Radiation‐Induced Cardiovascular Disease: Review of an Underrecognized Pathology

Abstract Radiation therapy demonstrates a clear survival benefit in the treatment of several malignancies. However, cancer survivors can develop a wide array of cardiotoxic complications related to radiation. This pathology is often underrecognized by clinicians and there is little known on how to m...

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Autores principales:	Eve Belzile‐Dugas, Mark J. Eisenberg
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cancer survivors cardiomyopathies cardiotoxicity cardiovascular diseases coronary artery disease fibrosis Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/137bd5c36b50446097989f94bbc44e53
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spelling	oai:doaj.org-article:137bd5c36b50446097989f94bbc44e532021-11-23T11:36:36ZRadiation‐Induced Cardiovascular Disease: Review of an Underrecognized Pathology10.1161/JAHA.121.0216862047-9980https://doaj.org/article/137bd5c36b50446097989f94bbc44e532021-09-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.121.021686https://doaj.org/toc/2047-9980Abstract Radiation therapy demonstrates a clear survival benefit in the treatment of several malignancies. However, cancer survivors can develop a wide array of cardiotoxic complications related to radiation. This pathology is often underrecognized by clinicians and there is little known on how to manage this population. Radiation causes fibrosis of all components of the heart and significantly increases the risk of coronary artery disease, cardiomyopathy, valvulopathy, arrhythmias, and pericardial disease. Physicians should treat other cardiovascular risk factors aggressively in this population and guidelines suggest obtaining regular imaging once symptomatology is established. Patients with radiation‐induced cardiovascular disease tend to do worse than their traditional counterparts for the same interventions. However, there is a trend toward fewer complications and lower mortality with catheter‐based rather than surgical approaches, likely because radiation makes these patients poor surgical candidates. When appropriate, these patients should be referred for percutaneous management of valvulopathy and coronary disease.Eve Belzile‐DugasMark J. EisenbergWileyarticlecancer survivorscardiomyopathiescardiotoxicitycardiovascular diseasescoronary artery diseasefibrosisDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer survivors cardiomyopathies cardiotoxicity cardiovascular diseases coronary artery disease fibrosis Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	cancer survivors cardiomyopathies cardiotoxicity cardiovascular diseases coronary artery disease fibrosis Diseases of the circulatory (Cardiovascular) system RC666-701 Eve Belzile‐Dugas Mark J. Eisenberg Radiation‐Induced Cardiovascular Disease: Review of an Underrecognized Pathology
description	Abstract Radiation therapy demonstrates a clear survival benefit in the treatment of several malignancies. However, cancer survivors can develop a wide array of cardiotoxic complications related to radiation. This pathology is often underrecognized by clinicians and there is little known on how to manage this population. Radiation causes fibrosis of all components of the heart and significantly increases the risk of coronary artery disease, cardiomyopathy, valvulopathy, arrhythmias, and pericardial disease. Physicians should treat other cardiovascular risk factors aggressively in this population and guidelines suggest obtaining regular imaging once symptomatology is established. Patients with radiation‐induced cardiovascular disease tend to do worse than their traditional counterparts for the same interventions. However, there is a trend toward fewer complications and lower mortality with catheter‐based rather than surgical approaches, likely because radiation makes these patients poor surgical candidates. When appropriate, these patients should be referred for percutaneous management of valvulopathy and coronary disease.
format	article
author	Eve Belzile‐Dugas Mark J. Eisenberg
author_facet	Eve Belzile‐Dugas Mark J. Eisenberg
author_sort	Eve Belzile‐Dugas
title	Radiation‐Induced Cardiovascular Disease: Review of an Underrecognized Pathology
title_short	Radiation‐Induced Cardiovascular Disease: Review of an Underrecognized Pathology
title_full	Radiation‐Induced Cardiovascular Disease: Review of an Underrecognized Pathology
title_fullStr	Radiation‐Induced Cardiovascular Disease: Review of an Underrecognized Pathology
title_full_unstemmed	Radiation‐Induced Cardiovascular Disease: Review of an Underrecognized Pathology
title_sort	radiation‐induced cardiovascular disease: review of an underrecognized pathology
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/137bd5c36b50446097989f94bbc44e53
work_keys_str_mv	AT evebelziledugas radiationinducedcardiovasculardiseasereviewofanunderrecognizedpathology AT markjeisenberg radiationinducedcardiovasculardiseasereviewofanunderrecognizedpathology
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Radiation‐Induced Cardiovascular Disease: Review of an Underrecognized Pathology

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