Antimicrobial use on 74 Japanese pig farms in 2019: A comparison of Japanese and European defined daily doses in the field.

Defined daily doses (DDD) have been established in human medicine to standardize the measurement of treatment in a population. In veterinary medicine, the European Medicine Agency published defined daily dose (DDDvet) values for antimicrobial agents used in food-producing animals in 2016. National d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kyoko Fujimoto, Mai Kawasaki, Yuko Endo, Takashi Yokoyama, Itsuro Yamane, Hisanori Yamazaki, Katsumasa Kure, Takeshi Haga, Katsuaki Sugiura
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1376e7b2eb934bb5b4af2c79646c8bc6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1376e7b2eb934bb5b4af2c79646c8bc6
record_format	dspace
spelling	oai:doaj.org-article:1376e7b2eb934bb5b4af2c79646c8bc62021-12-02T20:15:08ZAntimicrobial use on 74 Japanese pig farms in 2019: A comparison of Japanese and European defined daily doses in the field.1932-620310.1371/journal.pone.0255632https://doaj.org/article/1376e7b2eb934bb5b4af2c79646c8bc62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255632https://doaj.org/toc/1932-6203Defined daily doses (DDD) have been established in human medicine to standardize the measurement of treatment in a population. In veterinary medicine, the European Medicine Agency published defined daily dose (DDDvet) values for antimicrobial agents used in food-producing animals in 2016. National defined doses (DDDjp) for antimicrobials used for pigs in Japan have recently been determined. The aim of this study was to compare the results of calculated antimicrobial use in the field using the DDDjp and DDDvet values. Data from 74 pig farms in Japan relative to antimicrobial use in 2019 was collected. The numbers of DDDs (the weight of biomass treated in kg-days) using DDDjp and DDDvet values for each farm and for different antimicrobial classes were compared. Associations between calculated numbers of DDDjp and DDDvet on farm level were investigated. In addition, differences in antimicrobial use were investigated between different production types of farms (farrowing, finishing and farrow-to-finish farms). Using DDDjp and DDDvet values, the aggregated number of DDDs for 74 farms were 4,099,188 and 2,217,085 respectively, with the former being larger by 1.85 times than the latter. The most frequently used antimicrobial class was penicillin regardless of whether DDDjp or DDDvet was used. The absence of DDDvet values for certain antimicrobial agents used in Japan and the differences in the number of DDDjps/PCU and DDDvets/PCU indicated the need for Japanese DDDs. The number of DDDs per kg population correction unit (PCU) per farm tended to be higher in farrowing farms than in farrow-to-finish farms and finishing farms, with no significant difference (P = 0.19).Kyoko FujimotoMai KawasakiYuko EndoTakashi YokoyamaItsuro YamaneHisanori YamazakiKatsumasa KureTakeshi HagaKatsuaki SugiuraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255632 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyoko Fujimoto Mai Kawasaki Yuko Endo Takashi Yokoyama Itsuro Yamane Hisanori Yamazaki Katsumasa Kure Takeshi Haga Katsuaki Sugiura Antimicrobial use on 74 Japanese pig farms in 2019: A comparison of Japanese and European defined daily doses in the field.
description	Defined daily doses (DDD) have been established in human medicine to standardize the measurement of treatment in a population. In veterinary medicine, the European Medicine Agency published defined daily dose (DDDvet) values for antimicrobial agents used in food-producing animals in 2016. National defined doses (DDDjp) for antimicrobials used for pigs in Japan have recently been determined. The aim of this study was to compare the results of calculated antimicrobial use in the field using the DDDjp and DDDvet values. Data from 74 pig farms in Japan relative to antimicrobial use in 2019 was collected. The numbers of DDDs (the weight of biomass treated in kg-days) using DDDjp and DDDvet values for each farm and for different antimicrobial classes were compared. Associations between calculated numbers of DDDjp and DDDvet on farm level were investigated. In addition, differences in antimicrobial use were investigated between different production types of farms (farrowing, finishing and farrow-to-finish farms). Using DDDjp and DDDvet values, the aggregated number of DDDs for 74 farms were 4,099,188 and 2,217,085 respectively, with the former being larger by 1.85 times than the latter. The most frequently used antimicrobial class was penicillin regardless of whether DDDjp or DDDvet was used. The absence of DDDvet values for certain antimicrobial agents used in Japan and the differences in the number of DDDjps/PCU and DDDvets/PCU indicated the need for Japanese DDDs. The number of DDDs per kg population correction unit (PCU) per farm tended to be higher in farrowing farms than in farrow-to-finish farms and finishing farms, with no significant difference (P = 0.19).
format	article
author	Kyoko Fujimoto Mai Kawasaki Yuko Endo Takashi Yokoyama Itsuro Yamane Hisanori Yamazaki Katsumasa Kure Takeshi Haga Katsuaki Sugiura
author_facet	Kyoko Fujimoto Mai Kawasaki Yuko Endo Takashi Yokoyama Itsuro Yamane Hisanori Yamazaki Katsumasa Kure Takeshi Haga Katsuaki Sugiura
author_sort	Kyoko Fujimoto
title	Antimicrobial use on 74 Japanese pig farms in 2019: A comparison of Japanese and European defined daily doses in the field.
title_short	Antimicrobial use on 74 Japanese pig farms in 2019: A comparison of Japanese and European defined daily doses in the field.
title_full	Antimicrobial use on 74 Japanese pig farms in 2019: A comparison of Japanese and European defined daily doses in the field.
title_fullStr	Antimicrobial use on 74 Japanese pig farms in 2019: A comparison of Japanese and European defined daily doses in the field.
title_full_unstemmed	Antimicrobial use on 74 Japanese pig farms in 2019: A comparison of Japanese and European defined daily doses in the field.
title_sort	antimicrobial use on 74 japanese pig farms in 2019: a comparison of japanese and european defined daily doses in the field.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1376e7b2eb934bb5b4af2c79646c8bc6
work_keys_str_mv	AT kyokofujimoto antimicrobialuseon74japanesepigfarmsin2019acomparisonofjapaneseandeuropeandefineddailydosesinthefield AT maikawasaki antimicrobialuseon74japanesepigfarmsin2019acomparisonofjapaneseandeuropeandefineddailydosesinthefield AT yukoendo antimicrobialuseon74japanesepigfarmsin2019acomparisonofjapaneseandeuropeandefineddailydosesinthefield AT takashiyokoyama antimicrobialuseon74japanesepigfarmsin2019acomparisonofjapaneseandeuropeandefineddailydosesinthefield AT itsuroyamane antimicrobialuseon74japanesepigfarmsin2019acomparisonofjapaneseandeuropeandefineddailydosesinthefield AT hisanoriyamazaki antimicrobialuseon74japanesepigfarmsin2019acomparisonofjapaneseandeuropeandefineddailydosesinthefield AT katsumasakure antimicrobialuseon74japanesepigfarmsin2019acomparisonofjapaneseandeuropeandefineddailydosesinthefield AT takeshihaga antimicrobialuseon74japanesepigfarmsin2019acomparisonofjapaneseandeuropeandefineddailydosesinthefield AT katsuakisugiura antimicrobialuseon74japanesepigfarmsin2019acomparisonofjapaneseandeuropeandefineddailydosesinthefield
_version_	1718374568580612096

Antimicrobial use on 74 Japanese pig farms in 2019: A comparison of Japanese and European defined daily doses in the field.

Ejemplares similares