The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN

Abstract Recently, substantial evidence has demonstrated that pseudogene derived lncRNAs are crucial regulators of cancer development and progression. DUXAP10,a pseudogene derived long non-coding RNA(lncRNA), is overexpression in colorectal cancer (CRC), but its expression pattern, biological functi...

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Autores principales:	Yifan Lian, Yetao Xu, Chuanxing Xiao, Rui Xia, Huangbo Gong, Peng Yang, Tao Chen, Dongdong Wu, Zeling Cai, Jianping Zhang, Keming Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1373bd91eb3444db874ccc0ed059aa07
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spelling	oai:doaj.org-article:1373bd91eb3444db874ccc0ed059aa072021-12-02T12:32:01ZThe pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN10.1038/s41598-017-07954-72045-2322https://doaj.org/article/1373bd91eb3444db874ccc0ed059aa072017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07954-7https://doaj.org/toc/2045-2322Abstract Recently, substantial evidence has demonstrated that pseudogene derived lncRNAs are crucial regulators of cancer development and progression. DUXAP10,a pseudogene derived long non-coding RNA(lncRNA), is overexpression in colorectal cancer (CRC), but its expression pattern, biological function and underlying mechanism in CRC is still undetermined. In this study, we observed that DUXAP10 was up-regulated in CRC tissues which was positively correlated with advanced pathological stages, larger tumor sizes and lymph node metastasis. Additionally, knockdown of DUXAP10 inhibited cell proliferation, induced cell apoptosis and increase the number of G0/G1 cells significantly in the HCT116 and SW480 cell lines. Moreover, DUXAP10 silencing inhibited tumor growth in vivo. Further mechanism study showed that, by binding to histone demethylase lysine-specific demethylase 1 (LSD1), DUXAP10 promote CRC cell growth and reduced cell apoptosis through silencing the expression of p21 and phosphatase and tensin homolog (PTEN) tumor suppressor. Our findings suggested that the pseudogene-derived from lncRNA DUXAP10 promotes the biological progression of CRC and is likely to be a potential therapeutic target for CRC intervention.Yifan LianYetao XuChuanxing XiaoRui XiaHuangbo GongPeng YangTao ChenDongdong WuZeling CaiJianping ZhangKeming WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yifan Lian Yetao Xu Chuanxing Xiao Rui Xia Huangbo Gong Peng Yang Tao Chen Dongdong Wu Zeling Cai Jianping Zhang Keming Wang The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN
description	Abstract Recently, substantial evidence has demonstrated that pseudogene derived lncRNAs are crucial regulators of cancer development and progression. DUXAP10,a pseudogene derived long non-coding RNA(lncRNA), is overexpression in colorectal cancer (CRC), but its expression pattern, biological function and underlying mechanism in CRC is still undetermined. In this study, we observed that DUXAP10 was up-regulated in CRC tissues which was positively correlated with advanced pathological stages, larger tumor sizes and lymph node metastasis. Additionally, knockdown of DUXAP10 inhibited cell proliferation, induced cell apoptosis and increase the number of G0/G1 cells significantly in the HCT116 and SW480 cell lines. Moreover, DUXAP10 silencing inhibited tumor growth in vivo. Further mechanism study showed that, by binding to histone demethylase lysine-specific demethylase 1 (LSD1), DUXAP10 promote CRC cell growth and reduced cell apoptosis through silencing the expression of p21 and phosphatase and tensin homolog (PTEN) tumor suppressor. Our findings suggested that the pseudogene-derived from lncRNA DUXAP10 promotes the biological progression of CRC and is likely to be a potential therapeutic target for CRC intervention.
format	article
author	Yifan Lian Yetao Xu Chuanxing Xiao Rui Xia Huangbo Gong Peng Yang Tao Chen Dongdong Wu Zeling Cai Jianping Zhang Keming Wang
author_facet	Yifan Lian Yetao Xu Chuanxing Xiao Rui Xia Huangbo Gong Peng Yang Tao Chen Dongdong Wu Zeling Cai Jianping Zhang Keming Wang
author_sort	Yifan Lian
title	The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN
title_short	The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN
title_full	The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN
title_fullStr	The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN
title_full_unstemmed	The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN
title_sort	pseudogene derived from long non-coding rna duxap10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and pten
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1373bd91eb3444db874ccc0ed059aa07
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The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN

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