Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma
Rhabdomyosarcomas are tumours blocked in myogenic differentiation, which despite the expression of master muscle regulatory factors, including MYOD, are unable to differentiate. Here, the authors show that SNAI2 is upregulated by MYOD through super enhancers, binds to MYOD target enhancers, and arre...
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Nature Portfolio
2021
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oai:doaj.org-article:13792164b2674112a670f2c8b5793e7e2021-12-02T11:45:55ZInteraction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma10.1038/s41467-020-20386-82041-1723https://doaj.org/article/13792164b2674112a670f2c8b5793e7e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20386-8https://doaj.org/toc/2041-1723Rhabdomyosarcomas are tumours blocked in myogenic differentiation, which despite the expression of master muscle regulatory factors, including MYOD, are unable to differentiate. Here, the authors show that SNAI2 is upregulated by MYOD through super enhancers, binds to MYOD target enhancers, and arrests differentiation.Silvia PomellaPrethish SreenivasBerkley E. GryderLong WangDavid MilewskiMatteo CassandriKunal BaxiNicole R. HenschElena CarcarinoYoung SongHsien-Chao ChouMarielle E. YoheBenjamin Z. StantonBruno AmadioIgnazio CaruanaCristiano De StefanisRita De VitoFranco LocatelliYidong ChenEleanor Y. ChenPeter HoughtonJaved KhanRossella RotaMyron S. IgnatiusNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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DOAJ |
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Science Q |
| spellingShingle |
Science Q Silvia Pomella Prethish Sreenivas Berkley E. Gryder Long Wang David Milewski Matteo Cassandri Kunal Baxi Nicole R. Hensch Elena Carcarino Young Song Hsien-Chao Chou Marielle E. Yohe Benjamin Z. Stanton Bruno Amadio Ignazio Caruana Cristiano De Stefanis Rita De Vito Franco Locatelli Yidong Chen Eleanor Y. Chen Peter Houghton Javed Khan Rossella Rota Myron S. Ignatius Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma |
| description |
Rhabdomyosarcomas are tumours blocked in myogenic differentiation, which despite the expression of master muscle regulatory factors, including MYOD, are unable to differentiate. Here, the authors show that SNAI2 is upregulated by MYOD through super enhancers, binds to MYOD target enhancers, and arrests differentiation. |
| format |
article |
| author |
Silvia Pomella Prethish Sreenivas Berkley E. Gryder Long Wang David Milewski Matteo Cassandri Kunal Baxi Nicole R. Hensch Elena Carcarino Young Song Hsien-Chao Chou Marielle E. Yohe Benjamin Z. Stanton Bruno Amadio Ignazio Caruana Cristiano De Stefanis Rita De Vito Franco Locatelli Yidong Chen Eleanor Y. Chen Peter Houghton Javed Khan Rossella Rota Myron S. Ignatius |
| author_facet |
Silvia Pomella Prethish Sreenivas Berkley E. Gryder Long Wang David Milewski Matteo Cassandri Kunal Baxi Nicole R. Hensch Elena Carcarino Young Song Hsien-Chao Chou Marielle E. Yohe Benjamin Z. Stanton Bruno Amadio Ignazio Caruana Cristiano De Stefanis Rita De Vito Franco Locatelli Yidong Chen Eleanor Y. Chen Peter Houghton Javed Khan Rossella Rota Myron S. Ignatius |
| author_sort |
Silvia Pomella |
| title |
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma |
| title_short |
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma |
| title_full |
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma |
| title_fullStr |
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma |
| title_full_unstemmed |
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma |
| title_sort |
interaction between snai2 and myod enhances oncogenesis and suppresses differentiation in fusion negative rhabdomyosarcoma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/13792164b2674112a670f2c8b5793e7e |
| work_keys_str_mv |
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