might be overactive during eating palatable food and may further elicit exaggerated cardiovascular responses via an OX2R-RVLM pathway.Shang-Cheng HuangTzu-Ling LiYen-Hsien LeeYu-Wen E. DaiYu-Chun ChenLing-Ling HwangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shang-Cheng Huang Tzu-Ling Li Yen-Hsien Lee Yu-Wen E. Dai Yu-Chun Chen Ling-Ling Hwang Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats
description	Abstract Hypertensive subjects often exhibit exaggerated cardiovascular reactivity. An overactive orexin system underlies the pathophysiology of hypertension. We examined orexin’s roles in eating-associated cardiovascular reactivity in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats. Results showed eating regular chow or palatable food (sucrose agar) was accompanied by elevated arterial pressure and heart rate. In both SHRs and WKY rats, the cardiovascular responses associated with sucrose-agar consumption were greater than that with regular-chow consumption. Additionally, SHRs exhibited greater cardiovascular responses than WKY rats did to regular-chow and palatable food consumption. Central orexin 2 receptor (OX2R) blockade attenuated sucrose-agar consumption-associated cardiovascular response only in SHRs. In both SHRs and WKY rats, OX2R blockade did not affect regular-chow consumption-associated cardiovascular responses. Greater numbers of c-Fos-positive cells in the rostral ventrolateral medulla (RVLM) and of c-Fos-positive orexin neurons in the dorsomedial hypothalamus (DMH) were detected in sucrose agar-treated SHRs, compared to regular chow-treated SHRs and to sucrose agar-treated WKY rats. Central OX2R blockade reduced the number of c-Fos-positive cells in the RVLM only in sucrose agar-treated SHRs. We concluded that in SHRs, orexin neurons in the DMH might be overactive during eating palatable food and may further elicit exaggerated cardiovascular responses via an OX2R-RVLM pathway.
format	article
author	Shang-Cheng Huang Tzu-Ling Li Yen-Hsien Lee Yu-Wen E. Dai Yu-Chun Chen Ling-Ling Hwang
author_facet	Shang-Cheng Huang Tzu-Ling Li Yen-Hsien Lee Yu-Wen E. Dai Yu-Chun Chen Ling-Ling Hwang
author_sort	Shang-Cheng Huang
title	Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats
title_short	Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats
title_full	Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats
title_fullStr	Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats
title_full_unstemmed	Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats
title_sort	role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/136be00c15c0495080e69d58b7cc4c14
work_keys_str_mv	AT shangchenghuang roleoftheorexin2receptorinpalatablefoodconsumptionassociatedcardiovascularreactivityinspontaneouslyhypertensiverats AT tzulingli roleoftheorexin2receptorinpalatablefoodconsumptionassociatedcardiovascularreactivityinspontaneouslyhypertensiverats AT yenhsienlee roleoftheorexin2receptorinpalatablefoodconsumptionassociatedcardiovascularreactivityinspontaneouslyhypertensiverats AT yuwenedai roleoftheorexin2receptorinpalatablefoodconsumptionassociatedcardiovascularreactivityinspontaneouslyhypertensiverats AT yuchunchen roleoftheorexin2receptorinpalatablefoodconsumptionassociatedcardiovascularreactivityinspontaneouslyhypertensiverats AT linglinghwang roleoftheorexin2receptorinpalatablefoodconsumptionassociatedcardiovascularreactivityinspontaneouslyhypertensiverats
_version_	1718388234704125952

Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats

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