Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review

Mitochondria are the primary organelles which can produce adenosine triphosphate (ATP). They play vital roles in maintaining normal functions. They also regulated apoptotic pathways of cancer cells. Given that, designing therapeutic agents that precisely target mitochondria is of great importance fo...

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Autores principales:	Zeng Zeng, Chao Fang, Ying Zhang, Cong-Xian Chen, Yi-Feng Zhang, Kun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mitochondria nanocarriers phototherapy chemotherapy combined immunotherapy Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/13855fc1deda43b9b89b7c9c65c915dc
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spelling	oai:doaj.org-article:13855fc1deda43b9b89b7c9c65c915dc2021-11-12T06:50:58ZMitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review2296-418510.3389/fbioe.2021.784602https://doaj.org/article/13855fc1deda43b9b89b7c9c65c915dc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.784602/fullhttps://doaj.org/toc/2296-4185Mitochondria are the primary organelles which can produce adenosine triphosphate (ATP). They play vital roles in maintaining normal functions. They also regulated apoptotic pathways of cancer cells. Given that, designing therapeutic agents that precisely target mitochondria is of great importance for cancer treatment. Nanocarriers can combine the mitochondria with other therapeutic modalities in cancer treatment, thus showing great potential to cancer therapy in the past few years. Herein, we summarized lipophilic cation- and peptide-based nanosystems for mitochondria targeting. This review described how mitochondria-targeted nanocarriers promoted highly efficient cancer treatment in photodynamic therapy (PDT), chemotherapy, combined immunotherapy, and sonodynamic therapy (SDT). We further discussed mitochondria-targeted nanocarriers’ major challenges and future prospects in clinical cancer treatment.Zeng ZengChao FangYing ZhangCong-Xian ChenYi-Feng ZhangKun ZhangFrontiers Media S.A.articlemitochondriananocarriersphototherapychemotherapycombined immunotherapyBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondria nanocarriers phototherapy chemotherapy combined immunotherapy Biotechnology TP248.13-248.65
spellingShingle	mitochondria nanocarriers phototherapy chemotherapy combined immunotherapy Biotechnology TP248.13-248.65 Zeng Zeng Chao Fang Ying Zhang Cong-Xian Chen Yi-Feng Zhang Kun Zhang Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review
description	Mitochondria are the primary organelles which can produce adenosine triphosphate (ATP). They play vital roles in maintaining normal functions. They also regulated apoptotic pathways of cancer cells. Given that, designing therapeutic agents that precisely target mitochondria is of great importance for cancer treatment. Nanocarriers can combine the mitochondria with other therapeutic modalities in cancer treatment, thus showing great potential to cancer therapy in the past few years. Herein, we summarized lipophilic cation- and peptide-based nanosystems for mitochondria targeting. This review described how mitochondria-targeted nanocarriers promoted highly efficient cancer treatment in photodynamic therapy (PDT), chemotherapy, combined immunotherapy, and sonodynamic therapy (SDT). We further discussed mitochondria-targeted nanocarriers’ major challenges and future prospects in clinical cancer treatment.
format	article
author	Zeng Zeng Chao Fang Ying Zhang Cong-Xian Chen Yi-Feng Zhang Kun Zhang
author_facet	Zeng Zeng Chao Fang Ying Zhang Cong-Xian Chen Yi-Feng Zhang Kun Zhang
author_sort	Zeng Zeng
title	Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review
title_short	Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review
title_full	Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review
title_fullStr	Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review
title_full_unstemmed	Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review
title_sort	mitochondria-targeted nanocarriers promote highly efficient cancer therapy: a review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/13855fc1deda43b9b89b7c9c65c915dc
work_keys_str_mv	AT zengzeng mitochondriatargetednanocarrierspromotehighlyefficientcancertherapyareview AT chaofang mitochondriatargetednanocarrierspromotehighlyefficientcancertherapyareview AT yingzhang mitochondriatargetednanocarrierspromotehighlyefficientcancertherapyareview AT congxianchen mitochondriatargetednanocarrierspromotehighlyefficientcancertherapyareview AT yifengzhang mitochondriatargetednanocarrierspromotehighlyefficientcancertherapyareview AT kunzhang mitochondriatargetednanocarrierspromotehighlyefficientcancertherapyareview
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Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review

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