Development of Array-Based Gold Nanoclusters for Discrimination of CA125 Overexpressed Serum Samples

Here, we reported a simple method for recognizing CA125 overexpressed serum samples using array-based fluorescent gold nanoclusters (AuNCs). The sensing array was fabricated by the combination of various CA125 aptamer functionalized AuNCs. The fluorescence of different aptamer-capped AuNCs was quenc...

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Autores principales:	Yi Shi, Xianhui Gao, Wei Wei, Youguo Chen
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/1380d2a375a74a348ecd19bbfaf0087e
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spelling	oai:doaj.org-article:1380d2a375a74a348ecd19bbfaf0087e2021-11-22T01:09:39ZDevelopment of Array-Based Gold Nanoclusters for Discrimination of CA125 Overexpressed Serum Samples1687-844210.1155/2021/7326552https://doaj.org/article/1380d2a375a74a348ecd19bbfaf0087e2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7326552https://doaj.org/toc/1687-8442Here, we reported a simple method for recognizing CA125 overexpressed serum samples using array-based fluorescent gold nanoclusters (AuNCs). The sensing array was fabricated by the combination of various CA125 aptamer functionalized AuNCs. The fluorescence of different aptamer-capped AuNCs was quenched to a different extent in the presence of CA125. By comprehensive analysis of these fluorescence changes, unique patterns were formed when CA125 was overexpressed in serum samples. This strategy is successfully used for discriminating CA125 overexpressed human serum samples, which have great importance for the diagnosis of ovarian cancer in the early stage.Yi ShiXianhui GaoWei WeiYouguo ChenHindawi LimitedarticleMaterials of engineering and construction. Mechanics of materialsTA401-492ENAdvances in Materials Science and Engineering, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	Materials of engineering and construction. Mechanics of materials TA401-492 Yi Shi Xianhui Gao Wei Wei Youguo Chen Development of Array-Based Gold Nanoclusters for Discrimination of CA125 Overexpressed Serum Samples
description	Here, we reported a simple method for recognizing CA125 overexpressed serum samples using array-based fluorescent gold nanoclusters (AuNCs). The sensing array was fabricated by the combination of various CA125 aptamer functionalized AuNCs. The fluorescence of different aptamer-capped AuNCs was quenched to a different extent in the presence of CA125. By comprehensive analysis of these fluorescence changes, unique patterns were formed when CA125 was overexpressed in serum samples. This strategy is successfully used for discriminating CA125 overexpressed human serum samples, which have great importance for the diagnosis of ovarian cancer in the early stage.
format	article
author	Yi Shi Xianhui Gao Wei Wei Youguo Chen
author_facet	Yi Shi Xianhui Gao Wei Wei Youguo Chen
author_sort	Yi Shi
title	Development of Array-Based Gold Nanoclusters for Discrimination of CA125 Overexpressed Serum Samples
title_short	Development of Array-Based Gold Nanoclusters for Discrimination of CA125 Overexpressed Serum Samples
title_full	Development of Array-Based Gold Nanoclusters for Discrimination of CA125 Overexpressed Serum Samples
title_fullStr	Development of Array-Based Gold Nanoclusters for Discrimination of CA125 Overexpressed Serum Samples
title_full_unstemmed	Development of Array-Based Gold Nanoclusters for Discrimination of CA125 Overexpressed Serum Samples
title_sort	development of array-based gold nanoclusters for discrimination of ca125 overexpressed serum samples
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/1380d2a375a74a348ecd19bbfaf0087e
work_keys_str_mv	AT yishi developmentofarraybasedgoldnanoclustersfordiscriminationofca125overexpressedserumsamples AT xianhuigao developmentofarraybasedgoldnanoclustersfordiscriminationofca125overexpressedserumsamples AT weiwei developmentofarraybasedgoldnanoclustersfordiscriminationofca125overexpressedserumsamples AT youguochen developmentofarraybasedgoldnanoclustersfordiscriminationofca125overexpressedserumsamples
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Development of Array-Based Gold Nanoclusters for Discrimination of CA125 Overexpressed Serum Samples

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