E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning

In multi-layered epithelia tight junctions (TJ) are confined to the most suprabasal viable layer. Here the authors show that this is regulated by ubiquitously localized E-cadherin tuning junctional tension and EGFR activity to inhibit TJ formation in lower layers while promoting TJ stability in the...

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Autores principales:	Matthias Rübsam, Aaron F. Mertz, Akiharu Kubo, Susanna Marg, Christian Jüngst, Gladiola Goranci-Buzhala, Astrid C. Schauss, Valerie Horsley, Eric R. Dufresne, Markus Moser, Wolfgang Ziegler, Masayuki Amagai, Sara A. Wickström, Carien M. Niessen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13725cc72379417abbcc0dbb0fa23102
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spelling	oai:doaj.org-article:13725cc72379417abbcc0dbb0fa231022021-12-02T15:37:05ZE-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning10.1038/s41467-017-01170-72041-1723https://doaj.org/article/13725cc72379417abbcc0dbb0fa231022017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01170-7https://doaj.org/toc/2041-1723In multi-layered epithelia tight junctions (TJ) are confined to the most suprabasal viable layer. Here the authors show that this is regulated by ubiquitously localized E-cadherin tuning junctional tension and EGFR activity to inhibit TJ formation in lower layers while promoting TJ stability in the granular layer 2.Matthias RübsamAaron F. MertzAkiharu KuboSusanna MargChristian JüngstGladiola Goranci-BuzhalaAstrid C. SchaussValerie HorsleyEric R. DufresneMarkus MoserWolfgang ZieglerMasayuki AmagaiSara A. WickströmCarien M. NiessenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthias Rübsam Aaron F. Mertz Akiharu Kubo Susanna Marg Christian Jüngst Gladiola Goranci-Buzhala Astrid C. Schauss Valerie Horsley Eric R. Dufresne Markus Moser Wolfgang Ziegler Masayuki Amagai Sara A. Wickström Carien M. Niessen E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning
description	In multi-layered epithelia tight junctions (TJ) are confined to the most suprabasal viable layer. Here the authors show that this is regulated by ubiquitously localized E-cadherin tuning junctional tension and EGFR activity to inhibit TJ formation in lower layers while promoting TJ stability in the granular layer 2.
format	article
author	Matthias Rübsam Aaron F. Mertz Akiharu Kubo Susanna Marg Christian Jüngst Gladiola Goranci-Buzhala Astrid C. Schauss Valerie Horsley Eric R. Dufresne Markus Moser Wolfgang Ziegler Masayuki Amagai Sara A. Wickström Carien M. Niessen
author_facet	Matthias Rübsam Aaron F. Mertz Akiharu Kubo Susanna Marg Christian Jüngst Gladiola Goranci-Buzhala Astrid C. Schauss Valerie Horsley Eric R. Dufresne Markus Moser Wolfgang Ziegler Masayuki Amagai Sara A. Wickström Carien M. Niessen
author_sort	Matthias Rübsam
title	E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning
title_short	E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning
title_full	E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning
title_fullStr	E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning
title_full_unstemmed	E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning
title_sort	e-cadherin integrates mechanotransduction and egfr signaling to control junctional tissue polarization and tight junction positioning
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/13725cc72379417abbcc0dbb0fa23102
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E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning

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