Hypoglycemia due to an adult-onset nesidioblastosis, a diagnostic and management dilemma

We describe a case of a 40 year old patient with recurrent severe fasting and postprandial symptomatic hypoglycemia that occurred 6 years after gastric bypass surgery. The hypoglycemia was associated with increased insulin and C peptide but all diagnostic modalities for localizing an insulinoma were...

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Autores principales: Mohammed Qintar, Firas Sibai, Mohammad Taha
Formato: article
Lenguaje:EN
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2012
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Acceso en línea:https://doaj.org/article/137c3fc8f1bd47e4a1a2abf3e914605c
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spelling oai:doaj.org-article:137c3fc8f1bd47e4a1a2abf3e914605c2021-12-02T16:24:51ZHypoglycemia due to an adult-onset nesidioblastosis, a diagnostic and management dilemma2231-07702249-446410.4103/2231-0770.99164https://doaj.org/article/137c3fc8f1bd47e4a1a2abf3e914605c2012-04-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.99164https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464We describe a case of a 40 year old patient with recurrent severe fasting and postprandial symptomatic hypoglycemia that occurred 6 years after gastric bypass surgery. The hypoglycemia was associated with increased insulin and C peptide but all diagnostic modalities for localizing an insulinoma were negative. Medical management failed to control symptoms and the patient underwent subtotal pancreatectomy. Surgical tissue examination confirmed the diagnosis of noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS) or nesidioblastosis. Initially after surgery the patient had full remission but after 6 months hypoglycemia recurred. However, this time it was well-controlled with octreotide treatment.Mohammed QintarFiras SibaiMohammad TahaThieme Medical and Scientific Publishers Pvt. Ltd.articlehypoglycemianesidioblastosisgastric bypass surgerynoninsulinoma pancreatogenous hypoglycaemia syndromeniphsMedicineRENAvicenna Journal of Medicine, Vol 02, Iss 02, Pp 45-47 (2012)
institution DOAJ
collection DOAJ
language EN
topic hypoglycemia
nesidioblastosis
gastric bypass surgery
noninsulinoma pancreatogenous hypoglycaemia syndrome
niphs
Medicine
R
spellingShingle hypoglycemia
nesidioblastosis
gastric bypass surgery
noninsulinoma pancreatogenous hypoglycaemia syndrome
niphs
Medicine
R
Mohammed Qintar
Firas Sibai
Mohammad Taha
Hypoglycemia due to an adult-onset nesidioblastosis, a diagnostic and management dilemma
description We describe a case of a 40 year old patient with recurrent severe fasting and postprandial symptomatic hypoglycemia that occurred 6 years after gastric bypass surgery. The hypoglycemia was associated with increased insulin and C peptide but all diagnostic modalities for localizing an insulinoma were negative. Medical management failed to control symptoms and the patient underwent subtotal pancreatectomy. Surgical tissue examination confirmed the diagnosis of noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS) or nesidioblastosis. Initially after surgery the patient had full remission but after 6 months hypoglycemia recurred. However, this time it was well-controlled with octreotide treatment.
format article
author Mohammed Qintar
Firas Sibai
Mohammad Taha
author_facet Mohammed Qintar
Firas Sibai
Mohammad Taha
author_sort Mohammed Qintar
title Hypoglycemia due to an adult-onset nesidioblastosis, a diagnostic and management dilemma
title_short Hypoglycemia due to an adult-onset nesidioblastosis, a diagnostic and management dilemma
title_full Hypoglycemia due to an adult-onset nesidioblastosis, a diagnostic and management dilemma
title_fullStr Hypoglycemia due to an adult-onset nesidioblastosis, a diagnostic and management dilemma
title_full_unstemmed Hypoglycemia due to an adult-onset nesidioblastosis, a diagnostic and management dilemma
title_sort hypoglycemia due to an adult-onset nesidioblastosis, a diagnostic and management dilemma
publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate 2012
url https://doaj.org/article/137c3fc8f1bd47e4a1a2abf3e914605c
work_keys_str_mv AT mohammedqintar hypoglycemiaduetoanadultonsetnesidioblastosisadiagnosticandmanagementdilemma
AT firassibai hypoglycemiaduetoanadultonsetnesidioblastosisadiagnosticandmanagementdilemma
AT mohammadtaha hypoglycemiaduetoanadultonsetnesidioblastosisadiagnosticandmanagementdilemma
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